Management Of Heart And Lung Transplant Patients

A comprehensive text from the leading transplant centres on the medical management of thoracic organ transplantation, covering the assessment of patients for possible transplantation, through to managing patients after transplantation including any possible complications and shared care aspects of long term management

This issue of Critical Care Clinics, Guest Edited by Dr. Kenneth McCurry and Dr. Ali Al-Khafaji, focuses on Critical Care of the Solid Organ Transplant Patient. Dr. McCurry’s section of the issue is devoted to Heart and Lung Transplants and includes the following topics: Long term outcomes of transplantation; Mechanical ventilation; Pulmonary hypertension therapy; Extracorporeal membrane oxygenation; Perioperative management of the lung graft following lung transplantation; Perioperative management of the heart graft following heart transplantation; Renal complications following lung and heart transplantation; and Infection and other complications following transplanation. Dr. Al-Khafaji’s section of the issue is devoted to Liver, Kidney, and Small Bowel Transplants and includes the following topics: The immediate postoperative period; Live donor liver transplant; Graft dysfunction and management; Extracorporeal devices; Infectious complication following solid organ transplants; and Cardiac, renal, neurological, and gastrointestinal complications.

Textbook of Transplantation and Mechanical Support for End-Stage Heart and Lung Disease Comprehensive textbook covering all aspects of the care of patients with advanced heart or lung disease Transplantation and Mechanical Support for End-Stage Heart and Lung Disease is the most comprehensive and contemporary textbook available that addresses the medical and surgical treatment options for patients with end-stage heart and lung disease. All facets of these complex and resource-intensive therapies are covered by leading experts — including the basics of transplant immunology, databases, regulatory and ethical aspects of transplantation and conventional and new modalities of donor organ harvest. Transplantation and Mechanical Support for End-Stage Heart and Lung Disease includes further information on topics such as: Historical developments that facilitated heart and lung transplantation; engineering advances in continuous flow technologies Transplant organizations, oversight, structure, process, databases and registries in the thoracic transplants and MCS field Current strategies in immune modulation, desensitization protocols and mechanisms of allograft rejection and tolerance/immunosenescence Detailed descriptions of donor and recipient surgical procedures as well as comprehensive implantation techniques for all available short- and long-term mechanical circulatory support devices, including ECMO Organ allocation and prioritization, donor evaluation, high risk donors, marginal donors, and risk assessment Richly enhanced with summary tables and color illustrations to provide an engaging and supportive learning experience, the book will serve as a highly valuable source of contemporary knowledge for medical students, residents, nurses, perfusionists, physicians and surgeons involved in the care of these desperately ill group of patients. “This comprehensive book covers all aspects of advanced heart and lung failure treatment, including shock, short-term and durable mechanical assistance, as well as transplantation. The in-depth information will be welcome by newcomers in the field as well as seasoned veterans.” —Andreas Zuckermann, M.D Vice-Chair, Department of Cardiac Surgery, Director of Cardiac Transplantation Program, Medical University of Vienna, Vienna General Hospital “This comprehensive tour-de-force compendium covers practical issues of clinical administration, program development, care pathways, ongoing challenges and opportunities in each treatment area as a must go-to reference for guidance in the rapidly evolving fields of mechanical circulatory support and transplantation.” —Mandeep R. Mehra, MBBS, MSc, FRCP Executive Director, Center for Advanced Heart Disease, Brigham and Women’s Hospital, Harvard Medical School “This unique textbook authored by key opinion leaders is a refreshing ???wind of change??? in our field, one that will well serve all professionals involved in the care of end-stage heart and lung patients for many years to come.” —Marcelo Cypel MD, MSc, FACS, FRCSC Surgical Director Ajmera Transplant Centre at UHN , University of Toronto

It is a great pleasure for me to contribute a few words as an achieved by many heart transplant centers and the ever improving results of lung transplantation and the functioning of mechanical introduction to the second edition of this volume, first published in 1990 when it was edited by David Cooper and Dimitri cardiac assist devices. Novitzky. The first edition was, in fact, a greatly expanded The current editors bring a wealth of expertise and experience version of an even earlier volume Heart Transplantation, edited to their task, and have blended together absolutely superb con by David Cooper and Robert Lanza and published in 1984. This tributions by many of the world's experts in their fields. This first work, authored by members of the medical staff of Groote comprehensive and highly readable volume documents the Schuur Hospital and the University of Cape Town Medical present 'state of the art' in the field of transplantation and School, was, I believe, the first volume reviewing this relatively replacement of thoracic organs. It provides an invaluable and un new field of medicine. paralleled source of information for those concerned with heart and lung medicine or surgery, and is essential reading for all who The present volume, therefore, continues the documentation of wish to keep abreast of developments in this field.

