Hyperbaric Oxygen Treatment In Research And Clinical Practice

Hyperbaric oxygen treatment (HBO2) is a widely accepted adjuvant therapy in various health conditions that exhibit impaired tissue blood flow. At high pressures, the delivery of the dissolved oxygen in plasma is enhanced, which contributes to better tissue oxygenation, cellular metabolism and ultimately, healing. However, this is not the only beneficial outcome of HBO2 treatment since oxygen is a highly reactive molecule and can induce upregulation of many enzymatic systems in the cell at the cellular, genetic and molecular level. Particularly, vascular/endothelial function is affected by the HBO2. Our understanding of these mechanisms is still emerging. There have been many controversies related to the HBO2 protocols and indications. As well as exhibiting beneficiary effects on the tissue perfusion, it is known that HBO2 demonstrates high toxicity at higher pressures, due to increased oxidative stress and barotrauma. On the other hand, there is a lack of translation of the knowledge on the mechanisms of action of HBO2 obtained from the experimental research to the clinical practice. Thus, this book presents the reader with an overview of the current knowledge on the mechanisms of HBO2 effects in various experimental models and clinical treatment protocols, in an attempt to provide a better understanding of how and when HBO2 should be used as an effective therapy without unwanted side effects.

Hyperbaric oxygen treatment (HBO2) is a widely accepted adjuvant therapy in various health conditions that exhibit impaired tissue blood flow. At high pressures, the delivery of the dissolved oxygen in plasma is enhanced, which contributes to better tissue oxygenation, cellular metabolism and ultimately, healing. However, this is not the only beneficial outcome of HBO2 treatment since oxygen is a highly reactive molecule and can induce upregulation of many enzymatic systems in the cell at the cellular, genetic and molecular level. Particularly, vascular/endothelial function is affected by the HBO2. Our understanding of these mechanisms is still emerging. There have been many controversies related to the HBO2 protocols and indications. As well as exhibiting beneficiary effects on the tissue perfusion, it is known that HBO2 demonstrates high toxicity at higher pressures, due to increased oxidative stress and barotrauma. On the other hand, there is a lack of translation of the knowledge on the mechanisms of action of HBO2 obtained from the experimental research to the clinical practice. Thus, this book presents the reader with an overview of the current knowledge on the mechanisms of HBO2 effects in various experimental models and clinical treatment protocols, in an attempt to provide a better understanding of how and when HBO2 should be used as an effective therapy without unwanted side effects.

The decade since the first Handbook on Hyperbaric Medicine has seen major advances: studies have clarified the actions of hyperbaric oxygenation; clinical practice is becoming more scientific; various organisational and operational guidelines are now widely accepted. This new Handbook arises from the EU Co-operation in Science and Technology (COST) programme for hyperbaric medicine, COST B14, in combination with the results of a number of recent experimental and clinical studies.

A textbook may sometimes gain the unusual trait of longevity beyond all other books - it can be revised and remain a primary source of information for generations of students. Hyperbaric Medicine Practice seems destined to become such a book. This 4th edition, edited by Harry T. Whelan, pays tribute to its original author, Dr. Kindwall, who died in 2012. It also adds new information of interest to all in the field of diving and clinical hyperbaric medicine. Most chapters have been written or revised by new authors, but many have returned to update their chapters. New chapters include indications for hyperbaric oxygen treatment subjects recently approved for treatment such as idiopathic sudden sensorineural hearing loss and central retinal vein occlusion. There are also chapters on submarine rescue and problems that pertain to technical and rebreather diving. This book will be an important addition to the library of physicians in clinical hyperbaric medicine and those involved with divers—recreational, commercial, and military—as well as other professionals who care for them. - comments by Henry J.C. Schwartz, MD, FACP New Information and Updates in the Fourth Edition Indications for the Use of HBO2 - Completely re-written chapters on basis for HBO2 therapy of Radiation Necrosis and Burns - New clinical trial data for traumatic brain injuries - Tabulation of almost all published cases of hyperbaric oxygen used for refractory osteomyelitis and the new CPT codes needed for reimbursements - Updates on the multiplace hyperbaric chamber with monitoring and provisions for critical care and carbon monoxide emergency - A new complete description of the multiplace hyperbaric chamber as a medical device - Improved illustrations and better clarification for the use of hyperbaric oxygen for crush injuries - Totally new chapter on the role of hyperbaric oxygen for fracture management - Complications and Contraindications for the Use of HBO2 - Completely re-written chapter on the contraindications and relative risks, and the management recommendations - Completely re-written chapter on complications and the management recommendations - Updated details on use of medications and indications for myringotomy The Science of HBO2 - Additional basic science and clinical data regarding HBO2 management of infectious diseases - Completely re-written chapter on basis for HBO2 therapy of Infectious Diseases - Updates on mechanism of action of HBO2 and preconditioning - Added human and animal literature section utilizing hyperbaric oxygen for brown recluse spider bite - Re-written evidence-based recommendations for use of hyperbaric oxygen for brown recluse spider bite - New innovative research developed in Brazil when the first lines of hyperbaric medicine therapy history in South America were written. - Introduces challenging questions to readers including: Should we try HBO2 for Hansen’s disease in present day? Is there any better way to increase oxygen toxicity against Mycobacterium leprae than methylene blue? - All new hyperbaric oxygen mechanism chapter complimented by exceptionally well-illustrated figures - New approach to appreciating the mechanisms of hyperbaric oxygen with primary effects that occur immediately and secondary effects that are long standing and generally require repetitive treatments - In-depth discussion about the physiological, cellular and molecular response to exogenous ketone supplementation and ketogenic diet - New section on pharmacokinetic disposition of drugs in HBO2 New section on antibiotic interactions Updated literature on pharmacodynamics interactions Fully updated discussion on the use of hyperbaric oxygen therapy in pediatrics including risks and benefits, practical considerations, indications and controversies and oxygen administration schedules Discussion of latest information on pediatric disease indications for hyperbaric oxygen therapy and current controversies Updated recommendations for pediatric psychological preparation and sedation

