Handbook Of Imaging The Alzheimer Brain

Alzheimers disease is a common problem that is becoming progressively more prevalent and burdensome to the world. Through better recognition of this disease and more precise diagnosis, led by brain imaging in the appropriate clinical context, it is our

Alzheimers disease is a common problem that is becoming progressively more prevalent and burdensome to the world. Through better recognition of this disease and more precise diagnosis, led by brain imaging in the appropriate clinical context, it is our

The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field Summarizes the most recent developments in the fields of Alzheimer's disease and dementia Brings together articles from a prominent and international group of contributors Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences

The Oxford Handbook of Functional Brain Imaging in Neuropsychology and Cognitive Neurosciences describes in a readily accessible manner the several functional neuroimaging methods and critically appraises their applications that today account for a large part of the contemporary cognitive neuroscience and neuropsychology literature. The complexity and the novelty of these methods often cloud appreciation of the methods' contributions and future promise. The Handbook begins with an overview of the basic concepts of functional brain imaging common to all methods, and proceeds with a description of each of them, namely magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), diffusion tensor imaging (DTI), and transcranial magnetic stimulation (TMS). Its second part covers the various research applications of functional neuroimaging on issues like the function of the default mode network; the possibility and the utility of imaging of consciousness; the search for mnemonic traces of concepts; human will and decision-making; motor cognition; language; the mechanisms of affective states and pain; the presurgical mapping of the brain; and others. As such, the volume reviews the methods and their contributions to current research and comments on the degree to which they have enhanced our understanding of the relation between neurophysiological activity and sensory, motor, and cognitive functions. Moreover, it carefully considers realistic contributions of functional neuroimaging to future endeavors in cognitive neuroscience, medicine, and neuropsychology.

This book explores various state-of-the-art aspects behind the statistical analysis of neuroimaging data. It examines the development of novel statistical approaches to model brain data. Designed for researchers in statistics, biostatistics, computer science, cognitive science, computer engineering, biomedical engineering, applied mathematics, physics, and radiology, the book can also be used as a textbook for graduate-level courses in statistics and biostatistics or as a self-study reference for Ph.D. students in statistics, biostatistics, psychology, neuroscience, and computer science.

Dementia is a massive and increasing global problem, with the current prevalence anticipated to double every 20 years as people live longer. Neuroimaging in dementia is recommended by most clinical guidelines and its role has traditionally been to exclude a mass lesion, rather than to support a specific diagnosis. All radiologists will be aware of a steady rise in the number of requests for brain imaging in old people, but what can imaging reliably tell us and what kind of imaging should we use? In affluent societies we now have a range of structural and molecular brain imaging techniques at our disposal, with specific ligands and sophisticated image analysis techniques now available for clinical use. However, we have difficulty justifying which patients to scan, using which modality and when. We know that Alzheimer's disease is the most common neuropathology contributing to a diagnosis of Alzheimer's disease but we also know from large post-mortem studies that most brain pathology in those who have died with a diagnosis of dementia is mixed. Thus understanding different diseases that can cause dementia, how these co-exist or interact and appreciating that not all dementia is Alzheimer's disease is important. Equally important is awareness of individual differences in response to a neuropathological burden and what factors provide resilience against dementia that might be maximized to reduce or postpone its impact. This issue draws together contributions from experts in their fields to provide clarity to the topic in a comprehensive collection of articles.

This up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with cognitive decline. It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible. After an introductory chapter on the clinical background, the available "toolbox" of structural and functional neuroimaging techniques is reviewed in detail, including CT, MRI and advanced MR techniques, SPECT and PET, and image analysis methods. The imaging findings in normal ageing are then discussed, followed by a series of chapters that carefully present and analyze the key findings in patients with dementias. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book will prove an invaluable resource.

Neuroimaging, Part One, a text from The Handbook of Clinical Neurology illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This first volume specifically covers a description of imaging techniques used in the adult brain, aiming to bring a comprehensive view of the field of neuroimaging to a varying audience. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, and the entire field is moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to this new horizon in the study of neurological disorders. Provides a relevant description of the technologies used in neuroimaging, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and several others Ideal resource for anyone studying the nervous system, from beginners to specialists interested in recent advances in neuroimaging of the adult brain Discusses the application of imaging techniques to the study of brain and spinal cord disease and its use in various syndromes Contains vibrant, colorful images to illustrate key points