Handbook Of Transcription Factor Nf Kappab
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Handbook of Transcription Factor NF kappaB
Author | : Sankar Ghosh |
Publsiher | : CRC Press |
Total Pages | : 232 |
Release | : 2006-10-20 |
Genre | : Medical |
ISBN | : 9781420004274 |
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Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is proving to be the most protean of all transcription factors. It has been shown to function in most cell types as a key regulator of a number of inducible genes. Research on the responsibilities and resulting pathologies of NF-kB has been prolific, but until now there has been no consolidated, multidisciplinary reference. Providing contributions from leading authorities involved with seminal discoveries on the subject, Handbook of Transcription Factor NF-kappaB is an entry point to understanding the broad role of this widely studied factor. Beginning with a summary, the authors introduce the uninitiated reader to the complexities of the NF-kB system. They explain how a multitude of extracellular and intercellular signals integrated at the level of this transcription factor have led to fundamental insights about many aspects of gene regulation and signal transduction. The chapters delve into specific research aspects concerning the function and regulation of NF-kB in a number of biological systems. They discuss inflammation, innate and adaptive immunity, liver integrity, and nervous system development, as well as the formation of hair, skin, teeth, and many other aspects of the developing vertebrate body. The pathological effects of excess NF-kB activity are addressed in chapters on diseases related to chronic inflammation, such as heart disease, muscular dystrophy, cancer, and tumor proliferation, as well as diseases caused by inherent deficiencies in NF-kB. The text culminates in a discussion of current efforts to develop therapies aimed at inhibiting the aberrant activity of NF-kB in different diseases.
NF kB Rel Transcription Factor Family
Author | : Hsiou-Chi Liou |
Publsiher | : Springer Science & Business Media |
Total Pages | : 202 |
Release | : 2007-02-26 |
Genre | : Science |
ISBN | : 9780387335735 |
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Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.
A Handbook of Transcription Factors
Author | : Timothy R. Hughes |
Publsiher | : Springer Science & Business Media |
Total Pages | : 306 |
Release | : 2011-05-10 |
Genre | : Medical |
ISBN | : 9789048190690 |
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Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
NF B Transcription Factors
Author | : Guido Franzoso,Francesca Zazzeroni |
Publsiher | : Humana |
Total Pages | : 359 |
Release | : 2021-07-09 |
Genre | : Medical |
ISBN | : 1071616684 |
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This detailed book serves as a systematic examination of the analytical methods to study the transcription factor NF-κB in physiology and disease. It provides an up-to-date guidebook to navigate both conventional and highly specialized methods to detect and analyze the different signaling pathways of NF-κB activation and contextualize them within organismal physiology and disease pathogenesis, using genetic and biochemical techniques and some of the most advanced computational and systems biology methods. Additionally, the volume includes several examples of approaches utilized by leading experts in the NF-κB field to analyze and modulate NF-κB signaling in specific physiological and disease contexts, along with some of the most promising approaches to pharmacologically target the NF-κB pathway in human disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, NF-κB Transcription Factors: Methods and Protocols is an up-to-date guide intended for both basic and translational scientists who are working in the dynamic NF-κB field.
Inhibition of NF Kappa B I Kappa B Transcription Factor Activation by Antioxidants
Author | : Raymond Min Hang Lee |
Publsiher | : Unknown |
Total Pages | : 0 |
Release | : 1997 |
Genre | : Electronic Book |
ISBN | : OCLC:428016367 |
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Transcription Factors
Author | : Manfred Gossen,Jörg Kaufmann,Steven J. Triezenberg |
Publsiher | : Springer Science & Business Media |
Total Pages | : 573 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 9783642189326 |
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With contributions by numerous experts
Structure of the Human Transcription Factor NF k63B NF kappaB P52 Homodimer DNA Complex
Author | : Patrick Cramer |
Publsiher | : Unknown |
Total Pages | : 226 |
Release | : 1997 |
Genre | : Electronic Book |
ISBN | : OCLC:312911307 |
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A Handbook of Transcription Factors
Author | : Timothy R. Hughes |
Publsiher | : Springer |
Total Pages | : 306 |
Release | : 2011-05-26 |
Genre | : Medical |
ISBN | : 9048190703 |
Download A Handbook of Transcription Factors Book in PDF, Epub and Kindle
Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.