Genetics Of Human Infertility
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Genetics of Human Infertility
Author | : P.H. Vogt |
Publsiher | : Karger Medical and Scientific Publishers |
Total Pages | : 178 |
Release | : 2017-09-12 |
Genre | : Medical |
ISBN | : 9783318060980 |
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Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.
The Genetics of Male Infertility
Author | : Douglas T. Carrell |
Publsiher | : Springer Science & Business Media |
Total Pages | : 337 |
Release | : 2007-11-08 |
Genre | : Medical |
ISBN | : 9781597451765 |
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In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
Towards Reproductive Certainty Fertility and Genetics Beyond 1999 The Plenary Proceedings of the 11th World Congress
Author | : R. Jansen,D. Mortimer |
Publsiher | : CRC Press |
Total Pages | : 556 |
Release | : 1999-04-15 |
Genre | : Medical |
ISBN | : 1850700842 |
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This is a forward-looking clinical reference of definitive authority on today's headline controversies surrounding in vitro fertilization (IVF) and reproductive genetics. Written by leading experts from medicine, education, psychology, ethics, counseling, and other disciplines studying fertility and genetics, the book contains nearly 70 chapters in seven sections. The introductory section deals with biology, business, morality and society in IVF and reproductive genetics; other sections focus on IVF outcomes, personal ethics and business, biology of the egg, sperm and embryo, implantation, IVF and society, and such 21st century topics as space travel and human reproduction, the disappearing male,and the future of motherhood. Includes bibliographic references and index.
The Genetic Basis of Male Infertility
Author | : Ken McElreavey |
Publsiher | : Springer Science & Business Media |
Total Pages | : 306 |
Release | : 2012-11-03 |
Genre | : Medical |
ISBN | : 9783540484615 |
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Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, Drosophila and mice provide a global overview of the field.
Reproductomics
Author | : José A. Horcajadas,Jaime Gosálvez |
Publsiher | : Academic Press |
Total Pages | : 425 |
Release | : 2018-07-23 |
Genre | : Medical |
ISBN | : 9780128126769 |
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Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts
Textbook of Human Reproductive Genetics
Author | : Karen Sermon,Stéphane Viville |
Publsiher | : Cambridge University Press |
Total Pages | : 217 |
Release | : 2014-04-10 |
Genre | : Medical |
ISBN | : 9781107683587 |
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This book brings together genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.
Genetics of Male Infertility
Author | : Mohamed Arafa,Haitham Elbardisi,Ahmad Majzoub,Ashok Agarwal |
Publsiher | : Springer Nature |
Total Pages | : 374 |
Release | : 2020-03-14 |
Genre | : Health & Fitness |
ISBN | : 9783030379728 |
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This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.
Genetic Damage in Human Spermatozoa
Author | : Elisabetta Baldi,Monica Muratori |
Publsiher | : Springer Science & Business Media |
Total Pages | : 195 |
Release | : 2013-08-16 |
Genre | : Medical |
ISBN | : 9781461477839 |
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There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.