Innate Immunity And The Eye

The innate immune system comprises the cells and mechanisms that are the first line of defence against infection by other organisms. This book provides a comprehensive synopsis of eye diseases, their immunological mechanisms and the role of the immune cells and mediators. Beginning with an introduction to the role of the innate immune system, the following chapters discuss the different types of immune cells in the eye and their role in the etiopathogenesis of various diseases including glaucoma and age-related macular degeneration. Edited by Manfred Zierhut, recognised expert from the University of Tuebingen Germany, this book is presented in an easy to read format, enabling practitioners to understand even the most sophisticated eye disorders from an immunological perspective. Key points Comprehensive synopsis of the role of the innate immune system in eye diseases Covers different types of immune cells Edited by internationally recognised specialist in Germany

This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support structures and organs. Rather than taking an immunological focus that is strictly suitable for clinicians, the volume offers a considerable basic science background and addresses a broad range of topics - the immune system of the eye, its various disorders, mechanisms of inflammation of the eye and visual system, treatment, wound healing mechanisms, stem cells, and more. The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of ocular immunology Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers The best researchers in the field provide their conclusions in the context of the latest experimental results

In memory of J. Wayne Streilein, the pioneer in ocular immunology The second edition of Immune Response and the Eye' highlights recent insights into the dangerous compromise' between the immune system and the eye, which protects the eye against pathogens while limiting inflammation and immune-mediated injury to ocular tissues with little or no regenerative potential. It discusses the broad spectrum of physiological, immunological, anatomical, and biochemical adaptations that conspire to closely regulate the tone and tenor of immune responses in the eye. This volume further describes immune-mediated diseases that occur when the compromise between the immune system and the eye is breached. This breakdown in immune privilege threatens the vision of millions each year. Finally, recent advances in ocular immunology are presented, which offer potential therapeutic applications in corneal and retinal transplantation and in the management of blinding autoimmune diseases of the eye. Eye researchers, ophthalmologists and immunologists will appreciate the state-of-the-art and authoritative information presented in Immune Response and the Eye'

In this book, the physiologic bases of ocular immune privilege and the distinctive systemic immune responses elicited by eye derived antigens are described. Several chapters discuss the pathogeneses of these disorders which arise from infections, autoimmunity, and neoplasms. Finally, chapters devoted to corneal and retinal transplantation describe attempts to exploit ocular immune privilege to promote graft survival and thereby cure blindness. Ophthalmologists, both clinicians and physician scientists, general and tumor immunologists, transplantation biologists and anyone seeking to understand the immunopathogenic diseases that threaten vision will appreciate the information presented in this book.

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Comprehensive and readable, Whitcup and Nussenblatt's Uveitis, 5th Edition, covers every aspect of this complex subspecialty in a single convenient volume. This clinically relevant guide covers the medical, pharmacological, and surgical treatment of uveitis in a visually rich, full-color format, offering a complete overview for today’s clinicians. New and updated case studies, key points boxes, and more than 400 images and graphics highlight major clinical points and provide insight into real situations that you can apply in practice. Features multiple chapters on diagnostic approach to help you meet the challenge of making accurate diagnoses. Reflects advancements and new developments on all aspects of uveitis including new medical and surgical treatments. Covers key topics such as the use of PCR in diagnostic testing, cataract surgery in patients with uveitis, the use of OCT in diagnosis and treatment, new infectious causes of uveitis (including Zika and Ebola), and novel treatments for inflammatory eye disease. Includes new clinical photographs, illustrations, and OCT images throughout. Reviews new randomized clinical trials of new uveitis therapy, as well as the approach to patients with HIV and HIV-associated ocular diseases including CMV retinitis and immune recovery uveitis. Provides expanded information on masquerade syndromes with important tips on diagnosis and management of intraocular lymphoma.

This book addresses approaches to the treatment of retinal diseases, targeting common processes and components.

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.