Micromixers

Introduction -- Fundamentals of Mass Transport in Micro Scale -- Fabrication Technologies -- Micromixers Based on Molecular Diffusion -- Micromixers Based on Chaotic Advection -- Active Micromixers -- Characterization Techniques -- Applications of Micromixers.

This book is a printed edition of the Special Issue " Passive Micromixers" that was published in Micromachines

This book illustrates the computational framework based on knowledge of flow and mass transfer together with optimization techniques to solve problems relevant to micromixing technology. The authors provide a detailed analysis of the different numerical techniques applied to the design of micromixers. Flow and mixing analysis is based on both the Eulerian and Lagrangian approaches; relative advantages and disadvantages of the two methods and suitability to different types of mixing problems are analysed. The book also discusses the various facets of numerical schemes subjected to discretization errors and computational grid requirements. Since a large number of studies are based on commercial computational fluid dynamics (CFD) packages, relevant details of these packages to the mixing problem using them are presented. Numerical optimization techniques coupled with CFD analysis of flow and mixing have proved to be an important tool for micromixers design, and therefore, are an important part of the book. These techniques are presented briefly, and focus is on surrogate modeling and optimization applied to design of micromixers.

The ability to mix minute quantities of fluids is critical in a range of recent and emerging techniques in engineering, chemistry and life sciences, with applications as diverse as inkjet printing, pharmaceutical manufacturing, specialty and hazardous chemical manufacturing, DNA analysis and disease diagnosis. The multidisciplinary nature of this field – intersecting engineering, physics, chemistry, biology, microtechnology and biotechnology – means that the community of engineers and scientists now engaged in developing microfluidic devices has entered the field from a variety of different backgrounds. Micromixers is uniquely comprehensive, in that it deals not only with the problems that are directly related to fluidics as a discipline (aspects such as mass transport, molecular diffusion, electrokinetic phenomena, flow instabilities, etc.) but also with the practical issues of fabricating micomixers and building them into microsystems and lab-on-chip assemblies.With practical applications to the design of systems vital in modern communications, medicine and industry this book has already established itself as a key reference in an emerging and important field. The 2e includes coverage of a broader range of fabrication techniques, additional examples of fully realized devices for each type of micromixer and a substantially extended section on industrial applications, including recent and emerging applications. Introduces the design and applications of micromixers for a broad audience across chemical engineering, electronics and the life sciences, and applications as diverse as lab-on-a-chip, ink jet printing, pharmaceutical manufacturing and DNA analysis Helps engineers and scientists to unlock the potential of micromixers by explaining both the scientific (microfluidics) aspects and the engineering involved in building and using successful microscale systems and devices with micromixers The author's applied approach combines experience-based discussion of the challenges and pitfalls of using micromixers, with proposals for how to overcome them

This unique volume presents leading-edge microfluidics methods used to handle, manipulate, and analyze cells, particles, and biological components (e.g., proteins and DNA) for microdiagnostics. The authors offer clear and detailed guidance on microfabrication techniques utilized to create microfluidic devices and on-chip flow control and mixing Microsystems, protein and DNA handling devices for electrophoretic and isoelectric separations in microchromatography columns, microfluidic manipulations of droplets via electrowetting and particles via dielectrophoresis for separations and chemical reactions, integrated optical characterization of microfluidic devices, controlling chemical gradients within devices, microimmunoassay diagnostics, multiphase microfluidics used in droplet formation for controlled chemical reactions, particle separation and analysis in Micro-FACS systems, flow characterization techniques in microfluidic devices and patterning and utilizing cytoskeletal filaments and cellular transport protein within microstructures.

This three-volume handbook provides an overview of the key aspects of micro process engineering. Volume 1 covers the fundamentals, operations and catalysts, volume 2 examines devices, reactions and applications, with volume 3 rounding off the trilogy with system, process and plant engineering. Fluid dynamics, mixing, heat/mass transfer, purification and separation microstructured devices and microstructured reactors are explained in the first volume. Volume 2 segments microreactor design, fabrication and assembly, bulk and fine chemistry, polymerisation, fuel processing and functional materials into understandable parts. The final volume of the handbook addresses microreactor systems design and scale-up, sensing, analysis and control, chemical process engineering, economic and eco-efficiency analyses as well as microreactor plant case studies in one book. Together, this 3-volume handbook explains the science behind micro process engineering to the scale-up and their real life industrial applications.

Flow Control Methods and Devices in Micrometer Scale Channels, by Shuichi Shoji and Kentaro Kawai. Micromixing Within Microfluidic Devices, by Lorenzo Capretto, Wei Cheng, Martyn Hill and Xunli Zhang. Basic Technologies for Droplet Microfluidics, by Shaojiang Zeng, Xin Liu, Hua Xie and Bingcheng Lin. Electrorheological Fluid and Its Applications in Microfluidics, by Limu Wang, Xiuqing Gong and Weijia Wen. Biosensors in Microfluidic Chips, by Jongmin Noh, Hee Chan Kim and Taek Dong Chung. A Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics, by Satyajyoti Senapati, Sagnik Basuray, Zdenek Slouka, Li-Jing Cheng and Hsueh-Chia Chang. Optical Detection Systems on Microfluidic Chips, by Hongwei Gai, Yongjun Li and Edward S. Yeung. Integrated Microfluidic Systems for DNA Analysis, by Samuel K. Njoroge, Hui-Wen Chen, Małgorzata A. Witek and Steven A. Soper. Integrated Multifunctional Microfluidics for Automated Proteome Analyses, by John K. Osiri, Hamed Shadpour, Małgorzata A. Witek and Steven A. Soper. Cells in Microfluidics, by Chi Zhang and Danny van Noort. Microfluidic Platform for the Study of Caenorhabditis elegans,by Weiwei Shi, Hui Wen, Bingcheng Lin and Jianhua Qin.

This book presents select proceedings of the 2nd International Conference on Industrial and Manufacturing Systems (CIMS 2021) and discusses the applications of soft computing, modelling and optimization practices in industrial and manufacturing systems. Various topics covered in this book include advanced machining methods and performances, industrial operations, processing with hybrid manufacturing techniques, fabrication and developments in micro-machining and its applications, practical issues in supply chain, micro-structure analysis, additive manufacturing processes, reliability and system analysis, material science and metallurgical behaviour analysis, product design and development, etc. The book will be a valuable reference for beginners, researchers, and professionals interested in the modelling, optimization and soft computing related aspects of industrial and production engineering and its allied domains.