Saving lives through organ transplantation has become increasingly possible thanks to advances in research and care. Today, the complex field of transplantation continues to develop rapidly, fuelled by demographic change and further evolutions in scientific understanding. The Oxford Textbook of Transplant Anaesthesia and Critical Care has been written and edited by pioneers in the field of organ transplantation with an international team of authors, in order to equip anaesthetists and intensivists with the knowledge and training necessary to provide high quality and evidence-based care. The text addresses fundamentals aspects of scientific knowledge, care of the donor patient, transplant ethics and special considerations. Dedicated sections address each of the major organs; kidney, pancreas, liver, heart and lung, intestinal and multivisceral. Within each organ-based section, expert authors explore underlying disease, planning for transplantation, specialized procedures, perioperative and critical care management as well as post-transplant considerations. Focus points for future developments in transplant immunology are also set out, inspiring current practitioners to engage with current clinical research and help participate in the further advancement of the science of transplantation. The print edition of the Oxford Textbook of Transplant Anaesthesia and Critical Care comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.

An excellent resource for practitioners who participate in the care of transplant patients, this comprehensive new second edition covers all aspects of heart and lung transplantation. Each area of the field is fully addressed, with documentation and practical points for patient management provided throughout. An especially notable feature of this new edition is the greatly expanded coverage of lung transplantation, with every chapter rewritten to reflect changes to current information in the field. Complete coverage of all aspects of heart and lung transplantation, including evaluation and management of transplant patients, anesthetic and operative techniques, postoperative care, biopsy techniques, immunosuppressive management, long-term management, and pediatric transplantation. Thorough discussions of programmatic issues, donor evaluation and graft preservation, morbidity associated with transplantation, and future implications. Contributions from renowned experts, many from Johns Hopkins University and Stanford University. Includes two new editors: Edward Kasper, MD and James Theodore, MD. Offers significantly expanded coverage on lung transplantation, sections on single lung transplantation, current rejection management, new operative techniques, and effective patient care. Presents several new chapters including: Medical and Surgical Alternatives to Cardiac Transplantation (Ch. 8), Living Related Lung Transplantation (Ch. 43), Lung Pathology (Ch. 28), Immunosuppressive Therapy in the 21st Century (Ch. 48), and Management of Congestive Heart Failure in the 21st Century (Ch. 49). Covers new information on quality of care, circulatory support and Mechanical Circulatory Assistance Prior to Heart Transplantation (Ch. 12).

This is a concise review of up-to-date concepts and techniques in the discipline of heart transplantation. It is a review and reference for practitioners managing patients with advanced heart disease, including patients with end-stage heart failure, mechanical circulatory support or transplant recipients. Heart failure is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing heart failure is one in five. Heart failure carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. As heart transplantation remains the best treatment option for patients with end stage heart failure, this primer will provide valuable information and management strategies for physicians caring for these patients. Also, due to continued shortage in donor organs, heart transplantation is a limited resource – which further underscores the importance of appropriately evaluating patients for transplant candidacy and managing their pre, peri- and post-transplant care for maximum benefit and best outcomes.​

This book is a comprehensive overview of heart failure and cardiac transplantation and integrates scientific and clinical information about the physiology, pathophysiology, diagnosis, and treatment of this disorder. Organized into five parts, it reviews the history and basic mechanisms of heart failure; etiology of heart failure; heart failure disease progression; advanced therapies for heart failure; and cardiac transplantation. The book presents basic concepts in the physiology, molecular biology, pathology, and epidemiology of the normal and failing heart; known causes of heart failure, such as right heart failure, valvular cardiomyopathy, molecular mechanisms of sarcomeric cardiomyopathies, and neuromuscular cardiomyopathy; cardiorenal syndrome; neurohormonal activation; cardiac resynchronization, ventricular assist devices; regenerative mechanisms; orthotopic heart transplantation; early and late management of the post-transplant patient; heart transplantation and antibody-mediated rejections; heart-lung transplantation; and cardiac xenotransplantation. Featuring contributions from leaders in the fields of heart failure, cardiac transplantation, cardiac pathology, and cardiovascular molecular research, Congestive Heart Failure and Cardiac Transplantation is a valuable compendium for cardiologists, cardiothoracic surgeons, researchers, trainees, and students.