Micro And Nanofabrication Using Self Assembled Biological Nanostructures

Self-assembled nanostructures based on peptides and proteins have been investigated and presented as biomaterials with an impressive potential for a broad range of applications such as microfabrication, biosensing platforms, drug delivery systems, bioelectronics and tissue reparation. Through self-assembly peptides can give rise to a range of well-defined nanostructures such as nanotubes, nanofibers, nanoparticles, nanotapes, gels and nanorods. However, there are challenges when trying to integrate these biological nanostructures in the development of sensing devices or drug-delivery systems – challenges such as controlling the size during synthesis, the stability in liquid environments and manipulation. In "Micro and Nanofabrication Using Self-assembled Biological Nanostructures" the options and challenges when using self-assembled peptide nanostructures in micro and nanofabrication are discussed. The publication covers different ways to manipulate, deposit and immobilize on specific locations these biological nanostructures in order to use them in the fabrication of new structures or as part of biosensing platforms. Examples where researchers used biological nanostructures for those types of applications are provided. Finally, future applications are discussed as well as parameters to accelerate and expand the use of these biological building blocks in nano- and micro-fabrication processes by taking advantage of their impressive properties such as low-cost and short synthesis time.

The self-organization of bionanostructures into well-defined functional machineries found in nature has been a priceless source of ideas for researchers. The molecules of life, proteins, DNA, RNA, etc., as well as the structures and forms that these molecules assume serve as rich sources of ideas for scientists or engineers who are interested in developing bio-inspired materials for innovations in biomedical fields. In nature, molecular self-assembly is a process by which complex three-dimensional structures with well-defined functions are constructed, starting from simple building blocks such as proteins and peptides. This book introduces readers to the theory and mechanisms of peptide self-assembly processes. The authors present the more common peptide self-assembled building blocks and discuss how researchers from different fields can apply self-assembling principles to bionanotechnology applications. The advantages and challenges are mentioned together with examples that reflect the state of the art of the use of self-assembled peptide building blocks in nanotechnology.

Nanomedicine: Technologies and Applications, Second Edition provides an important review of this exciting technology and its growing range of applications. In this new edition, all chapters are thoroughly updated and revised, with new content on antibacterial technologies and green nanomedicine. Sections introduce the material, cover their properties, review nanomedicine for therapeutics, imaging and soft tissue engineering, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Other sections cover bone and cartilage tissue engineering, nanostructured particles for antibacterial purposes, advances in green nanomedicine, and using natural nanomedicine to fight disease. This book is an indispensable guide for all those involved in the research, development and application of this exciting technology, whilst also providing a comprehensive introduction for students and academics interested in this field. Provides an important review of nanomedicine technology and its growing range of applications Discusses key nanomedicine materials and their properties, including nanocrystalline metals, alloys and nanoporous gold and hydroxyapatite coatings Features updated content in all parts, as well as a number of new chapters on antibacterial nanomedicine and green nanomedicine

Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.

Fiber and Textile Engineering in Drug Delivery Systems explains how innovative textile processing methods including rotary spinning, microfluidics, wet spinning and electrospinning can be used to produce novel drug delivery solutions. This topical book provides detailed descriptions of how to produce such new materials for this purpose, with foundational content to help readers from a range of backgrounds understand the context of material selection and design decisions. Emphasis is given to the engineering side of the manufacturing of the textile and its role in drug delivery, but this also acts as a guide to pharmaceutical applications of textile fibers for materials scientists. Drug delivery research is rapidly expanding and experimenting with new materials to drive improved clinical outcomes as the efficacy of the therapeutic molecule is highly dependent on the right choice of carrier system. Recently, fiber based carriers at both nano and micro scales are gaining interest in the scientific community due to ease of manufacturing, high surface area to volume ratio, desirable drug release kinetics and high mechanical strength. Describes methods for material selection and design for drug delivery systems Provides case studies to explain how these techniques can be applied successfully Covers the regulatory and legal aspects of the use of the textiles and fibers in drug delivery

Nanobiomaterials Science, Development and Evaluation examines the practical aspects of producing nanostructured biomaterials for a range of applications. With a strong focus on materials, such as metals, ceramics, polymers, and composites, the book also examines nanostructured coatings and toxicology aspects. Chapters in Part One look at materials classes and their synthesis with information on all major material groups. Part Two focuses on nanostructured coatings and practical aspects associated with the use of nanobiomaterials in vivo. This book brings together the work of international contributors who are actively engaged on the forefront of research in their respective disciplines, and is a valuable resource for materials scientists in academia, industry, and all those who wish to broaden their knowledge in the allied field. Focuses on the synthesis and evaluation techniques for a range of nanobiomaterials Examines nanostructured inorganic coatings for biomaterials Discusses issues related to the toxicology of nanobiomaterials Presents the practical aspects of nanobiomaterials

Nanoelectronics: Physics, Materials and Devices addresses the concepts involved in the exploration of research on nanoscale electronics and photonic devices and their application in next-generation integrated circuits (ICs). The book presents a detailed discussion on the field of nanoscale electronic and photonic devices, as well as the most recent techniques for the modeling and simulation of these devices. It provides an in-depth analysis of theoretical frameworks, the fundamental physics underlying device operation, computational modeling, simulation methods, and circuit applications of nanoscale devices. The purpose of this book is to provide a desirable balance between basic background and concepts to improve device performance. In this book, both qualitative and quantitative approaches are considered to analyze and explore the contributions made by various researchers actively engaged in nanoscale device research. The book's main motivation is to help solve the challenges of analyzing and exploring the electrical behaviors of contemporary nanoscale device technologies. It purposefully builds the principles of nano electronic devices gradually, invigorating those of micro electronic devices. Addresses the conceptual, architectural, and design challenges faced by emerging nanoscale devices as a replacement of conventional MOSFET Serves as a guide to researchers by suggesting research directions and potential applications Explains the use of Technology Computer-Aided Design software (TCAD) to produce numerical simulations of nanoscale devices

Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine discusses recent advances in science and technology using nanoscale units that show the novel concept of combining nanotechnology with various research disciplines within both the biomedical and medicine fields. Self-assembly of molecules, macromolecules, and polymers is a fascinating strategy for the construction of various desired nanofabrication in chemistry, biology, and medicine for advanced applications. It has a number of advantages: (1) It is involving atomic-level modification of molecular structure using bond formation advanced techniques of synthetic chemistry. (2) It draws from the enormous wealth of examples in biology for the development of complex, functional structures. (3) It can incorporate biological structures directly as components in the final systems. (4) It requires that the target self-assembled structures be thermodynamically most stable with relatively defect-free and self-healing. In this book, we cover the various emerging self-assembled nanostructured objects including molecular machines, nano-cars molecular rotors, nanoparticles, nanosheets, nanotubes, nanowires, nano-flakes, nano-cubes, nano-disks, nanorings, DNA origami, transmembrane channels, and vesicles. These self-assembled materials are used for sensing, drug delivery, molecular recognition, tissue engineering energy generation, and molecular tuning. Provides a basic understanding of how to design, and implement various self-assembled nanobiomaterials Covers principles implemented in the constructions of novel nanostructured materials Offers many applications of self-assemblies in fluorescent biological labels, drug and gene delivery, bio-detection of pathogens, detection of proteins, probing of DNA structure, tissue engineering, and many more