Molecular Nutrition And Mitochondria

Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction. Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food. Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction. Describes the fundamentals of mitochondria physiology and considers the methods used to evaluate mitochondrial imbalance in clinical practice Provides broad biochemical and metabolic background on nutritional deficits found in mitochondrial dysfunction Explores the prevention and treatment of various inherited and acquired disorders associated with mitochondrial dysfunction Discusses the link between the dosage for each nutrient (nutritional vs. pharmacological) and the clinical effect Features a dedicated section on whole-diet interventions and mitochondrial function

Molecular Nutrition: Vitamins presents the nutritional and molecular aspects of vitamins with a specific focus on vitamins A, B1 (thiamine), B2 (riboflavin), B# (niacin), B5 (pantothenic acid), B6, (pyridoxine), B7 (biotin), B9 (folate), B12 (colbamin), C, D, E, and K. As part of the Molecular Nutrition series, this book discusses introductory aspects and general coverage of vitamins and nutrition, the molecular biology of the cell, including signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis. Final sections cover genetic machinery and its function, transcriptional processes, homeostasis genes, cancer, gene expression, mutations, and more. Emerging fields of molecular biology and important discoveries related to diet and nutritional health are also covered, rounding out the book. Summarizes molecular nutrition in health as related to vitamins Includes material on signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis Presents transcriptional processes, homeostasis genes, cancer, gene expression, mutations, the sodium-dependent multivitamin transporter, p53, p21, microRNAs, one carbon metabolism, nucleic acids, DNA methylation and polymorphisms Addresses emerging fields of molecular biology and presents important discoveries related to diet and nutritional health Covers Vitamins A, B, C, D, E, and K Discusses their impact on health relating to cancer, diabetes, arthritis, and aging Includes key facts, a mini dictionary of terms, and summary points

The Molecular Nutrition of Amino Acids and Proteins provides an in-depth look at the involvement and role of amino acids and proteins in molecular nutrition. Editor Dominique Dardevet has assembled a collection of chapters written by leading researchers and top professors that provide the reader with a comprehensive understanding of amino acids and proteins. The book provides an introduction to the fundamentals of amino acids and proteins as well as the composition of food. It then delves into the molecular biology of the cell and genetic machinery and its function. The Molecular Nutrition of Amino Acids and Proteins also features reference guides for terms and bullet-point summaries, making it readily accessible to novices while still providing the most up-to-date and detailed information that experienced researchers need. Provides a gentle introduction to the subject by first addressing nutritional information and then building in molecular aspects, clearly establishing fundamental information for the reader Facilitates reader comprehension by including succinct summary points in each chapter Contains a glossary of definitions that allows readers to easily reference terms Provides both a deep and broad understanding of the subject by containing overviews as well as detail-focused chapters

What are the functions of mitochondria in the human body? Why might they stop working properly and what can happen as a result? How can personalized nutrition help to optimize mitochondrial function and prevent or address chronic conditions? This innovative book explores the incredibly complex biochemical roles of mitochondria in health and disease. When healthy, mitochondria provide us with ninety percent of our body's energy. When unhealthy, this can lead to many chronic and degenerative conditions including cancer and Alzheimer's disease. This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore within the model of personalized nutrition.

Molecular nutrition (the study of interactions between nutrients and various intracellular and extracellular molecules) is one of the most rapidly developing fields in nutritional science. Ultimately, molecular nutrition research will reveal how nutrients may affect fundamental processes such as DNA repair, cell proliferation, and apoptosis. This book is the only single complete volume available reviewing the field of molecular nutrition. It contains contributions from leading international experts, and reviews the most important and latest research from various areas of molecular nutrition.

Human beings produce energy according to quantum principles. Therefore, human beings need to eat what is consistent with quantum biology. Human beings must eat quantum.This book will help you to eat in a way that is appropriate for the biology of our mitochondria-our source of life, our energy engines. The thousands of mitochondria in each of our cells are there only for us to produce energy. Altogether they number trillions, and we are dependent on them.- Even a strand of our hair cannot grow without the energy from mitochondria. - Our aging cells cannot be renewed without the energy produced by mitochondria.- We will not recover from diseases if mitochondria do not produce energy. We are dependent on that energy for something as simple as blinking an eye and something as vital as our immune system intercepting a cancer cell. All our life functions are dependent on that energy. We must secure that energy. And what's more, we must do this for every second of twenty-four hours a day. We must do whatever it takes for our mitochondria to produce that energy for us. We must give whatever source of energy they choose as fuel to these energy engines. Otherwise, we shall die. Our afflictions in illness and cures in treatment are the same for all of us: choosing the most appropriate fuel for our mitochondrial engine, so that it may produce the best energy. That is our fundamental task. That is our prime concern. The best fuel is the most appropriate one (nothing more) for our mitochondria's biology, our mitochondria's quantum biology. Classical biology is now inadequate in explaining the complex energy production in mitochondria. The new biology is quantum biology.If we want to stay alive for many years and live a healthy life, we cannot go against the unequivocal principles of biology. We receive energy that supplies our vitality according to quantum biological principles of mitochondria. In other words, we must abide by the rules of quantum biology. The medicine of the future will merely be to prevent initial damage. In the future, physicians will not be diagnosing diseases.Consequently, there will no longer be such a thing as curing diseases. Medicine, biophysics, biomedicine, quantum physics, and electronics will be intertwined, and the system faults will be dealt with at micro and molecular levels. There will be a greater need for quantum biologists than for surgeons.These are not exaggerations, they just need broader thinking. Since we accept that we are biological creatures, we must stop ignoring the biology of our smallest units-the cells, and the organelles inside them. The secret that makes the human being a special living species is hidden in the system inside these cells. The cells' own inner processes, energy production, intercellular communication, the cell systems' functioning as a whole, the cells being synchronized with the earth, sun, and universe occur entirely according to the rules of quantum biology. These are subatomic events that seem strange to us.Subatomic little particles (not just electrons and protons but quarks, tachyons, etc.) and information about their effects on health and vitality will in time be a source of amazement.Throughout this book, I have only attempted to clarify matters at the cell and mitochondria levels-the deepest points to which we can go down. If we can understand even this much, we can establish the link between our health and getting ill.

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition