Fundamental Statistical Methods For Analysis Of Alzheimer S And Other Neurodegenerative Diseases

Allowing more people to aid in analyzing data—while promoting constructive dialogues with statisticians—this book will hopefully play an important part in unlocking the secrets of these confounding diseases.

A statistics textbook that delivers essential data analysis techniques for Alzheimer's and other neurodegenerative diseases. Alzheimer's disease is a devastating condition that presents overwhelming challenges to patients and caregivers. In the face of this relentless and as-yet incurable disease, mastery of statistical analysis is paramount for anyone who must assess complex data that could improve treatment options. This unique book presents up-to-date statistical techniques commonly used in the analysis of data on Alzheimer's and other neurodegenerative diseases. With examples drawn from the real world that will make it accessible to disease researchers, practitioners, academics, and students alike, this volume • presents code for analyzing dementia data in statistical programs, including SAS, R, SPSS, and Stata • introduces statistical models for a range of data types, including continuous, categorical, and binary responses, as well as correlated data • draws on datasets from the National Alzheimer's Coordinating Center, a large relational database of standardized clinical and neuropathological research data • discusses advanced statistical methods, including hierarchical models, survival analysis, and multiple-membership • examines big data analytics and machine learning methods Easy to understand but sophisticated in its approach, Fundamental Statistical Methods for Analysis of Alzheimer's and Other Neurodegenerative Diseases will be a cornerstone for anyone looking for simplicity in understanding basic and advanced statistical data analysis topics. Allowing more people to aid in analyzing data—while promoting constructive dialogues with statisticians—this book will hopefully play an important part in unlocking the secrets of these confounding diseases.

As the essays in this volume show, conceptualizing dementia has always been a complex process. With contributions from noted professionals in psychiatry, neurology, molecular biology, sociology, history, ethics, and health policy, Concepts of Alzheimer Disease looks at the ways in which Alzheimer disease has been defined in various historical and cultural contexts. The book covers every major development in the field, from the first case described by Alois Alzheimer in 1907 through groundbreaking work on the genetics of the disease. Essays examine not only the prominent role that biomedical and clinical researchers have played in defining Alzheimer disease, but also the ways in which the perspectives of patients, their caregivers, and the broader public have shaped concepts.

This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.

Book 9 focuses on a new dementia type, LATE, mistaken as Alzheimer's disease until now.LATE stands for Limbic-predominant age-related TDP-43 encephalopathy, the protein buildup responsible for this dementia. This book is organic, like the series, meaning we never consider our books as finished. Science evolves, which is why our books go through continuous updates. Since LATE is a new dementia classification, we expect continuous further information to emerge. Watch Amazon alerts for potential digital updates. We provide free digital copies on all paperback purchases, so everybody receives free updates.

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.