Machine Learning Techniques On Gene Function Prediction Volume Ii

This book is open access under a CC BY 4.0 license This open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension.The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.

Currently, machine learning is playing a pivotal role in the progress of genomics. The applications of machine learning are helping all to understand the emerging trends and the future scope of genomics. This book provides comprehensive coverage of machine learning applications such as DNN, CNN, and RNN, for predicting the sequence of DNA and RNA binding proteins, expression of the gene, and splicing control. In addition, the book addresses the effect of multiomics data analysis of cancers using tensor decomposition, machine learning techniques for protein engineering, CNN applications on genomics, challenges of long noncoding RNAs in human disease diagnosis, and how machine learning can be used as a tool to shape the future of medicine. More importantly, it gives a comparative analysis and validates the outcomes of machine learning methods on genomic data to the functional laboratory tests or by formal clinical assessment. The topics of this book will cater interest to academicians, practitioners working in the field of functional genomics, and machine learning. Also, this book shall guide comprehensively the graduate, postgraduates, and Ph.D. scholars working in these fields.

Refuel your AI Models and ML applications with High-Quality Optimization and Search Solutions DESCRIPTION Genetic algorithms are one of the most straightforward and powerful techniques used in machine learning. This book ÔLearning Genetic Algorithms with PythonÕ guides the reader right from the basics of genetic algorithms to its real practical implementation in production environments.Ê Each of the chapters gives the reader an intuitive understanding of each concept. You will learn how to build a genetic algorithm from scratch and implement it in real-life problems. Covered with practical illustrated examples, you will learn to design and choose the best model architecture for the particular tasks. Cutting edge examples like radar and football manager problem statements, you will learn to solve high-dimensional big data challenges with ways of optimizing genetic algorithms. KEY FEATURESÊÊ _ Complete coverage on practical implementation of genetic algorithms. _ Intuitive explanations and visualizations supply theoretical concepts. _ Added examples and use-cases on the performance of genetic algorithms. _ Use of Python libraries and a niche coverage on the performance optimization of genetic algorithms. WHAT YOU WILL LEARNÊ _ Understand the mechanism of genetic algorithms using popular python libraries. _ Learn the principles and architecture of genetic algorithms. _ Apply and Solve planning, scheduling and analytics problems in Enterprise applications. _Ê Expert learning on prime concepts like Selection, Mutation and Crossover. WHO THIS BOOK IS FORÊÊ The book is for Data Science team, Analytics team, AI Engineers, ML Professionals who want to integrate genetic algorithms to refuel their ML and AI applications. No special expertise about machine learning is required although a basic knowledge of Python is expected. TABLE OF CONTENTS 1. Introduction 2. Genetic Algorithm Flow 3. Selection 4. Crossover 5. Mutation 6. Effectiveness 7. Parameter Tuning 8. Black-box Function 9. Combinatorial Optimization: Binary Gene Encoding 10. Combinatorial Optimization: Ordered Gene Encoding 11. Other Common Problems 12. Adaptive Genetic Algorithm 13. Improving Performance

This book discusses topics related to bioinformatics, statistics, and machine learning, presenting the latest research in various areas of bioinformatics. It also highlights the role of computing and machine learning in knowledge extraction from biological data, and how this knowledge can be applied in fields such as drug design, health supplements, gene therapy, proteomics and agriculture.

Machine Learning in Bioinformatics of Protein Sequences guides readers around the rapidly advancing world of cutting-edge machine learning applications in the protein bioinformatics field. Edited by bioinformatics expert, Dr Lukasz Kurgan, and with contributions by a dozen of accomplished researchers, this book provides a holistic view of the structural bioinformatics by covering a broad spectrum of algorithms, databases and software resources for the efficient and accurate prediction and characterization of functional and structural aspects of proteins. It spotlights key advances which include deep neural networks, natural language processing-based sequence embedding and covers a wide range of predictions which comprise of tertiary structure, secondary structure, residue contacts, intrinsic disorder, protein, peptide and nucleic acids-binding sites, hotspots, post-translational modification sites, and protein function. This volume is loaded with practical information that identifies and describes leading predictive tools, useful databases, webservers, and modern software platforms for the development of novel predictive tools.