Molecular Theory Of Water And Aqueous Solutions Part I Ii

The aim of this book is to explain the unusual properties of both pure liquid water and simple aqueous solutions, in terms of the properties of single molecules and interactions among small numbers of water molecules. It is mostly the result of the author's own research spanning over 40 years in the field of aqueous solutions. An understanding of the properties of liquid water is a prelude to the understanding of the role of water in biological systems and for the evolvement of life.The book is targeted at anyone who is interested in the outstanding properties of water and its role in biological systems. It is addressed to both students and researchers in chemistry, physics and biology.

This book starts out by presenting the evidence for the importance of hydrophilic interactions in biochemical processes and then goes on to describe the applications of the hydrophilic interactions in these processes, specifically protein folding, protein association, self assembly and molecular recognition. In this volume it is shown that the new paradigm, based on the hydrophilic effect, brings us as close as one can hope to the solutions of the protein folding problem, as well as the problem of self assembly and molecular recognition. In addition, the new paradigm also provides an explanation of the high solubility of globular proteins. The change in the paradigm is shown symbolically in the cover design of this book. This book is also available as a set with Molecular Theory of Water and Aqueous Solutions Part 1: Understanding Water.

"The aim of this book is to explain the unusual properties of both pure liquid water and simple aqueous solutions, in terms of the properties of single molecules and interactions among small numbers of water molecules. It is mostly the result of the author's own research spanning over 40 years in the field of aqueous solutions."--Jacket.

The molecular theory of water and aqueous solutions has only recently emerged as a new entity of research, although its roots may be found in age-old works. The purpose of this book is to present the molecular theory of aqueous fluids based on the framework of the general theory of liquids. The style of the book is introductory in character, but the reader is presumed to be familiar with the basic properties of water [for instance, the topics reviewed by Eisenberg and Kauzmann (1969)] and the elements of classical thermodynamics and statistical mechanics [e.g., Denbigh (1966), Hill (1960)] and to have some elementary knowledge of probability [e.g., Feller (1960), Papoulis (1965)]. No other familiarity with the molecular theory of liquids is presumed. For the convenience of the reader, we present in Chapter 1 the rudi ments of statistical mechanics that are required as prerequisites to an under standing of subsequent chapters. This chapter contains a brief and concise survey of topics which may be adopted by the reader as the fundamental "rules of the game," and from here on, the development is very slow and detailed.

There are essentially two theories of solutions that can be considered exact: the McMillan–Mayer theory and Fluctuation Solution Theory (FST). The first is mostly limited to solutes at low concentrations, while FST has no such issue. It is an exact theory that can be applied to any stable solution regardless of the number of components and their concentrations, and the types of molecules and their sizes. Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics outlines the general concepts and theoretical basis of FST and provides a range of applications described by experts in chemistry, chemical engineering, and biophysics. The book, which begins with a historical perspective and an introductory chapter, includes a basic derivation for more casual readers. It is then devoted to providing new and very recent applications of FST. The first application chapters focus on simple model, binary, and ternary systems, using FST to explain their thermodynamic properties and the concept of preferential solvation. Later chapters illustrate the use of FST to develop more accurate potential functions for simulation, describe new approaches to elucidate microheterogeneities in solutions, and present an overview of solvation in new and model systems, including those under critical conditions. Expert contributors also discuss the use of FST to model solute solubility in a variety of systems. The final chapters present a series of biological applications that illustrate the use of FST to study cosolvent effects on proteins and their implications for protein folding. With the application of FST to study biological systems now well established, and given the continuing developments in computer hardware and software increasing the range of potential applications, FST provides a rigorous and useful approach for understanding a wide array of solution properties. This book outlines those approaches, and their advantages, across a range of disciplines, elucidating this robust, practical theory.

Conformation and Hydration of Sugars and Related Compounds in Dilute Aqueous Solution.- Studies of Hydrophobic Bonding in Aqueous Alcohols: Enthalpy Measurements and Model Calculations.- Structure in Aqueous Solutions of Nonpolar Solutes from the Standpoint of Scaled-Particle Theory.- Raman Spectra from Partially Deuterated Water and Ice VI to 10.1 kbar at 28°C.- Solvation Equilibria in Very Concentrated Electrolyte Solutions.- Ionic Association in Hydrogen-Bonding Solvents.- The Role of Solvent Structure in Ligand Substitution and Solvent Exchange at Some Divalent Transition-Metal Cations.- N.