Microbial Interactions At Nanobiotechnology Interfaces

MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.

Nanomaterials are becoming ubiquitous; microbes similarly are everywhere. This book focuses on various ways the diverse nanomaterials interact with microbial communities and implications of such interactions. Both toxicity and beneficial effects of nanomaterial-microbe interactions have been covered. This includes areas such as fate and bioavailability of nanomaterials in environments, microbial synthesis of nanomaterials and antimicrobial action of nanomaterials. Fairly comprehensive but with narrow focus, the book provides useful insights into these interactions which need to be factored in while designing nanoscience based new technologies.

MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.

Advances in Virus Research serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Virus Research serials Updated release includes the latest information on Microbes at bio/nano interfaces

This book discusses the unique interactions of nanoparticles with various biomolecules under different environmental conditions. It describes the consequences of these interactions on other biological aspects like flora and fauna of the niche, cell proliferation, etc. The book provides information about the novel and eco-friendly nanoparticle synthesis methods, such as continuous synthesis of nanoparticles using microbial cells. Additionally, the book discusses nanoparticles' potential impact in different areas of biological sciences like food, medicine, agriculture, and the environment. Due to their advanced physicochemical properties, nanoparticles have revolutionized biomedical and pharmaceutical sciences. Inside the biological milieu, nanoparticles interact with different moieties to adopt stable shape, size, and surface functionalities and form nano-biomolecular complexes. The interaction pattern at the interface form complexes determines the fate of interacting biomolecules and nanoparticles inside the biological system. Understanding the interaction pattern at the nano-bio interface is crucial for the safe use of nanoparticles in natural sciences. This book rightly addresses all questions about the interaction and the ensuing structure and function of these nano-biomolecular complexes. This book caters to students and researchers in the area of biotechnology, microbiology, and pharmaceutical sciences.

Although interactions between nanoparticles and microorganisms in the environment are unavoidable and commonplace, it is still not clear what potential effects they may have. Metallic Nanocrystallites and their Interface with Microbial Systems not only illustrates how microbes and these particular nanoparticles interact but also it describes the consequences of these interactions. This brief discusses the impact of gold, silver, zinc oxide, and cerium oxide nanoparticles on the growth and viability of both Gram-negative and Gram-positive bacterium. Moreover, it analyses the relationship between bacterial growth inhibition, reactive oxygen species generation, the regulation of transcriptional stress genomes, and the toxicity of these materials. Finally, it reviews the specific metallic nanomaterials and highlights their modes of synthesis, reactivity at surfaces, and the importance of assay procedures in determining their toxicity levels. Various microscopy techniques used to determine their mechanisms of action are also presented. Metallic Nanocrystallites and their Interface with Microbial Systems will be a valuable source to the scientific and industrial community as well as to students and researchers in microbiology, biotechnology, nanotechnology, toxicology, materials science, biomedical engineering, cell and molecular biology.

Microbial Nanobionics: Volume 2, Basic Research Applications continues the important discussion of microbial nanoparticle synthesis with a focus on the mechanistic approach of biosynthesis towards nanobionics. This volume also explores the toxicity of nanomaterials in microbes and their effect on human health and the environment. Special Emphasis is given to the use of polymeric nanomaterials in smart packing for the food industry and agricultural sector. The future of nanomaterials for detection of soil microbes and their interactions and tools for environmental remedies is also comprehensively covered. The rich biodiversity of microbes make them excellent candidates for potential nanoparticle synthesis biofactories. Through a better understanding of the biochemical and molecular mechanisms of the microbial biosynthesis of metal nanoparticles, the rate of synthesis can be better developed and the monodispersity of the product can be enhanced. The characteristics of nanoparticles can be controlled via optimization of important parameters, such as temperature, pH, concentration and pressure, which regulate microbe growth conditions and cellular and enzymatic activities. Large scale microbial synthesis of nanoparticles is a sustainable method due to the non-hazardous, non-toxic and economical nature of these processes. The applications of microbial synthesis of nanoparticles are wide and varied, spanning the industrial, biomedical and environmental fields. Biomedical applications include improved and more targeted antimicrobials, biosensing, imaging and drug delivery. In the environmental fields, nanoparticles are used for bioremediation of diverse contaminants, water treatment, catalysis and production of clean energy. With the expected growth of microbial nanotechnology, this volume will serve as a comprehensive and timely reference.

In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.