HOPE FOR MANY “HOPELESS” DISEASES, FROM ONE OF THE FOREMOST RESEARCHERS IN THE FIELD When Randy McCloy, Jr., the sole survivor of the Sago Mine disaster, finally walked out of the hospital to rejoin his family, it was in part due to the miracle of hyperbaric oxygen therapy. Hyperbaric oxygen therapy (HBOT) is based on an almost laughably simple idea: Oxygen can be used therapeutically for a wide range of conditions where tissues have been damaged by oxygen deprivation. Restore that oxygen, goes the logical thinking, and you can restore much of the lost function. It seems too good to be true, but Dr. Paul G. Harch’s research and clinical practice has shown that this noninvasive and painless treatment can help the tens of millions of Americans who suffer from a brain injury or disease, such as: · Stroke · Autism and other learning disabilities · Cerebral palsy and other birth injuries · Alzheimer’s, Parkinson’s, multiple sclerosis, and other degenerative neurological diseases · Emergency situations requiring resuscitation, such as cardiac arrest, carbon monoxide poisoning, or near drowning It can also improve conditions in which inflammation is the culprit, such as arthritis and asthma; promote healing in infections, burns, and skin grafts, such as diabetic foot wounds; and slow the aging process. For the millions of Americans suffering from these seemingly “hopeless” diseases, here finally is the handbook of hope. Inspiring and informative, The Oxygen Revolution is the definitive guide to the miracle of hyperbaric oxygen therapy, from a pioneer in the field.

Written by internationally recognized leaders in hyperbaric oxygen therapy (HBOT) research and practice, this exciting new book provides evidence-based, practical, useful information for anyone involved in HBOT. It outlines the physiologic principles that constitute the basis for understanding the clinical implications for treatment and describes recent advances and current research, along with new approaches to therapy. This book is an essential tool for anyone who cares for patients with difficult-to-heal wounds, wounds from radiation therapy, carbon monoxide poisoning, and more. Provides comprehensive coverage of pathophysiology and clinically relevant information so you can master the specialty. Covers the relevance of HBOT in caring for diverse populations including critical care patients, infants and pediatric patients, and divers. Features a section on the technical aspects of HBOT to provide insight into the technology and physics regarding HBO chambers. Presents evidence to support the effectiveness of HBOT as well as the possible side effects. Describes situations where HBOT would be effective through indication-specific chapters on chronic wounds, radiation and crush injuries, decompression sickness, and more.

The field of hyperbaric medicine, along with hyperbaric centers throughout the United States and abroad, continues to grow. This growth has been exponential, touting an increase from 350 centers in 1993 to well over 2,500 programs today. With this progression exists a need to establish a resource guideline for developing complete and comprehensive policies and procedures for clinical hyperbaric units. Hyperbaric policy and procedures provide the guiding principles and foundation for safety, quality, transparency, and cost-effective hyperbaric medical and nursing practice. Every hyperbaric facility needs to follow its specific policies and procedures. Policy and Procedural Guidelines for Hyperbaric Facilities provides needed resource and reference guidelines for new and established hyperbaric facilties. It will serve as a reference for the development of new hyperbaric policies as well as customize and enhance current policies and procedures already in place. Policy and Procedural Guidelines for Hyperbaric Facilities addresses issues of safety and practice for both the multiplace and monoplace environments. It utilizes regulatory guidelines and standards of practice as its foundation. Topics covered in this work include, but are not limited to, governance, administration, emergency procedures, patient care, hyperbaric chamber maintenance, treatment protocols and quality improvement. The appendices include sample forms for both Class A multiplace and Class B monoplace chambers. They are intended to serve as templates for development of hyperbaric unit-specific forms. Also included are acronyms, references, and an index, all specific to hyperbaric medicine. The guidelines provided in this document will benefit the diverse group of physicians, nurses, tecnicians, and allied health-care peronnel in the hyperbaric field as they customize their unit-specific policies and procedures. The contributing authors are comprised of established experts in the field of undersea and hyperbaric medicine. They are a diverse group of physicians, nurses, and technologists who devoted an extensive amount of time and energy into producing this resource document of the highest quality. Specific acknowledgements can be found in the List of Contributors section of the book. Endorsement from Baromedical Nurses Association (BNA) The Baromedical Nurses Association (established 1985) provides a forum for hyperbaric nursing that encompasses quality, safety, teamwork, mentoring, research, education, and nursing guidelines of standards of care for the patient receiving hyperbaric oxygen therapy. The Baromedical Nurses Association endorses the Policy and Procedural Guidelines for Hyperbaric Facilities as guidelines to enable hyperbaric facilities to develop and/or endorse their unit-specific policies.