Markers

A purple marker shows his friends that being creative means sometimes coloring outside the lines in When Pencil Met the Markers, the imaginative, inspiring, and colorful follow-up to When Pencil Met Eraser from writers Karen Kilpatrick and Luis O. Ramos, Jr., and illustrator German Blanco. Meet the Markers! They love to color. But Purple Marker colors everywhere—even outside the lines. When the other markers call his creativity a mistake, it’s up to Pencil and Eraser to help Purple discover how making mistakes and making art go hand-in-hand. This hilarious and clever picture book allows Pencil and Eraser to show Purple Marker—and the rest of us—how to turn our messes into successes and do what makes us happy. When Pencil Met the Markers brings engaging art, adorable characters, and a clever story to the everyday. The result? A funny, effective message about how the best art can come from trying something new. An Imprint Book An Amazon Best Book of the Month

Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markersâ€"sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.

Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).

Discover how easy it is to successfully use markers for beautiful coloring, sketching, illustration, mixed media, and more. All you need to get started is this creative workbook from Hello Angel.

The double helix architecture of DNA was elucidated in 1953. Twenty years later, in 1973, the discovery of restriction enzymes helped to create recombinant DNA molecules in vitro. The implications of these powerful and novel methods of molecular biology, and their potential in the genetic manipulation and improvement of microbes, plants and animals, became increasingly evident, and led to the birth of modern biotechnology. The first transgenic plants in which a bacterial gene had been stably integrated were produced in 1983, and by 1993 transgenic plants had been produced in all major crop species, including the cereals and the legumes. These remarkable achievements have resulted in the production of crops that are resistant to potent but environmentally safe herbicides, or to viral pathogens and insect pests. In other instances genes have been introduced that delay fruit ripening, or increase starch content, or cause male sterility. Most of these manipulations are based on the introduction of a single gene - generally of bacterial origin - that regulates an important monogenic trait, into the crop of choice. Many of the engineered crops are now under field trials and are expected to be commercially produced within the next few years. The early successes in plant biotechnology led to the realization that further molecular improvement of plants will require a thorough understanding of the molecular basis of plant development, and the identification and character ization of genes that regulate agronomically important multi genic traits.

This book is a contribution to the growing field of diachronic construction grammar. Focus is on corpus evidence for the importance of including conventionalized pragmatics within construction grammar and suggestions for how to do so. The empirical domain is the development of Discourse Structuring Markers in English such as after all, also, all the same, by the way, further and moreover (also known as Discourse Markers). The term Discourse Structuring Markers highlights their use not only to connect discourse segments but also to shape discourse coherence and understanding. Monofunctional Discourse Structuring Markers like further, instead, moreover are distinguished from multifunctional ones like after all and by the way. Drawing on usage-based work on constructionalization and constructional changes, the book is in three parts: foundational concepts, case studies, and currently open issues in diachronic construction grammar. These open issues are how to incorporate the concepts subjectification and intersubjectification into a constructional account of change, whether position in a clause is a construction, and the nature of constructional networks and how they change.

While discourse markers have been examined in some detail, little is known about their usage by non-native speakers. This book provides valuable insights into the functions of four discourse markers (so, well, you know and like) in native and non-native English discourse, adding to both discourse marker literature and to studies in the pragmatics of learner language. It presents a thorough analysis on the basis of a substantial parallel corpus of spoken language. In this corpus, American students who are native speakers of English and German non-native speakers of English retell and discuss a silent movie. Each of the main chapters of the book is dedicated to one discourse marker, giving a detailed analysis of the functions this discourse marker fulfills in the corpus and a quantitative comparison between the two speaker groups. The book also develops a two-level model of discourse marker functions comprising a textual and an interactional level.

Examining the syntax and semantics of discourse markers, this book employs a syntactic approach to describe discourse markers in Head-Driven Phrase Structure Grammar (HPSG), relevant in a theory of discourse because it provides a framework in which all levels of grammar can be integrated. Since discourse markers operate at discourse level, a well developed discourse theory is required - in this case, Segmented Discourse Representation Theory (SDRT) is adopted. During the course of the book, Minimal Recourse Semantics is explained as it provides an integration of HPSG and SDRT. The approach described is exemplified with an analysis of 'anyway'. This book provides a detailed overview of research on discourse markers covering different areas of linguistics: from a discourse analysis point of view, to a Relevance Theory perspective going through a computational linguistics approach. Containing a precise summary of HPSG and the recently developed SDRT, it will be of great interest to researchers in semantics, pragmatics, grammar and discourse analysis.