Molecularly Imprinted Polymers As Advanced Drug Delivery Systems

This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Molecularly imprinted polymers (MIPs) are an important functional material because of their potential implications in diverse research fields. The materials have been developed for a range of uses including separation, environmental, biomedical and sensor applications. In this book, the chapters are clustered into two main sections: Strategies to be employed when using the affinity materials, and rational design of MIPs for advanced applications. In the first part, the book covers the recent advances in producing MIPs for sample design, preparation and characterizations. In the second part, the chapters demonstrate the importance and novelty of creation of recognition imprinted on the materials and surfaces for a range of microbial detection sensors in the biomedical, environmental and food safety fields as well as sensing human odor and virus monitoring systems. Part 1: Strategies of affinity materials Molecularly imprinted polymers MIP nanomaterials Micro- and nanotraps for solid phase extraction Carbonaceous affinity nanomaterials Fluorescent MIPs MIP-based fiber optic sensors Part 2: Rational design of MIP for advanced applications MIP-based biomedical and environmental sensors Affinity adsorbents for environmental biotechnology MIP in food safety MIP-based virus monitoring MIP-based drug delivery and controlled release Biorecognition imprints on the biosensor surfaces MIP-based sensing of volatile organic compounds in human body odour MIP-based microcantilever sensor system

Molecular Imprinted Polymer Composites: Synthesis, Characterisation and Applications covers the design of composite materials containing nanostructures and molecular imprinted polymers that has materialized the ever-sought out vision of homogeneous molecular imprinted polymers. The inherent high surface-to-volume ratio of nanostructures has served well in increasing the surface area of conventional bulk polymers. In recent decades, molecularly imprinted polymer nanocomposite materials have attracted much attention for their potential applications in the fields of separation science, sensing, drug delivery, waste water treatment and catalysis, hence this book provides a much needed update on progress. Includes information on molecular imprinted polymer composites and their potential for commercialization Discusses their synthesis, characterization and applications Analyzes the effect of incorporation of different nanostructures on the thermodynamic, kinetic and adsorption behavior of imprinted sorbents

Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications

Controlled radical polymerization techniques for molecular imprinting, by Mark E. Byrne From bulk polymers to nanoparticles, by Lei Ye Post-imprinting and in-cavity functionalization, by Toshifumi Takeuchi Characterization of MIPs (affinity, selectivity, site heterogeneity...), by Richard Ansell Theoretical aspects and computer modelling, by Ian Nicholls MIPs in aqueous environments, by Bin Lu MIPs for binding macromolecules, by Kenneth J. Shea Solid phase extraction, by Ecevit Yilmaz Sensors, by Sergey A. Piletsky MIPs for catalysis and synthesis, by Marina Resmini Wastewater treatment, by Bo Mattiasson MIPs as tools for bioassays, biotransformation and drug delivery, by Meiping Zhao

Molecularly imprinted polymers (MIPs) are an important functional material because of their potential implications in diverse research fields. The materials have been developed for a range of uses including separation, environmental, biomedical and sensor applications. In this book, the chapters are clustered into two main sections: Strategies to be employed when using the affinity materials, and rational design of MIPs for advanced applications. In the first part, the book covers the recent advances in producing MIPs for sample design, preparation and characterizations. In the second part, the chapters demonstrate the importance and novelty of creation of recognition imprinted on the materials and surfaces for a range of microbial detection sensors in the biomedical, environmental and food safety fields as well as sensing human odor and virus monitoring systems. Part 1: Strategies of affinity materials Molecularly imprinted polymers MIP nanomaterials Micro- and nanotraps for solid phase extraction Carbonaceous affinity nanomaterials Fluorescent MIPs MIP-based fiber optic sensors Part 2: Rational design of MIP for advanced applications MIP-based biomedical and environmental sensors Affinity adsorbents for environmental biotechnology MIP in food safety MIP-based virus monitoring MIP-based drug delivery and controlled release Biorecognition imprints on the biosensor surfaces MIP-based sensing of volatile organic compounds in human body odour MIP-based microcantilever sensor system

The book Ligand describes the diversity and versatility of ligands, covering structural features, donor-acceptor properties and secondary functions like molecular recognition. Moreover, this book also provides a comprehensive account on the applicability like catalysis, sensors, supramolecular assembly, photochemical property, bioinorganic chemistry, and so on. The advancement of fundamentals in ligand design and the control of physicochemical properties of coordination compounds has largely increased emphasis on understanding the structural and electronic features toward different perspectives in materials science. In this regard, this book has a special appeal to chemists, biologists and others. This book will be beneficial for the graduate students, teachers, researchers and other professionals who are interested to fortify and expand their knowledge in chemistry, biology, microbiology, biotechnology, materials science, environmental science and so on.