Journal Of The American Statistical Association

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

From the preface The "threshold p-value"-the arbiter of statistical significance-has been a widely used gateway to believability and acceptance for publication in scientific research since 1925. However, a growing number of statisticians and other researchers say we should "move beyond" these ideas, suggesting we should greatly reduce our emphasis on them in scientific research. These authors are waging a well-intentioned, polite, and vigorous intellectual war on the ideas of a threshold p-value and statistical significance. This is a "good" war, because it forces important issues into the open, where they can be best understood and assessed. This book grew from a sense that the threshold-p-value gateway to publication of scientific research results is highly useful but is also widely misunderstood. The book presents, from first principles, a modern view of the role of the gateway, as used by some scientific journals. The ideas are explained in terms of the recent disagreement about them between the editorial in a Special Issue on Statistical Inference of the American Statistician and a subsequent editorial in the New England Journal of Medicine. The ideas are developed with almost no reference to mathematics. (A computer can do all the standard math if the user properly understands the key ideas.) The explanations are reinforced with practical examples. The discussion shows how the concept of a threshold-p-value gateway helps researchers and journal editors maximize the overall scientific, social, and commercial benefit of scientific research. The gateway does this by optimally balancing the rates of costly "false-positive" and "false-negative" errors in a scientific journal. The book also discusses the important related ideas of a relationship between variables, a scientific hypothesis test, and the "replication crisis" in some branches of scientific research. The body of the book, which covers the key ideas, is roughly 30% of the text. The remainder consists of 23 appendices that expand the ideas in useful directions. The material is aimed at scientific researchers, journal editors, science teachers, and science students in the biological, social, and physical sciences. It will also be of interest to statisticians, data scientists, philosophers of science, and lay readers seeking an integrated modern view of the high-level operation of the study of relationships between variables in scientific research. About the author Donald B. Macnaughton has been a statistical consultant for more than 40 years. He has managed the statistical aspects of research in the fields of experimental psychology, zoology, drug dependence, nursing, education, business, geography, physical education, and inmate rehabilitation, among others. His consulting work supports and informs his main interest, which is to read, understand, and write about the vital role of the field of statistics in scientific research.

Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular situations often encountered in practice. This book aims to gather in a single reference the most commonly used extensions, such as frailty models (in case of unobserved heterogeneity or clustered data), cure models (when a fraction of the population will not experience the event of interest), competing risk models (in case of different types of event), and joint survival models for a time-to-event endpoint and a longitudinal outcome. Features Presents state-of-the art approaches for different advanced survival models including frailty models, cure models, competing risk models and joint models for a longitudinal and a survival outcome Uses consistent notation throughout the book for the different techniques presented Explains in which situation each of these models should be used, and how they are linked to specific research questions Focuses on the understanding of the models, their implementation, and their interpretation, with an appropriate level of methodological development for masters students and applied statisticians Provides references to existing R packages and SAS procedure or macros, and illustrates the use of the main ones on real datasets This book is primarily aimed at applied statisticians and graduate students of statistics and biostatistics. It can also serve as an introductory reference for methodological researchers interested in the main extensions of classical survival analysis.