Membrane Separations In Biotechnology Second Edition

This text details the relationship between membrane technology and bioprocesses, discussing applications. This second edition refines and optimizes key features of the first edition - and features new illustrative case studies. The book examines advantages and disadvantages of using standard and new membrane technologies; analyzes a wide range of a

The Handbook of Membrane Separations: Chemical, Pharmaceutical, Food, and Biotechnological Applications, Second Edition provides detailed information on membrane separation technologies from an international team of experts. The handbook fills an important gap in the current literature by providing a comprehensive discussion of membrane application

The third edition of the Handbook of Membrane Separations: Chemical, Pharmaceutical, Food, and Biotechnological Applications provides a comprehensive discussion of membrane applications. Fully updated to include the latest advancements in membrane science and technology, it is a one-of-its-kind overview of the existing literature. This fully illustrated handbook is written by experts and professionals in membrane applications from around the world. Key Features: • Includes entirely new chapters on organic solvent-resistant nanofiltration, membrane condensers, membrane-reactors in hydrogen production, membrane materials for haemodialysis, and integrated membrane distillation • Covers the full spectrum of membrane technology and its advancements • Explores membrane applications in a range of fields, from biotechnological and food processing to industrial waste management and environmental engineering This book will appeal to both newcomers to membrane science as well as engineers and scientists looking to expand their knowledge on upcoming advancements in the field.

The plan of this book is to present the relevant thermodynamic features of fluid mixtures in contact with semipermeable barriers, then to apply this information in deriving the design requirements of individual membrane separation processes. The membranes, by this approach, are introduced by way of the mass transport and selectivity demands which they are to meet. This book gives a survey, in systematic order, of the terms and concepts by which barrier separations operate.

Centrifugal Separations in Biotechnology, Second Edition, is the only book on the market devoted to centrifugal separation in biotechnology. Key topics covered include a full introduction to centrifugation, sedimentation and separation; detailed coverage of centrifuge types, including batch and semi-batch centrifuges, disk-stack and tubular decanter centrifuges; methods for increasing solids concentration; laboratory and pilot testing of centrifuges; selection and sizing centrifuges; scale-up of equipment, performance prediction and analysis of test results using numerical simulation. Centrifugal Separations in Biotechnology, Second Edition, provides guidance on troubleshooting and optimizing centrifuges, and then goes on to explore the commercial applications of centrifuges in biotechnology. It gives detailed process information and data to assist in the development of particular processes from existing systems. It is of value to professionals in the chemical, bioprocess, and biotech sectors, and all those concerned with bioseparation, bioprocessing, unit-operations and process engineering. Provides a comprehensive guide to centrifuges, their optimal development, and their operation in the biotechnology industry Updated throughout based on developments in industrial applications and advances in our understanding of centrifugal separations in biotechnology Discusses applications for the separation of proteins, DNA, mitochondria, ribosomes, lysosomes and other cellular elements Includes new sections on use of optimal polymer dosage in waste treatment, new centrifuge designs for applications in algae processing, biopharma, and more

This concise and systematically organized text, now in its second edition, gives a clear insight into various membrane separation processes. It covers the fundamentals as well as the recent developments of different processes along with their industrial applications and the products. It includes the basic principles, operating parameters, membrane hardware, flux equation, transport mechanism, and applications of membrane-based technologies. Membrane separation processes are largely rate-controlled separations which require rate analysis for complete understanding. Moreover, a higher level of mathematical analysis, along with the understanding of mass transfer, is also required. These are amply treated in different chapters of the book to make the students comprehend the membrane separation principles with ease. This textbook is primarily designed for undergraduate students of chemical engineering, biochemical engineering and biotechnology for the course in membrane separation processes. Besides, the book will also be useful to process engineers and researchers. KEY FEATURES • Provides sufficient number of examples of industrial applications related to chemical, metallurgical, biochemical and food processing industries. • Focuses on important biomedical applications of membrane-based technologies such as blood oxygenator, controlled drug delivery, plasmapheresis, and bioartificial organs. • Includes chapter-end short questions and problems to test students’ comprehension of the subject. NEW TO THIS EDITION • A new section on membrane cleaning is included. Membrane fabrication methods are supplemented with additional information (Chapter 2). • Additional information on silt density index, forward osmosis and sea water desalination (Chapter 3). • Physicochemical parameters affecting nanofiltration, determination of various resistances using resistance in series model and few more industrial applications with additional short questions (Chapter 4). • Membrane cross-linking methods used in pervaporation, factors affecting pervaporation and few more applications (Chapter 9). • Membrane distillation, membrane reactor with different modules, types of membranes and reactions for membrane reactor (Chapter 13).

The second edition of Comprehensive Biotechnology, Six Volume Set continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field

Process Validation in Manufacturing of Biopharmaceuticals, Third Edition delves into the key aspects and current practices of process validation. It includes discussion on the final version of the FDA 2011 Guidance for Industry on Process Validation Principles and Practices, commonly referred to as the Process Validation Guidance or PVG, issued in final form on January 24, 2011. The book also provides guidelines and current practices, as well as industrial case studies illustrating the different approaches that can be taken for successful validation of biopharmaceutical processes. Case studies include Process validation for membrane chromatography Leveraging multivariate analysis tools to qualify scale-down models A matrix approach for process validation of a multivalent bacterial vaccine Purification validation for a therapeutic monoclonal antibody expressed and secreted by Chinese Hamster Ovary (CHO) cells Viral clearance validation studies for a product produced in a human cell line A much-needed resource, this book presents process characterization techniques for scaling down unit operations in biopharmaceutical manufacturing, including chromatography, chemical modification reactions, ultrafiltration, and microfiltration. It also provides practical methods to test raw materials and in-process samples. Stressing the importance of taking a risk-based approach towards computerized system compliance, this book will help you and your team ascertain process validation is carried out and exceeds expectations.