Gastric Cancer An Issue Of Gastroenterology Clinics

Gastric cancer is the second most common cause of cancer mortality worldwide. Although the incidence of gastric cancer has declined over the past century in the United States, it remains one of the most common gastrointestinal neoplasms, particularly in immigrants and the socio-economically deprived. Recent years have seen major advances in our understanding of the pathogenesis of gastric cancer (especially regarding the importance of Helicobacter pylori and its associated inflammatory response) and the emergence of adjuvant oncologic therapies of proven benefit for advanced cases, in addition to surgery. As for gastric adenocarcinoma, elucidation of the underlying biology and molecular pathogenesis has led to much progress in the management of two other malignant gastric neoplasms, gastrointestinal stromal tumors and marginal zone B-cell (“MALT ) lymphomas. This monograph highlights these developments, presenting an updated overview of gastric cancer that will be of interest to all practicing gastroenterologists.

Gastric cancer refers to a type of cancer that grows from the lining of the stomach. There are different types of gastric cancer such as gastrointestinal stromal tumors, adenocarcinomas, carcinoid tumors and lymphoma. The major symptoms of gastric cancer include indigestion, and pain or discomfort in the stomach. The cancer may spread from the stomach and can affect other parts of the body including the lungs, lining of the abdomen, liver, lymph nodes and bones. The risk of developing gastric cancer can be influenced by factors such as nutrition, age and stomach disease. The diagnosis of this type of cancer is typically done through a biopsy performed during an endoscopy. Following this, medical imaging may also be performed to ascertain whether the disease has spread to other parts of the body. The treatment options of gastric cancer include surgery, radiation therapy and chemotherapy. This book strives to provide a fair idea about gastric cancer and to help develop a better understanding of the latest advances in its clinical management. For all readers who are interested in this medical condition, the case studies included herein will serve as an excellent guide to develop a comprehensive understanding.

In this issue of Diagnosis and Treatment of Gastrointestinal Cancers, guest editors Drs. Marta Davila and Raquel E. Davila bring their considerable expertise to the topic of Diagnosis and Treatment of Gastrointestinal Cancers. The early detection, diagnosis, and accurate staging of GI cancers, along with enhanced imaging techniques, new therapies, and a greater understanding of GI tumors at the molecular level, has revolutionized the approach to GI cancer patients in recent years. In this issue, distinguished authors recognized internationally as leading authorities in the field provide an exhaustive review of the latest topics in GI cancer. Contains 13 practice-oriented topics including management of Barrett’s esophagus and early esophageal adenocarcinoma; familial pancreatic cancer; colorectal cancer: screening and early detection; the microbiome in gastrointestinal cancers; and more. Provides in-depth clinical reviews on diagnosis and treatment of gastrointestinal cancers, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Provides in-depth, clinical reviews on Gastric Cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Provides in-depth, clinical reviews on Gastric Cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Gastrointestinal (GI) cancers account for nearly 150,000 deaths each year, in the United States alone. Encouragingly, environmental risk factors, premalignant conditions, and high-risk familial kindreds are well described for many GI cancers. In this comprehensive volume on GI Neoplasia, all luminal cancers will be discussed, along with pancreas cancer, gastrointestinal stromal tumors (GISTs), carcinoid tumors, and neuroendocrine tumors. Hepatobiliary cancers are not addressed, as these tumors could form the basis of a separate volume. Articles are organized to address several key topics for each cancer type, such as: public health burden, molecular pathways, risk and protective factors, early detection, clinical evaluation, management, and survivorship.

This issue of Surgical Oncology Clinics of North America, Guest Edited by Neal Wilkinson, MD, is devoted to the Management of Gastric Cancer. Articles in this issue will focus on Epidemiology; Genetics and Prophylactic Surgery; Endoscopic Diagnosis & Staging; Gastric Stromal Tumors (GIST); Management of Early Stage Gastric Cancer; Endoscopic Mucosal Resection (EMR); Tailored Lymphadenectomy; Laparoscopic Resection Gastric Cancer - Western Experience; Gastric Cancer - Eastern Experience; Update of Gastric Cancer Clinical Trials; Preoperative and Postoperative Chemotherapy for Gastric Cancer; and Phase I and II Clinical Trials.

This issue of Gastrointestinal Endoscopy Clinics provides a multidisciplinary approach to the evaluation and care of individuals with inherited gastrointestinal cancer conditions. With the many recent advances made in genomic medicine and the potential impact on medical management, the articles in this issue disseminate new knowledge on the identification and management of individuals and families with a genetic susceptibility to the development of gastrointestinal cancers, including the genetic basis and cancer risks associated with inherited cancer syndromes and integrated familial cancer risk assessment; genetic testing approaches; and incorporating genetic risk counseling into routine medical care. The goal is to improve detection of GI cancer syndromes, understand related cancer risks, and optimize strategies for the prevention and early detection of cancers to minimize morbidity and mortality. Integrating genetic assessment into gastrointestinal cancer care is highly relevant across the cancer care spectrum and gastroenterologists will come away with the most current evidence to enhance and improve their clinical practice. Provides in-depth, clinical reviews on Inherited GI Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 11 relevant, practice-oriented topics including Defining High-Risk Individuals for Pancreatic Cancer and the Role of Genetic Testing; Endoscopic Management and Surgical Consideration for FAP-Related Polyposis; Genetic Syndromes Associated with Gastric Cancer; Screening and Surgical Considerations in Hereditary Diffuse Gastric Cancer; and more.

In this issue of Diagnosis and Treatment of Gastrointestinal Cancers, guest editors Drs. Marta Davila and Raquel E. Davila bring their considerable expertise to the topic of Diagnosis and Treatment of Gastrointestinal Cancers. The early detection, diagnosis, and accurate staging of GI cancers, along with enhanced imaging techniques, new therapies, and a greater understanding of GI tumors at the molecular level, has revolutionized the approach to GI cancer patients in recent years. In this issue, distinguished authors recognized internationally as leading authorities in the field provide an exhaustive review of the latest topics in GI cancer. Contains 13 practice-oriented topics including management of Barrett's esophagus and early esophageal adenocarcinoma; familial pancreatic cancer; colorectal cancer: screening and early detection; the microbiome in gastrointestinal cancers; and more. Provides in-depth clinical reviews on diagnosis and treatment of gastrointestinal cancers, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.