Leksell Radiosurgery

Since its introduction 52 years ago, Leksell radiosurgery has become a widely applied technique for the management of a diverse group of vascular, neoplastic, and functional disorders. This publication presents an update on state-of-the-art radiosurgery technology, including outcomes, by the pioneers in the field. Experts have contributed chapters on various topics. They provide a history of the development of Leksell Gamma Knife and its evolution from frame-based to the inclusion of mask-based radiosurgery in the latest Gamma Knife model. For beginners, there is valuable information related to imaging, quality assurance, patient care, anesthesia, and regulatory requirements. Advance users will appreciate the summary of the long-term outcome of important indications. Additional chapters on cavernous malformation, orbital, uveal, and ocular disorders clarify the role of radiosurgery. This book is a concise overview for physicians interested in radiosurgery. It will be of great value to neurosurgeons, radiation oncologists, and medical physicists concerned with learning about the indications of radiosurgery.

As in any multiauthored textbook penned by When I was first approached by the publisher of this volume, Martinus Nijhoff, Boston, I writers of diverse backgrounds and interests, explored the possibility of writing a personal Modern Stereotactic Neurosurgery to some monograph on contemporary stereotactic extent suffers from incompleteness. Future surgery. After a review of available literature, volumes no doubt will include many additions several aspects became apparent. First, no cur from other authors who also are important rent, readily accessible, multiauthored text de specialists in the field. Because not all authors signed to survey the field was available. Those write in the same style (or even language), we books that were available tended to heavily have attempted to achieve a more cohesive text emphasize theory, physiology, and anatomy. in the editorial process. Each chapter has been Second, stereotactic surgeons were considered subdivided into pertinent headings for easier abstruse and for too long were relegated to a reference. Because of my own background, status outside of the mainstream of neuro some readers will note an Americanization (as surgery. This attitude probably reflected the opposed to anglicization) of the chapters. insufficient explanation of the practical uses While many chapters comprise primarily sum and advantages of stereotactic technique. maries of the authors' work within the field, Third, in recent years, the field has expanded each author was encouraged to review the liter so rapidly that it has become a major compo ature in that discipline if appropriate.

This publication aims to give comprehensive information on the methods of gamma knife radiosurgery and the results of treatment of the most frequent diagnoses using radiosurgery. A summarisation of existing knowledge and results obtained in gamma knife radiosurgery world-wide is based on experience with treatment of more than 13,500 patients over 20 years at Na Homolce Hospital, Prague. Besides detailing the basic data of Leksell gamma knife radiosurgery, this book also provides thorough technical description of former and existing gamma knife models, basic physics principles of gamma knife radiosurgery, calibration and quality assurance as well as standardised treatment procedures. The book is primarily intended for physicians, who, together with the patient decide on the most appropriate methods of treatment for each diagnosis. The publication can be also helpful to medical physicists who are involved in gamma knife radiosurgery and responsible for its calibration and quality assurance. Finally, it is also intended for patients who are looking for, if necessary, more comprehensive information on the radiosurgical treatment method for tumours and other brain disorders.

In this third edition of Intracranial Stereotactic Radiosurgery, Drs. Sheehan and Lunsford provide an updated assessment of the practice of stereotactic radiosurgery. Topics include benign and malignant tumors, cerebrovascular abnormalities, and functional disorders. Several new topics are now included and focus on immunotherapy, hypofractionation, and repeat radiosurgery. Each chapter contains key figures and tables to illustrate the critical concepts of the work. Contributors to the book represent many of the most prestigious stereotactic radiosurgery centers across the world. This book is comprised of 36 chapters and represents a comprehensive update to prior editions. It is intended to be a readable, credible, and accessible reference on stereotactic radiosurgery. Editors Jason Sheehan, MD, PhD, FACS, FAANS, is the Vice Chair and Harrison Distinguished Professor of Neurological Surgery at the University of Virginia (UVA). He also serves as the Neurosciences Service Line Director at UVA. Dr. Sheehan is the current chair of the American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS) Section on Tumors. He serves as the Editor-In-Chief of the Journal of Neuro-Oncology. L. Dade Lunsford, MD, serves as the Lars Leksell Professor and Distinguished Professor at the Department of Neurological Surgery at the University of Pittsburgh. He is also director of the Center for Image-Guided Neurosurgery at the University of Pittsburgh Medical Center and an internationally recognized authority on stereotactic surgery, radiosurgery, and minimally invasive surgery. He has authored or coauthored more than 1,000 scientific reports and 16 books.

Written by internationally known experts in the field, Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy examines one of the fastest-developing subspecialties within radiation oncology. These procedures deliver large doses of radiation in one to five sessions to a precisely determined target. Often these techniques have proven to be as or more effective than traditional radiation therapy techniques, while at the same time being cost-efficient and convenient for the patient. These techniques, however, require careful planning, specialized equipment, and well-trained staff. This volume provides a cutting-edge look at the biological and technical underpinnings of SRS and SBRT techniques. It includes a history of the development of SRS and SBRT; clinical applications of the techniques; dedicated devices for delivering precisely shaped, high doses of radiation; use of in-room imaging for treatment planning and treatment guidance; immobilization techniques for accurate targeting; and future developments that will continue to evolve and refine existing techniques. A valuable introduction to those just learning about these specialized techniques, and an ideal reference for those who are already implementing them, this book covers a wide variety of topics, with clear discussions of each aspect of the technology employed.

Written by recognized experts in the fields of neurologic surgery, neurology, physics, and radiation oncology, Intracranial Stereotactic Radiosurgery is a comprehensive reference for current techniques for radiosurgery of the brain. Following introductory chapters on the relevant history, radiobiology, and neuropathology of radiosurgery, the book provides detailed discussion of radiosurgical procedures for various disease entities, including arteriovenous malformations and fistulas, meningiomas, vestibular and nonvestibular schwannomas, movement disorders, epilepsy, ocular disorders, and brain metastases. These chapters address the benefits and limitations of radiosurgical techniques for each indication and describe the outcomes, possible complications and their management, and alternative treatments.Highlights: Review of all currently available treatment systems Discussion of frame-based versus frameless techniques Coverage of single and multisession radiosurgery with descriptions of indications and benefits of each approach More than 100 high-quality illustrations, many in full color Perspectives from international experts in the field This authoritative textbook will be invaluable to neurosurgeons, radiation oncologists, neuroradiologists, and medical physicists at all levels. It is also a helpful resource for neurologists and other physicians who refer patients for intracranial radiosurgery.

The History of the Gamma Knife presents the evolution of concepts and technology which ended in the production of the modern Gamma Knife. The story starts before the Second World War and links pioneers in Berkeley and Sweden. To the best of the author’s belief it is the first detailed, factually accurate account of the development of this important therapeutic method. The author has been involved in Gamma Knife surgery since the early days and has written 3 books and many papers on the topic The author is fluent in Scandinavian languages and knows the original pioneers in the field and has consulted with them to ensure the story is accurate The book is written in an informal easy to read style The book fills a vacuum in the literature. There are many short accounts of a few pages but no hopefully definitive account of the story of the Gamma Knife. Also these short accounts all too often contain errors which hopefully are absent from the current text

This book is a comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients. Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the Leksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Detailed images and charts enhance the chapters. This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.