Infections In Cancer Chemotherapy

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

While advances in both the treatment of cancer and the management of its complications have led to significant improvement in patient survival, infections remain a significant cause of morbidity and mortality in patients with neo plastic disease. In this patient population, infection risk results from a complex interplay between the host’s underlying immunodeficiencies, local tumor effects and treatment-induced immunosuppression. New chemotherapeutic approaches and antimicrobial prophylaxis and treatment practices continue to shape the spectrum of infections in these patients. Clinicians who treat infections in cancer patients are continually challenged by the emergence of new pathogens and by the increasing antimicrobial resistance of established ones. The aim of this book is to emphasize unique aspects of management of infectious diseases in the cancer patient. With the increasing complexity of this patient population, optimal management requires a multidisciplinary approach and this fact is fully reflected in the contributions, all from recognized authorities in the field. Ultimately, it is hoped that this volume will assist specialists in infectious diseases and haematology/oncology in the diagnosis, management and prevention of infection and optimization of the overall care of patients with malignancies.

Infections in Cancer Chemotherapy is a collection of paper that details the advancement in the understanding of infections in chemotherapy. The coverage of the text includes aggressive cancer treatment and its role in predisposing to infection; diagnosis of infection in patients with cancer; and non-bacterial infections associated with neoplastic disease. The selection also tackles the protocol for an international prospective trial of initial therapy regimens in neutropenic patients with malignant disease; and the use of gnotobiotics in hematology in improving acute leukemia treatment. The book will be of great interest to oncologists and hematologists.

Infection in the cancer patient is extremely common, either precipitated by the cancer itself or by the cancer therapies. Virtually all cancer patients develop an infection during their illness, often life-threatening and requiring urgent treatment. This book decribes the presentation and management of all infections met by the clinician.

Despite the major developments in the therapeutic armamentarium for the treatment of infection, the morbidity and mortality of this complication remains very high in patients with compromised defences. Cancer and its treatment represents a major predisposing condition to a variety of infections. These adverse events are still with us, in spite of much progress in the therapy of infectious disease, since cancer therapy is becoming more aggressive, yet further lowering the host's capacity to cope with infections. Moreover, the pathogens adapt effectively to drugs, and at a pace that might outrun industry's capability to produce new agents. Finally, new pathogens are appearing as a consequence of both selection and severe immunosuppression. Infection is so common among cancer patients that its diagnosis and management represent a daily challenge to all oncologists, who must continually strive to keep abreast of developments in the area. The present comprehensive review of the most crucial and challenging aspects of the infectious complications in cancer patients will help them to do just that.

Infections in Cancer Chemotherapy is a collection of paper that details the advancement in the understanding of infections in chemotherapy. The coverage of the text includes aggressive cancer treatment and its role in predisposing to infection; diagnosis of infection in patients with cancer; and non-bacterial infections associated with neoplastic disease. The selection also tackles the protocol for an international prospective trial of initial therapy regimens in neutropenic patients with malignant disease; and the use of gnotobiotics in hematology in improving acute leukemia treatment. The bo ...