Infections And The Rheumatic Diseases

This book provides a comprehensive and up-to-date review of the basic and clinical aspects of infections and infectious processes that trigger or aggravate a variety of autoimmune and inflammatory musculoskeletal disorders. It delivers a timely update on the interactions between infection and rheumatic diseases in order to provide clinicians with the tools they need for proper diagnosis and treatment. The book is divided into five main sections. The first examines the basic aspects of bacterial infections with a discussion of molecular biology, the microbiome, various types of bacteria that cause infection, and recent advances in biologic therapy. The next section focuses on different forms of viral arthritis including hepatitis arthritis, arthritis associated with alpha viruses, and parvovirus-related arthritis. Subsequent chapters then discuss arthritis caused by mycobacteria, fungi, spirochete, and other miscellaneous arthritides. Following this are various analyzations on reactive arthritis and infection-related rheumatic diseases such as Whipple’s Disease, SAPHO Syndrome, rheumatic fever, and HIV-associated rheumatic manifestations. Finally, the book closes with three chapters on external impacts on infectious diseases such as climate change, vaccinations and systemic lupus erythematosus. Infections and the Rheumatic Diseases is an essential resource for physicians and related professionals, residents, fellows, graduate students, and nurses in rheumatology, clinical immunology, and internal medicine.

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today’s available information and guidance into a single, convenient resource.

Autoimmune and rheumatic diseases are two close allies. Differential diagnosis of both disease groups can be cumbersome since the clinical signs of rheumatic and infectious disorders are very similar. This book addresses the fact that infectious disease can either mimic or complicate rheumatic diseases. In the first part, cases of with standard rheumatic symptoms patients triggered by infections and differential diagnosis are presented. The second part is dedicated to the complications of rheumatic disease infections. Standard patient cases are presented as well as risk factors, clinical features and microbial spectra. Further chapters inform about the impact of anti-rheumatic and immunomodulatory drug therapies (incl. biological agents) on infectious risk, the specific aspects of vaccination during immunosuppressive therapy and issues about the infectious risk and chemoprophylaxis during orthopedic surgery. This book provides clinicians a detailed insight between rheumatic and infectious disease.

This issue of the Rheumatic Disease Clinics of North America brings the rheumatologist up to date on the latest breakthroughs in the assessment and treatment of infections in rheumatic diseases. Lumiary ACR Master, Luis Espinoza Guest Edited this issue, which covers topics including molecular biology of infectious agents ion chronic arthritis; gonococcal and non-gonococcal arthritis; soft tissues (bursitis, tendonitis) infections; clinical and medical management of reactive arthritis; septic complications in pediatric and adult patients with systemic lupus erythematosus; Lyme arthritis; the role of parvovirus B19 in chronic arthritis; hepatitis C-associated rheumatic disorders; hepatitis B-related autoimmune manifestations; HIV-associated rheumatic disorders; assessment of latent tuberculosis in rheumatic disorders; and infectious complications of biologic agents.

This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.

The relationship between infection and arthritis has occupied the attention of everybody throughout the history of investigative rheu matology, no less today than formerlyl. The present issue is a com pilation of essays reflecting some of the facets of this particular diamond and I am especially grateful to authors and publishers alike in the unusual and tragic circumstances which attended its preparation. We were all stunned and saddened by the untimely death of Pro fessor John Calabro which deprived us of a good friend and wise counsellor as well as a much esteemed professional colleague. Prof. Calabro's contribution to medicine was considerable, spanning highly individual, exemplary and caring clinical management, enthusiastic charismatic teaching at all levels and major contributions to research particularly in the field of juvenile arthritis. As with Robert Burns, whose works John knew, "when will we see his like again?". A personal sadness is that I was looking forward to welcoming John and his wife to "Geordieland". There is a strong tradition of the highest level of competitive ballroom dancing here and John was looking forward to visiting us and demonstrating the considerable skills which he and his wife displayed in this arena. To his wife and family we all extend our heartfelt condolences. W. CARSON DICK 1. Atkin, S., Walker, D., Mander, M., Malcolm, A. and Dick, W. Carson. (1988). Observation on the causes of rheumatoid arthritis. Br. J. Rheumatol., 27 (Suppl.