From Ecology To Cancer Biology And Back Again

A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Every day, 1500 Americans die of cancer, and yet for most of us this deadly disease remains mysterious. Why is it so common? Why are there so many different causes? Why does treatment so often fail? What, ultimately, is cancer? In this fascinating new book, a leading cancer researcher offers general readers clear and convincing answers to these and many other questions. Mel Greaves places cancer in its evolutionary context, arguing that we can best answer the big questions about cancer by looking through a Darwinian lens. Drawing on both ancient and more modern evolutionary legacies, he shows how human development has changed the rules of evolutionary games, trapping us in a nature-nurture mismatch. Compelling examples, from the King of Naples intestinal tumor in the 15th century, through the epidemic of scrotal skin cancer in 18th-century chimney sweeps, to the current surge of cases of prostate cancer illustrate his thesis. He also shows why the old paradigms of infectious diseases or genetic disorders have proved fruitless when trying to explain this complex and elusive disease. And finally, he looks at the implications for research, prevention, and treatment of cancer that an evolutionary perspective provides. Drawing on the most recent research, this is the first book to put cancer in its evolutionary framework. At a time when Darwinian perspectives on everything from language acquisition to economics are providing new breakthroughs in understanding, medicine seems to have much to gain from the insights provided by evolutionary biology. Written in an exceptionally lucid and entertaining style, this book will be of broad interest to all those who wish to know more about this dread disease.

The words most commonly associated with the environmental movement—save, recycle, reuse, protect, regulate, restore—describe what we can do to help the environment, but few suggest how we might transform ourselves to better navigate the sudden turns of the late Anthropocene. Which words can help us to veer conceptually along with drastic environmental flux? Jeffrey Jerome Cohen and Lowell Duckert asked thirty brilliant thinkers to each propose one verb that stresses the forceful potential of inquiry, weather, biomes, apprehensions, and desires to swerve and sheer. Each term is accompanied by a concise essay contextualizing its meaning in times of resource depletion, environmental degradation, and global climate change. Some verbs are closely tied to natural processes: compost, saturate, seep, rain, shade, sediment, vegetate, environ. Many are vaguely unsettling: drown, unmoor, obsolesce, power down, haunt. Others are enigmatic or counterintuitive: curl, globalize, commodify, ape, whirl. And while several verbs pertain to human affect and action—love, represent, behold, wait, try, attune, play, remember, decorate, tend, hope—a primary goal of Veer Ecology is to decenter the human. Indeed, each of the essays speaks to a heightened sense of possibility, awakening our imaginations and inviting us to think the world anew from radically different perspectives. A groundbreaking guide for the twenty-first century, Veer Ecology foregrounds the risks and potentialities of living on—and with—an alarmingly dynamic planet. Contributors: Stacy Alaimo, U of Texas at Arlington; Joseph Campana, Rice U; Holly Dugan, George Washington U; Lara Farina, West Virginia U; Cheryll Glotfelty, U of Nevada, Reno; Anne F. Harris, DePauw U; Tim Ingold, U of Aberdeen; Serenella Iovino, U of Turin; Stephanie LeMenager, U of Oregon; Scott Maisano, U of Massachusetts, Boston; Tobias Menely, U of California, Davis; Steve Mentz, St. John’s U; J. Allan Mitchell, U of Victoria; Timothy Morton, Rice U; Vin Nardizzi, U of British Columbia; Laura Ogden, Dartmouth College; Serpil Opperman, Hacettepe U, Ankara; Daniel C. Remein, U of Massachusetts, Boston; Margaret Ronda, U of California, Davis; Nicholas Royle, U of Sussex; Catriona Sandilands, York U; Christopher Schaberg, Loyola U; Rebecca R. Scott, U of Missouri; Theresa Shewry, U of California, Santa Barbara; Mick Smith, Queen’s U; Jesse Oak Taylor, U of Washington; Brian Thill, Golden West College; Coll Thrush, U of British Columbia, Vancouver; Cord J. Whitaker, Wellesley College; Julian Yates, U of Delaware.