Microbial Bioprocesses

Microbial processes are involved in food, chemical, pharmaceutical, cosmetics, energy, and new-material industries. Over the past 2 decades, new or more efficient industrial processes involving microorganisms have been launched, yielding purer, less expensive products or substances not available using classical chemical methods. Microbial Bioprocesses aims to give an overview of established and successful processes and discusses the trends and perspectives in industrial microbiology which, along with tremendous progress in genetic and metabolic engineering in recent years, are once again becoming an area of innovation and emerging technologies. Microbial Bioprocesses covers the unique areas like microbial volatiles (MVOCs), microbial bioinoculant development, bacterial nanocelluloses production, and processes for remediation by fungi and actinobacteria. Provides an innovative description of emerging bioprocesses for biotechnological gains Provides a broad cross section of microbial bioprocess that covers several sustainability applications Gives general insights about how microorganisms can be utilized in production of various chemicals

Microbes are widely used in large-scale industrial processes due to their versatility, easy growing cultivation, kinetic potential, and the ability to generate metabolites with a wide range of potential applications to various commercial sectors, such as the food, pharmaceutical and cosmetic industries, in addition to the potential for agriculture, biomedical, and several others. Among the metabolites of greatest commercial interest, and many obtained on an industrial scale, the wide range of enzymes, biofuels, organic acids, amino acids, vitamins, biopolymers, and many other classes of metabolites. This book is intended for Bioengineers, Biologist, Biochemist, Biotechnologists, microbiologist, food technologist, enzymologist, and related Professionals/ researchers. Explores recent advances in the valorization of agri-food waste Provides technical concepts on the production of various bio-products of commercial interest Discusses the main process conditions to overcome the difficulties of using waste as alternative raw materials Introduces technical-economic details on the advantages and disadvantages of exploring the waste recovery chain Explores the main technological advances in the recovery of residues in functional products

This review series covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. Electronic version available at http://link.springer.de/series/abe/

This book argues that the sustainable management of resources requires a systematic approach that primarily involves the integration of green innovative biotechnological strategies and eco-engineering. It discusses how microbial community intelligence can be used for waste management and bio-remediation and explains how biological processes can be optimized by integrating genomics tools to provide perspectives on sustainable development. The book describes the application of modern molecular techniques such as fluorescence in situ hybridization (FISH), highly sensitive catalyzed reporter deposition (CARD)-FISH, in situ DNA-hybridization chain reaction (HCR) and methods for detecting mRNA and/or functional genes to optimize bioprocessess. These techniques, supplemented with metagenomic analysis, reveal that a large proportion of micro-organisms still remain to be identified and also that they play a vital role in establishing bioprocesses.

Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy, by Bernhard Sonnleitner Automatic Control of Bioprocesses, by Marc Stanke, Bernd Hitzmann An Advanced Monitoring Platform for Rational Design of Recombinant Processes, by G. Striedner, K. Bayer Modelling Approaches for Bio-Manufacturing Operations, by Sunil Chhatre Extreme Scale-Down Approaches for Rapid Chromatography Column Design and Scale-Up During Bioprocess Development, by Sunil Chhatre Applying Mechanistic Models in Bioprocess Development, by Rita Lencastre Fernandes, Vijaya Krishna Bodla, Magnus Carlquist, Anna-Lena Heins, Anna Eliasson Lantz, Gürkan Sin and Krist V. Gernaey Multivariate Data Analysis for Advancing the Interpretation of Bioprocess Measurement and Monitoring Data, by Jarka Glassey Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks, by Inês A. Isidro, Ana R. Ferreira, João J. Clemente, António E. Cunha, João M. L. Dias, Rui Oliveira Knowledge Management and Process Monitoring of Pharmaceutical Processes in the Quality by Design Paradigm, by Anurag S Rathore, Anshuman Bansal, Jaspinder Hans The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses, by Ian Marison, Siobhán Hennessy, Róisín Foley, Moira Schuler, Senthilkumar Sivaprakasam, Brian Freeland

Bioprocessing has been used for a long time in the production of food. In fact, as early as 3,500 B.C., Sumerian brewers were using bioprocessing to create a popular beverage many drinkers still enjoy today. Bioprocessing, as the name suggests, uses living organisms and their components in the creation of new products. Bioprocessing is often used to manufacture pharmaceuticals, sustainable materials, alternative fuels, and even many of the foods we enjoy. Biotechnology as applied to food processing in most developing countries makes use of microbial inoculants to enhance properties such as the taste, aroma, shelf-life, texture and nutritional value of foods. The process whereby micro-organisms and their enzymes bring about these desirable changes in food materials is known as fermentation. Fermentation processing is also widely applied in the production of microbial cultures, enzymes, flavours, fragrances, food additives and a range of other high value-added products. These high value products are increasingly produced in more technologically advanced developing countries for use in their food and non-food processing applications. Many of these high value products are also imported by developing countries for use in their food-processing applications. Food, food-biocatalists and bioprocessing industries face great challenges in order to develop and establish systems to develop high quality, safety foods, as well as feeds and other industrial goods, environmentally acceptable and in a sustainable way. The text is supported by numerous clear informative diagrams. The book would be highly useful to the postgraduate students and researchers of applied biology, biotechnology, microbiology and biochemical engineering.

Basic Biotechniques for Bioprocess and Bioentrepreneurship deals with the entire field of industrial biotechnology, starting from the basic laboratory techniques to scale-up, process development, demonstration, and finally its commercialization. The book compiles currently scattered materials on this topic and updates this information based on practical experience and requirements. The book will be an ideal source for new entrepreneurs who wish to start their own commercial units. Offers guidance for readers/researchers/start-ups/entrepreneurs on how to develop new microbiological and biotechnical processes Focuses on basic knowledge and possible solutions to the practical difficulties at all levels in one place through understanding of basic techniques in lab, during bioprocess development, commercialization, technology transfer, marketing, and others which is presently not available in the field Provides multifaceted coverage, with industry insights from experienced practitioners and leaders in the field Gives possible best solutions to the practical difficulties at all levels, i.e. lab, scaleup, and commercial stage Addresses ethical and other regulatory issues

Microorganisms play an important role in life on Earth and can adapt and survive in harsh and changing environments. Their aptitude to thrive under hostile conditions is reflected by their survival and activity in some of the most extreme environments on Earth and their presence and growth in low earth orbit and outer space. Spaceflight and the space environment have a unique set of stressors compared to Earth (microgravity, galactic cosmic radiation, solar UV radiation, space vacuum, thermal extremes) that microbes are exposed to, but how they adapt and respond is still poorly understood. Studies to date, though, have shown that these responses can range from being beneficial for human exploration to negatively impact long duration missions. Hence, investigating the reaction of microorganisms to space conditions, the alterations in their physiology and virulence, not only helps shed light on the molecular basis of tolerance, but has implications for both space exploration and astrobiological missions.