Max Perutz And The Secret Of Life

Few scientists have thought more deeply about their calling and its impact on humanity than Max Perutz (1914-2002). Born in Vienna, Jewish by descent, lapsed Catholic by religion, Max came to Cambridge in 1936, to join the lab of the legendary Communist thinker J.D. Bernal. In 1940 he was interned and deported to Canada as an enemy alien, only to be brought back and set to work on a bizarre top secret war project. Seven years later he founded the small research group in which Francis Crick and James Watson discovered the structure of DNA. Max Perutz himself explored the protein haemoglobin and his work, which won him a shared Nobel Prize in 1962, launched a new era of medicine, heralding today's astonishing advances in the genetic basis of disease. Max Perutz's story, wonderfully told by Georgina Ferry, brims with life; it has the zest of an adventure novel and is full of extraordinary characters. Max was demanding, passionate and driven but also humorous, compassionate and loving. Georgina Ferry's absorbing biography is a marvellous tribute to a great scientist.

This collection of essays from Nobel Laureate Max Perutz explores a wide range of scientific and personal topics with insight and lucidity. It includes lively anecdotes about key figures in 20th-century science.

Selected by his daughter Vivien, these letters chronicle Perutz's life through his own vivid, erudite, and humorous pen. With a spontaneity and directness no autobiography can match, this volume captures the hopes, roadblocks, and moments of elation throughout his 60-year quest to understand the molecular biology of hemoglobin.

In 1962, Maurice Wilkins, Francis Crick, and James Watson received the Nobel Prize, but it was Rosalind Franklin's data and photographs of DNA that led to their discovery. Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

The story of how humans and all living things came into existence is told in two widely believed versions: the Book of Genesis and Darwin's Origin of Species . It was the philosopher Karl Popper who presented us with a third story, no less important. His New Interpretation of Darwinism denies the creative power of blind chance and natural selection and establishes knowledge and activity of all living beings as the real driving forces of evolution. Thus, spiritual elements are back in the theory of evolution, and in Popper's view "the entire evolution is an adventure of the mind." In this book, Hans-Joachim Niemann establishes Karl Popper as an eminent philosopher of biology. In the first chapter, biographical details are unearthed concerning how Popper's biological interests were inspired by a biological meeting in the old windmill at Hunstanton in 1936. The second chapter focusses on the year 1986 when Popper, in several lectures, summarized the results of his life-long biological thinking. The most important of these, the Medawar Lecture given at the Royal Society London, was lost for a long time and is now printed in the Appendix. A new world view begins to emerge that is completely different from Creationism or Darwinism. Twenty years after Popper's death, the last chapter looks back on his biological thoughts in the light of new results of molecular biology. His attack at that time on long-lasting dogmas of evolutionary theory turned out to be largely justified. The new biology seems even well suited to support Popper's endeavour to overcome the gloomy aspects of Darwinism that have made organisms passive parts of a machinery of deadly competition. Neither blind chance nor natural selection are the creative forces of all life, but rather knowledge and activity. How they came into existence is still a secret and a worthwhile research programme.--

Portions of this book were first published in The Atlantic monthly.

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century. Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research. Scientists such as Stockwell are now developing methods to combat these complexities technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

A Best Book of the YearSeed Magazine • Granta Magazine • The Plain-DealerIn this fascinating and utterly engaging book, Carl Zimmer traces E. coli's pivotal role in the history of biology, from the discovery of DNA to the latest advances in biotechnology. He reveals the many surprising and alarming parallels between E. coli's life and our own. And he describes how E. coli changes in real time, revealing billions of years of history encoded within its genome. E. coli is also the most engineered species on Earth, and as scientists retool this microbe to produce life-saving drugs and clean fuel, they are discovering just how far the definition of life can be stretched.