Mechanisms Of Neuroinflammation
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Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury
Author | : Arthur Liesz,Christoph Kleinschnitz |
Publsiher | : Frontiers Media SA |
Total Pages | : 286 |
Release | : 2015-11-13 |
Genre | : Electronic book |
ISBN | : 9782889196913 |
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Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.
Neuroinflammation and its Resolution From Molecular Mechanisms to Therapeutic Perspectives
Author | : Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes |
Publsiher | : Frontiers Media SA |
Total Pages | : 282 |
Release | : 2020-07-14 |
Genre | : Electronic Book |
ISBN | : 9782889638543 |
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Mechanisms of Neuroinflammation
Author | : Gonzalo Emiliano Aranda Abreu |
Publsiher | : BoD – Books on Demand |
Total Pages | : 320 |
Release | : 2017-08-23 |
Genre | : Medical |
ISBN | : 9789535134510 |
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"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Mechanisms of Neuroinflammation
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 135 |
Release | : 19?? |
Genre | : Electronic Book |
ISBN | : 9535134523 |
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Neuroinflammation
Author | : Alireza Minagar |
Publsiher | : Elsevier |
Total Pages | : 540 |
Release | : 2010-12-17 |
Genre | : Science |
ISBN | : 0123849144 |
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Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities
Inflammation Fundamental Mechanisms
Author | : Ley Klaus |
Publsiher | : World Scientific |
Total Pages | : 372 |
Release | : 2018-03-13 |
Genre | : Medical |
ISBN | : 9789813109452 |
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Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation. Contents: TNF Superfamily in Inflammation (Marisol Veny, Richard Virgen-Slane and Carl F Ware) Complement as a Mediator of Inflammation (B Paul Morgan) Lipids and Inflammation (Valerie B O'Donnell, Robert C Murphy and Garret A FitzGerald) Reactive Oxygen Species (Ulla G Knaus) Leukocyte Adhesion (Klaus Ley and Zhichao Fan) Neutrophil Extracellular Traps (Tobias A Fuchs, Abdul Hakkim and Constantin F Urban) Sepsis (Jamison J Grailer, Matthew J Delano and Peter A Ward) Granulomatous Inflammation (Marc Hilhorst, Gene Hunder, Jörg Goronzy and Cornelia Weyand) Readership: Graduate students, medical doctors/ practitioners, researchers, pathologists and nutritionists in medicine and healthcare. Keywords: Cytokines;IL-1;TNF;Lipid Mediators;Bradykinin and Neuropeptides;Leukocyte Adhesion;Angiogenesis;Degranulation;Antimicrobial Peptides;Neutrophil Extracellular Traps (NETs);Pharmacologic Modulation of Inflammation;Sepsis;Complement;Oxygen Radicals;Reperfusion Injury;Resolution of Inflammation;Atherosclerosis;Granulomatous Inflammation;Inflammatory Bowel DiseaseReview: Key Features: Up-to-date resource Comprehensive review of the various facets of inflammation
Targeting Neuroinflammation in Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets and Neuropharmaceutical Developments
Author | : Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia |
Publsiher | : Frontiers Media SA |
Total Pages | : 396 |
Release | : 2022-01-20 |
Genre | : Science |
ISBN | : 9782889741076 |
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Neuroinflammation
Author | : Paul L. Wood |
Publsiher | : Springer Science & Business Media |
Total Pages | : 411 |
Release | : 2002-12-18 |
Genre | : Medical |
ISBN | : 9781592592975 |
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In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.