Intellectual Disabilities In Down Syndrome From Birth And Throughout Life Assessment And Treatment

Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer's disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90's and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer's disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer's disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90's and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer's disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Many practitioners within health and social care come into contact with people with intellectual disabilities and want to work in ways that are beneficial to them by making reasonable adjustments in order to meet clients’ needs and expectations. Yet the health and wellbeing of people with learning disabilities continues to be a neglected area, where unnecessary suffering and premature deaths continue to prevail. This text provides a comprehensive insight into intellectual disability healthcare. It is aimed at those who are training in the field of intellectual disability nursing and also untrained practitioners who work in both health and social care settings. Divided into five sections, it explores how a wide range of biological, health, psychological and social barriers impact upon people with learning disability, and includes: Six guiding principles used to adjust, plan and develop meaningful and accessible health and social services Assessment, screening and diagnosis of intellectual disability across the life course Addressing lifelong health needs Psychological and psychotherapeutic issues, including sexuality, behavioural and mental health needs, bereavement, and ethical concerns. The changing professional roles and models of meeting the needs of people with intellectual and learning disabilities. Intellectual Disability in Health and Social Care provides a wide-ranging overview of what learning disability professionals’ roles are and provides insight into what health and social care practitioners might do to assist someone with intellectual disabilities when specific needs arise.

Autism Spectrum Disorder is one of the most researched and popular topics in the fields of psychology, psychiatry, and special education. In the last 30 years the amount of new information on assessment and treatment has been astounding. The field has moved from a point where many considered the condition untreatable to the current position that it may be curable in some cases and that all persons with this condition can benefit from treatment. Intervening with school age children continues to be a major focus of assessment or intervention. However, expanding the ages of those receiving more attention from younger children to older adults, is becoming more prevalent. The consensus is that intensive treatment at the earliest recognized age is critical and that many adults evince symptoms of the disorder and warrant care. The field is full of many proposed treatments many of which offer promise but no data. Thus, a book on evidence-based assessments and interventions, across the life span should be of value in helping to sort out the more credible interventions as defined by the research and what methods have the best support. Given the popularity of the topic and the vst array of potential assessments and teratments available, this volume will be aimed at delineating what the researchers have shown has the best evidence to support particular methods. International Review of Research in Mental Retardation is now available online at ScienceDirect — full-text online of volumes 23 onwards. Elsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier’s extensive researcher network. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/bookseries/

"This book has an unusual format, and its intentions and underlying constructions are stimulating. This is a critical text that should be required reading for all students of health, disability, social medicine, therapy and nursing programmes. At the price, currently £19.99, it represents excellent value for money and is affordable for individual students to purchase." Learning Disability Practice "This could have been a triumphant book; instead it is a sober one, and far more useful for it … Based on an around-the-world tour of countries where the concepts of normalization and Social Role Valorization have been influential, the book offers a comparative account of the ways these ideas have worked out in seven different national contexts more than thirty years after their introduction." From the Foreword by John O’Brien, The Centre on Human Policy, Syracuse University, USA "In addition to its useful comparative approach this text demystifies and clarifies a number of complex issues." Iain Carson, University of Manchester, UK How do services in different countries vary across the lifespan? What lessons can the different countries learn from one another? Based on the author’s own experience from over thirty years in the field, this thought-provoking book offers a comparative study of services for people with intellectual disabilities in seven countries: England, Australia, Canada, New Zealand, Norway, Sweden and the USA. Through the author’s discussions with people with intellectual disabilities, parents and families, and those involved with services at a professional and academic level, the book provides a critical reflection on intellectual disability services across the lifespan. Each chapter contains the following key features: A brief ‘Instant Impacts’ reflection of an incident or a person encountered in the country concerned A short history of services in the country and a summary of the current service system A detailed look at services through the age range, including issues around screening and pre-birth Drawing on the author’s own experience of being a parent of a child with intellectual disabilities, ‘Adam’s World Tour’ boxes include a summary of the author’s views on the likely services Adam might receive in the country concerned Intellectual Disability is key reading for students of social work, learning disability nursing, social policy and community work, as well as those training to work with people with intellectual disabilities in health and social care services. Because of its unique approach, however, it is as relevant to families of people with intellectual disabilities as it is to professionally qualified practitioners and policy makers.

This book reviews important neuropsychological measures currently used in the assessment of dementia by the principal clinicians and researchers associated with the test, offering practical guidance on each test along with an analysis of its limitations.

Focuses entirely on health care of people with Down Syndrome throughout their life span, from birth to old age. With the remarkable strides that have been made in research and medicine in the past decade, people with Down Syndrome are living longer and healthier lives and are actively participating in all aspects of community life. Health care is a critical factor in this process. The first section explores the genetic basis for Down Syndrome as well as discusses speech and language development in children; the second section highlights clinical advances in treatment.

This book is the third in a series with the International Association for the Scientific Study of Intellectual Disabilities (Series Editor: Matthew P. Janicki). These publications are designed to address the issues of health, adult development and aging among persons with intellectual disabilities. For many years it has been recognized that some adults with intellectual disabilities are at elevated risk for mental and behavioral health problems. Often the aging process can complicate the identification, diagnosis, treatment and prevention of this type of dual diagnosis and present complex challenges to clinicians and carers. This book is designed as a practical resource for those involved with the support, care and treatment of persons with intellectual disabilities, and should prove particularly useful as this community achieves increased longevity. The book is divided into three parts: Prevalence and Characteristics; Diagnosis and Treatment; and Service System Issues.