Frontiers In Transplantology

This book is addressed to researchers, practicing physicians, and surgeons in the field of organ transplantation, as well as the medical students, residents, and fellows. The topics covered include the religious concepts in organ transplantation, embryonic organ transplantation, tolerance, normothermic graft perfusion, pharmacogenetics of immunosuppressors, viral transmission in organ transplantation, pediatric and split-liver transplantation, portopulmonary hypertension, mechanical circulatory support, ex vivo lung perfusion, and ABO-incompatible kidney transplantation.

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In Defying the Gods, Scott McCartney takes the reader inside the world of organ transplants, focusing on four patients at the Baylor University Medical Center in Dallas. Baylor is home to one of the top three leading transplant teams in the country - a pair of "Top Gun" cutters who have stretched the boundaries of science to save lives. Defying the Gods shows not only what goes on inside the operating room, but also details the circumstances that brought the patients and the organs to the operating table - because for every triumphant successful transplant, there is the death of the person who donated the organ. McCartney follows the four patients on this difficult journey, from the weeks or even months of anguished waiting on the list of potential recipients, to the stressful recovery period when both doctors and patients watch tensely to see if the organ will be rejected by the patient's body - which in some cases means death. McCartney also profiles the transplant surgeons, who consider themselves on the cutting edge of medicine as they constantly push back the borders of death, and explains and critiques the transplant system: Who decides who gets one of the small number of available organs, and how is that decision made? Are doctors' and hospitals' hands tied by the laws regulating the collection and allocation of organs, or do they manipulate those laws? How important is it for patients to pass what doctors call the "wallet biopsy"? What can we do to assure an adequate supply of organs in the future? Defying the Gods is the definitive account of the history, science, and ethics that make transplants possible, covering the terrible choices transplantation presents for families, themoral dilemmas facing doctors, and the ongoing debate over how best to allocate the limited organs to those who need them. It is both suspenseful and moving, addressing important medical issues on a most human level.

The replacement of a diseased liver with a healthy liver is known as liver transplantation. Liver transplantation is used as a treatment option for acute liver failure and end-stage liver disease. Orthotopic transplantation is a common and effective technique used for liver transplantation. The transplantation surgery usually takes 4 to 18 hours. The common requirements for a liver donor include good health, a blood type which is compatible with the recipient, having an age of 20-60 years, and being of similar or larger size than the recipient. Liver transplantation involves a few complications, such as infection, bleeding, possibility of blood clots, painful incision and prolonged recovery. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of liver transplantation. It studies, analyzes and upholds the pillars of liver transplantation and its utmost significance in modern times. The extensive content of this book provides the readers with a thorough understanding of the subject.

- Donation refusal is high in all the regions of Argentina. - The deficient operative structure is a negative reality that allows inadequate donor maintenance and organ procurement. - In more developed regions, there are a high number of organs which are not utilized. This is true for heart, liver and lungs. Small waiting lists for these organs probably reflect an inadequate economic coverage for these organ transplant activities. - There is a long waiting list for cadaveric kidney transplants, which reflect poor procurement and transplant activity. - Lack of awareness by many physicians leads to the denouncing of brain deaths. In spite of these factors, we can say that there has been a significant growth in organ procuration and transplantation in 1993, after the regionalization of the INCUCAI. Conclusions Is there a shortage of organs in Argentina? There may be. But the situation in Argentina differs from that in Europe, as we have a pool of organs which are not utilized (donation refusal, operational deficits, lack of denouncing of brain deaths). Perhaps, in the future, when we are able to make good use of all the organs submitted for transplantation, we will be able to say objectively whether the number of organs is sufficient or not. Acknowledgements I would like to thank the University of Lyon and the Merieux Foundation, especially Professors Traeger, Touraine and Dr. Dupuy for the honour of being invited to talk about the issue of organ procurement.

Aimed at the trainee surgeon and experienced transplant surgeon, this compendium on split-liver grafting contains articles written by faculty members of the first International Course on Split-Liver Transplantation. It covers the main aspects of the field and is geared towards helping surgeons select the best surgical techniques as well as identifying the pitfalls. The text features detailed instructions on the various procedures as well as an overview of the area.

It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.

Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug designing Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system S Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.