Intraoperative Frozen Sections

Intraoperative Frozen Sections presents diagnostic challenges involved in the evaluation in the pathology lab of specimens obtained during surgery through the case experience of expert pathologists. Sixty-three problems cover the wide range of problems encountered in intraoperative consultations. Each presentation provides the case information as presented to the consultant, the evaluation and analysis of the specimen, discussion of the results and teaching points observed in the case, and an overall comment providing additional context for the diagnostic problem that has been presented. This problem-oriented format makes the book a superb reference resource for the working diagnostician and an ideal teaching tool for the resident or fellow. Coverage includes pediatric specimens and there is a section describing recognition of artifacts. Each case presentation is supported by several high-quality color photomicrographs with detailed explanations of each image, including images of the permanent sections and immunostains where applicable. Features of Intraoperative Frozen Sections include: Cases outline expert approach to diagnostic problems and technical issues most likely to be encountered in frozen section analysis Coverage includes pediatric specimens and recognition of artifacts Special emphasis on difficult problems and avoiding diagnostic pitfalls Provides common differential diagnoses for specific lesions seen in frozen section analysis (e.g. mimics of renal neoplasia) Nearly 500 high-quality color photomicrographs and detailed discussions of diagnostic features of each image "

This book provides guidance regarding the approach to common scenarios encountered in the frozen section laboratory while underscoring diagnostic pitfalls and providing the proper level of diagnostic information to ensure clear communication. Given the use of frozen section in molecular and research pathology, the text also serves as a guide for morphologic examination. Written by experts in the field, the book is organized according to organ system with additional chapters discussing the roles of digital pathology and molecular assays. Each chapter is extensively illustrated to highlight key points that facilitate interpretation and highlight areas for potential error. The goal of this book is to help trainees understand the need for mastery of this unique diagnostic tool, and to aid pathologists who cover frozen section convert practical information provided into diagnostic improvements. Frozen Section Pathology is a comprehensive and state-of-the-art review and serves as a valuable resource for the general surgical pathologist with frozen section responsibilities as well as surgeons who regularly utilize frozen section.

Frozen section of Neuropathology-related cases is performed while the patient is undergoing surgery. Intraoperative consultation is used to help guide intraoperative management of the case and to ensure that adequate and appropriate tissue has been obtained for purposes of making an accurate final diagnosis. Frozen section diagnosis is often a highly demanding situation for the pathologist, who must render a diagnosis quickly and provide sound guidance and advice. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissue that can be examined in a more leisurely fashion. Most standard pathology textbooks focus primarily on permanent section material and largely ignore the topic of frozen section. The purpose of this volume is to add to the Frozen Section Library series and provide a convenient, user friendly handbook to assist in the evaluation of central nervous system related frozen sections. It provides a useful reference, organized around differential diagnoses, primarily by location in the central nervous system. The text will be illustrated with color pictures and include tables as appropriate. This text provides a valuable tool for the practicing surgical pathologist both in community and in academic centers as well as pathology residents and fellows in training when confronted with Neuropathology frozen section.

The second edition of this well-received book provides detailed information on the basic and advanced laboratory techniques in histopathology and cytology. It offers clear guidance on the principles and techniques of routine and special laboratory techniques. It also covers advanced laboratory techniques such as immunocytochemistry, flow cytometry, liquid-based cytology, polymerase chain reactions, tissue microarray, molecular technology, etc. The book's second edition covers several important recent topics with many new chapters, such as liquid biopsy, artificial neural network, digital pathology, and next-generation sequencing. Each chapter elucidates basic principle, practical methods, troubleshooting, and clinical applications of the technique. It includes multiple colored line drawings, microphotographs, and tables to illustrate each technique. The book is a helpful guide to the post-graduate students and fellows in pathology, practicing pathologists, as well as laboratory technicians, and research students.

Offering expert guidance on the practical use of the frozen section in the management of clinical problems, Biopsy Interpretation: The Frozen Section, 3rd Edition, is a highly illustrated, authoritative reference on this intraoperative consultative option. New editor Dr. Nicole A. Cipriani, along with Drs. Aliya N. Husain, Jerome B. Taxy, and a team of expert contributing authors, focus not only on how to view and interpret a slide, but also when to do a frozen section. Fully up to date with extensive new content and images, this third edition emphasizes intraoperative consultation and patient management, explaining the role the general surgical pathologist can play in the treatment of patients.

Frozen sections are performed while a patient is undergoing surgery as a basis for making an immediate diagnosis that will impact treatment decisions. Frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly, based on careful gross examination of specimens to select optimal areas for microscopic examination. The Frozen Section Library series will provide concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario. Donna M. Coffey, M.D., is Assistant Professor, Department of Pathology and Laboratory Medicine, The Methodist Hospital, Houston, Texas and Weill Medical College of Cornell University, New York, New York. Ibrahim Ramzy, M.D., is Professor of Pathology - Laboratory Medicine & Obstetrics-Gynecology, University of California, Irvine, California and Adjunct Professor of Pathology, Baylor College of Medicine, Houston, Texas.

The 678 page book is a highly illustrated guide for the intra-operative interpretation of central nervous system surgical specimens. Both of the two principal techniques - smear preparations and frozen sections - are described in great detail. Introductory chapters address general approaches to specimen acquisition and preparation; specific clinical and radiological features; differential diagnosis by site; tumor and non-tumor entities with specific pathological features; and normal cells and tissues potentially mistaken for abnormalities. The bulk of the text describes specific clinicopathological entities, in over 80 chapters. Most of the latter present bulleted summaries of clinical and radiological features, similarly formatted sections on cytological (smear preparations) and histological (frozen sections) findings, and detailed differential diagnoses. There are over 1500 illustrations, including radiological images, operative photographs, and, largely, color photomicrographs of smears and frozen sections. Throughout, the book illustrates the practical aspects of real-time, real-world cytological and histological diagnoses. The book is a unique resource derived from the author's over three decades of experience in the intra-operative diagnosis of central nervous system lesions. Designed primarily for pathologists, it will be extremely useful for neurosurgeons as well, in their formulations of a differential diagnoses based of lesions' sites, radiological anatomy, and pathological features.

This atlas is dedicated specifically to gynecologic frozen section diagnosis and addresses professional practice gaps such as high diagnostic error rate, slow turnaround time, and inefficient communication between surgeons and pathologists at the time of intraoperative frozen section consultation of gynecologic specimens. The format of the volume is a combination of concise text and high quality gross and frozen section microscopic images, meticulously selected from the superb collection of pathology specimens of gynecologic tumors provided at Yale-New Haven Hospital in the past decades. Frequent entities with diagnostic pitfalls are balanced with less common lesions. Strategies to recognize their diagnostic features are emphasized, in addition to the impact on optimal surgical treatment of patients with gynecologic cancer. The indications, limitations, morphologic diagnostic criteria and pitfalls of frozen section consultation in gynecologic pathology are thoroughly reviewed with an ultimate goal of avoiding patient mismanagement in real-time. High quality frozen section microscopic illustrations aid the recognition of morphologic patterns and serve as quick reference during intraoperative consultation. Written by experts in the field, Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology is a valuable resource for pathologists at all career/expertise levels who are involved in intraoperative consultation in their daily clinical practice.