Marrow And Bone

A moving, darkly funny road trip novel about World War II, returning to one's birthplace, and coming to terms with tragedy. West Germany, 1988, just before the fall of the Berlin Wall: Jonathan Fabrizius, a middle-aged erstwhile journalist, has a comfortable existence in Hamburg, bankrolled by his furniture-manufacturing uncle. He lives with his girlfriend Ulla in a grand, decrepit prewar house that just by chance escaped annihilation by the Allied bombers. One day Jonathan receives a package in the mail from the Santubara Company, a luxury car company, commissioning him to travel in their newest V8 model through the People’s Republic of Poland and to write about the route for a car rally. Little does the company know that their choice location is Jonathan’s birthplace, for Jonathan is a war orphan from former East Prussia, whose mother breathed her last fleeing the Russians and whose father, a Nazi soldier, was killed on the Baltic coast. At first Jonathan has no interest in the job, or in dredging up ancient family history, but as his relationship with Ulla starts to wane, the idea of a return to his birthplace, and the money to be made from the gig, becomes more appealing. What follows is a darkly comic road trip, a queasy misadventure of West German tourists in Communist Poland, and a reckoning that is by turns subtle, satiric, and genuine. Marrow and Bone is an uncomfortably funny and revelatory odyssey by one of the most talented and nuanced writers of postwar Germany.

This book is a conversation starter. The author is re-imagining the theological landscape of historical practices of dance in order to open up a space where further explorations can be made. This is done in a two step manner. First, the book uncovers the restrictions of earlier research on the topic of dance in and around churches. In the second step, Hellsten suggests a practice for how historical sources can be imagined in a new frame. Opening up a new field of previously neglected and much needed historical studies on Dance in the Christian churches of the Latin West this study aims at questioning old paradigms and opening new vistas rather than reinterpreting concrete liturgical manuscripts or scrutinizing all the details of the historical sources presented.

This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis. After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body. This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders. The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms. The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification. This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

Just when you think you have nothing left to lose, they come for your dreams. Humanity has nearly destroyed its world through global warming, but now an even greater evil lurks. The indigenous people of North America are being hunted and harvested for their bone marrow, which carries the key to recovering something the rest of the population has lost: the ability to dream. In this dark world, Frenchie and his companions struggle to survive as they make their way up north to the old lands. For now, survival means staying hidden — but what they don't know is that one of them holds the secret to defeating the marrow thieves.

This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.

This book provides a highly illustrated and comprehensive account of the diseases of the human bone marrow. It will help experienced clinicians and those in training to answer the practical diagnostic questions that arise during the routine analysis of bone marrow core biopsy specimens. Throughout the text, histologic interpretation is integrated with clinical and laboratory findings. Emphasis is placed on the evaluation of peripheral blood, aspirate smear, clot section and core biopsy, as well as ancillary techniques including flow cytometry and immunohistochemistry in the diagnosis of hematologic disorders of the marrow. The text is illustrated with numerous color figures, charts and tables, and descriptions of real case situations using the most up-to-date classification systems. Illustrated Pathology of Bone Marrow should be read by all pathologists, hematologists and laboratory technicians involved in the analysis of bone marrow specimens.

Bone Marrow Processing and Purging: A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow transplantation. Previously, this information was communicated primarily by word of mouth; now experts in the field present detailed descriptions and evaluations of methods for marrow harvesting, evaluation (including tumor infiltration, flow cytometric analysis, and colony assays), comparative methods for automated nucleated cell separation and enumeration, tumor cell purging, T cell depletion, stem cell selection, gene transfer, and cytopreservation. Special sections address quality control and FDA regulations. The book provides a unique information source intended for clinicians, researchers, technical staff, transplant nurses, and medical students involved in this rapidly expanding area of medicine.