Glutamine Repeats And Neurodegenerative Diseases
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Glutamine Repeats and Neurodegenerative Diseases
Author | : Peter S. Harper,Max F. Perutz |
Publsiher | : Oxford University Press, USA |
Total Pages | : 352 |
Release | : 2001 |
Genre | : Medical |
ISBN | : UOM:39015051307505 |
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This book focuses on the discovery of a common genetic basis for a group of inherited neurological disorders, including Huntington's Disease, spino-bulbar atrophy and a series of hereditary ataxias. This shared molecular background and other similarities have led to the development of theoretical models for the pathogenesis of these diseases. It is now also clear that the mechanisms involved are likely to be of more general relevance, outside of this particular group of disorders, with implications for other neurodegenerative processes such as those involved in Alzheimer's, Parkinson's and Prion diseases. The book is an edited and updated compilation evolving from a Royal Society discussion meeting.
Glutamine Repeats and Neurodegenerative Diseases
Author | : Royal Society (Great Britain). Discussion Meeting |
Publsiher | : Unknown |
Total Pages | : 164 |
Release | : 1999 |
Genre | : Amino acid sequence |
ISBN | : OCLC:42365812 |
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Glutamine Repeats and Neurodegenerative Diseases
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 164 |
Release | : 1999 |
Genre | : Electronic Book |
ISBN | : OCLC:924259229 |
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Polyglutamine Disorders
Author | : Clévio Nóbrega,Luís Pereira de Almeida |
Publsiher | : Springer |
Total Pages | : 469 |
Release | : 2018-02-09 |
Genre | : Medical |
ISBN | : 9783319717791 |
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This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
Neuropathology of Neurodegenerative Diseases Book and Online
Author | : Gabor G. Kovacs |
Publsiher | : Cambridge University Press |
Total Pages | : 319 |
Release | : 2014-12-04 |
Genre | : Medical |
ISBN | : 9781107442429 |
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This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.
Molecular Mechanisms of Neurodegenerative Diseases
Author | : Marie-Francoise Chesselet |
Publsiher | : Springer Science & Business Media |
Total Pages | : 416 |
Release | : 2000-10-19 |
Genre | : Medical |
ISBN | : 9781592590063 |
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With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
The Neuropathology of Huntington s Disease Classical Findings Recent Developments and Correlation to Functional Neuroanatomy
Author | : Udo Rüb,Jean Paul G. Vonsattel,Helmut Heinsen,Horst-Werner Korf |
Publsiher | : Springer |
Total Pages | : 146 |
Release | : 2015-09-29 |
Genre | : Medical |
ISBN | : 9783319192857 |
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This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
Genetics of Movement Disorders
Author | : Stefan M. Pulst |
Publsiher | : Elsevier |
Total Pages | : 585 |
Release | : 2002-10-25 |
Genre | : Medical |
ISBN | : 9780080532417 |
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Hereditary or genetic diseases featuring involuntary movements constitute a major aspect of the practice of neurology, functional neurosurgery, genetics, and many areas of basic and applied neuroscience research. Describing the current knowledge on these disorders, Genetics of Movement Disorders brings together information essential for clinicians, geneticists, and neuroscientists in one source. Utilizing a convenient and accessible format, the book is designed to allow easy identification of relevant information, with the overall organization of topics following established phenotypic classifications of movement disorders such as Parkinsonian syndromes, chorea, ataxia, and major categories of diseases grouped by gene locus. This book broadly appeals to neurologists, neuroscientists, geneticists, as well as cell and molecular biologists and hematologists. Consistently formatted to present a clinical description of the disorder, followed by an in-depth analysis of the mutation and function of the mutated gene including cellular and animal models Emphasizes the use of DNA tests for each respective disorder Provides up-to-date, easily accessible information for clinicians, geneticists, and neuroscientists