Forward Progress

Who else wants to get noticed, move up and improve your football officiating? Forward Progress delivers proven methods from top college and pro football officials on how to get to the top of this avocation.

Ready to Run an Ultramarathon? When you consider marathons, do you think, "been there, done that"? Like so many others, do you believe that humans were born to run? Do you seek a new challenge that tests your mental and physical limits? If you answered yes to any of these questions, then it’s time to read "Relentless Forward Progress" and give ultramarathons a try! Veteran ultramarathoner and coach Bryon Powell shares insider know-ledge about training, racing, fueling, hydration, and much more. In this guide, you’ll find: --Daily training plans for races from 50k to 100 miles --A crash course in how to trail run --Advice from some of the world’s top ultrarunners --Proven strategies for race day success --Useful approaches for running uphill and downhill --What to look for in ultramarathon gear --Practical wisdom on speed work --Cross training ideas for running fitness and recovery --Tips on running barefoot --Inspiration to go farther than you’ve ever gone before

Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.

These Coaching Moments were created over the first several years in my own business as a leadership coach. I decided to write one every week and share them with leaders around the world, knowing that if my Coaching Moment resonated with just one person, I was touching them through coaching and helping them to become a better leader. This is the whole reason I took the leap into my own businessto help one leader at a time be the best leader that they can be. At certain times, a Coaching Moment has come from an actual conversation or top issue that one of my clients faced that week. At other times, Coaching Moments arose from situations that I observed throughout the course of my day. All of them are common challenges for leaders at all levels. Let these Coaching Moments serve as weekly practices for you. Browse the book alphabetically by heading, and find the leadership topic that hits home for you this week. Or pick a Coaching Moment at random. Try practicing one tip per week. Having this book alone takes you one step forward in your leadership. May these Coaching Moments raise your level of leadership and bring you success and joy, as these have for me to have written them. As you practice each one, commit to enjoy a great week.