Late Phase Allergic Reactions

This important publication presents new information regarding "Late Phase Allergic (or Inflammatory) Reactions" (LPR). It includes present knowledge on the pathogenesis of LPR in human skin, nose, bronchi, and other organ systems. The book discusses the roles of antibodies, mediators, and cells as well as animal models of LPR. It describes the importance of LPR in the pathogenesis of chronic disease and the possibilities of their pharmacological modulation. The authors discuss clinical conclusions to be drawn from the observation of LPR, such as continuous treatment and immunotherapy. This volume is a useful reference for scientists and clinicians wishing to understand more about the problems of their allergic patients.

Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

Through real-life stories, learn about the many types of allergies and their effects, including asthma, hay fever, food allergies, latex allergies, and anaphylaxis. Understand how the immune system works and how different people react to allergens. Explore the history, symptoms, diagnosis, treatment, prevention, and future areas of research for those with allergies.

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.

Abstract: This primary textbook and reference source provides information on recent developments in allergy and immunology to clinicians and laboratory scientists. Volume I is concerned with basic information on the immunology, physiology, and pharmacologic aspects of allergic disease and includes data on the basic mechanisms involved in allergic disease and the biology of the cell types involved in allergic reactions. Volume II is the clinical science section and covers the essential clinical diagnostic, and therapeutic aspects of allergic disease. These articles are extensively referenced.

The ability to monitor allergic inflammation has improved considerably in recent years due to the identification of numerous factors involved in the regulatory network of inflammatory response. As research has progressed, it has become clear that the subject is more complex than was originally believed, and a symposium was organized to bring together leading experts in the area and to review current knowledge. This book contains reports that were presented at the meeting and includes discussions of human B cell activation, cytokines and anticytokines, neuropeptides, asthma, cellular and molecular processes, and the roles of mast cells, basophils, eosinophils, neutrophils, macrophages, and platelets in inflammation. It will be essential reading for all those engaged in research in immunology, allergy, and asthma. Research level Symposium proceedings covering important topics in: Allergy Inflammation Asthma

This book explores the cellular and molecular mechanisms involved in asthma and allergic diseases, from basic immunology to the treatment of patients. Arising from a special symposium held to celebrate Professor A. Barry Kay's 20th anniversary as Head of the Department of Allergy and Clinical Immunology at the National Heart and Lung Institute, London, the publication presents 18 review articles by an impressive cross section of experts in the field. Topics considered include Th1 and Th2 cells, the regultion of Th2 cytokine transcription, the role of T cells in the immunopathogenesis of asthma, and MHC-restricted IgE-independent T-cell-induced late-phase responses in human subjects. Further chapters focus on eosinophil adhesion and activation, the role of C-C chemokines in the recruitment of eosinophils, and the interactions between eosinophils and fibroblasts. T-cell recruitment and T-cell interactions in cutaneous basophil hypersensitivity and fibrotic lung disease are discussed, as is the molecular pathology of allergic disease. Finally, treatment approaches are considered in chapters on the molecular basis of corticosteroid actions in asthma, immunosuppression in asthma, and immunotherapy of allergic diseases.