Medicinal Chemistry Of Bioactive Natural Products

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents. Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research. Enhanced by examples with updated research results, the discussion covers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and its analogs * The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer's disease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIV agents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations. Contents:Natural Products in Drug Discovery: Impacts and Opportunities — An Assessment (Goutam Brahmachari)Vascular Regulation by Small Peptides (Toshiro Matsui, Zhengquan Wang and Mitsuru Tanaka)Key Natural Products in Malaria Chemotherapy: From Quinine to Artemisinin and Beyond (Jean Fotie)Natural Product Inhibitors and Activators of Histone Deacetylases (Michael D Scott, Manas K Haldar and Sanku Mallik)Artemisinin: A Promise for the Development of Potent Anticancer Agents (Daniel L da Silva, Luzia V Modolo, Ilza M O Sousa, Rodney A F Rodrigues, Mary Ann Foglio and Ângelo de Fátima)Andrographolide: A Plant-Derived Natural Molecule of Pharmaceutical Promise (Goutam Brahmachari)Natural Products in Alzheimer's Disease: Impacts and Prospects (Shri Kant Mishra, Mark C Stahl and Parampreet Singh)Use of Multi-nutrient Functional Peptide Complex ≪GRINIZATION≫ for Treatment and Prevention of Viral Infections (Viktor Lozitsky, Alla Fedchuk, Irina Gomolyako, Ivan Chekman, Anatoliy Bulavka, Galyna Anokhina, Georgiy Donchenko, Sergiy Pozdnyakov, Xeniya Igrunova, Tetyana Grydina, Lidiya Socheslo, Liubov Mudryk, Nataliya Klochkova, Larysa Shytikova, Valentina Pushkina, Olga Golubovska, Vladimir Shestakov and Anatoliy Pechinka)Anti-Infective Flavonoids: An Overview (María José Abad, Luis Miguel Bedoya, Luis Apaza and Paulina Bermejo)Anti-Helicobacter Pylori Activities of Compounds of Natural Origin (Temitope O Lawal, Kapil K Soni, R C Saxena, Bolanle A Adeniyi and Gail B Mahady)Natural Bioactive Principles in the Treatment of Skin Diseases (Emmanuel C Ibezim)Anti-Diabetic Agents of Natural Origin: A Retrospective Account of Some Promising Chemotypes (Goutam Brahmachari)Fermentation Improvement of Processes Yielding Natural Products for Industry (Arnold L Demain and Sergio Sanchez)Plant Cell Culture and Transgenic Plants: The Goldmines for the Production of Compounds of Pharmacological Interest (Ana Paula de Faria, Ângelo de Fátima, Vagner A Benedito and Luzia V Modolo) Readership: Phytochemists; combinatorial chemists; pharmacologists; institutes for drug research (drug discovery and development); industrial research groups developing drugs from medicinal plants; pharmaceutical companies; manufacturers of herbal and ayurvedic medicines and cosmetic products; manufacturers of natural products; advanced and research students. Keywords:Bioactive Natural Products;Pharmacology;Pharmaceutics;Drug Discovery and Development;Medicinal ChemistryKey Features:Written by active researchers and leading experts in natural products chemistry on biologically active natural productsIncludes recent advances in the domain of discovery and development of new drugs in the pharmaceutical industryAn outstanding source of information with regard to the industrial application of natural products for medicinal purposes

Studies in Natural Products Chemistry, Volume 60 covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Studies in Natural Products Chemistry, Volume 48, provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development. The series covers all aspects of the science, along with the synthesis, testing, and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, the book presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry. Provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures Focuses on the chemistry of bioactive natural products and their exciting new applications in the pharmaceutical industry Presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products Contains contributions by leading authorities in the field

Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Studies in Natural Products Chemistry, Volume 54, covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores Offers an essential resource for researchers and engineers working in natural products and medicinal chemistry

This book covers the recent innovations relating to various bioactive natural products (such as alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, volatile oils, fixed oils, fats and waxes, proteins and peptides, vitamins, marine products, camptothecin, piperines, carvacrol, gedunin, GABA, ginsenosides) and their applications in the pharmaceutical fields related to academic, research and industry.