Molecules Of Death 2nd Edition

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters ? carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters — carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject./a

Calibrating phylogenies to time is central to addressing many questions in evolutionary biology and macroevolution. The fossil record once provided our only source for establishing a timeline for evolution. However, the incompleteness of the fossil record and the non-uniformity of fossil recovery rate make it challenging to obtain precise estimates of divergence times from fossil evidence alone. Molecular dating, which combines evidence from the geological and molecular records, enables us to generate a much more complete and precise timeline of events. The molecular clock can be time-calibrated using temporal evidence from fossils and used to estimate divergence times based on the assumption that the rate of sequence evolution will be approximately constant over time and among lineages. Methodological challenges to applying this concept in practice have been to relax the assumption of constant evolutionary rates and to model the uncertainty associated with paleontological and geological calibrations. To this end, available statistical methods have become increasingly complex in order to capture key features of empirical data. These are typically applied using Bayesian inference, which provides a powerful framework for incorporating multiple sources of uncertainty. Although overall more effort has been expended in developing models of molecular sequence evolution, critical advances have also included approaches to modeling taxonomic diversification and fossilization. In particular, recent advances in birth-death process models have allowed for continuous sampling along lineages, enabling more information from the fossil record to be incorporated into dating analyses in a statistically coherent way. In addition, available dating methods can now be applied to scenarios in which no molecular data may be available, allowing for novel insights into the evolution of entirely extinct clades. Other recent innovations enable us to date divergence times among taxa that have no fossil record, including the use of gene duplication events or biogeographic evidence. Furthermore, time-calibrated trees are necessary for obtaining phylogenetic estimates of taxonomic diversification and extinction rates, which can now be jointly inferred along with lineage divergence times. These approaches offer an exciting opportunity to understand the evolution of life in deep time, although key challenges remain, especially with regards to modeling the processes of genome evolution, taxonomic diversification and fossil recovery. In this Research Topic, we focus on recent advances in methodology, outstanding challenges, and the application of molecular and paleontological dating methods to empirical case studies across the Tree of Life.

The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies.The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.

Gastroesophageal cancer is among the most common malignant diseases worldwide and is associated with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Chemotherapeutic drugs have achieved great success in the treatment of esophageal cancer; however, they also bring cytotoxicity to other organs and often have serious side effects. With the development of molecular diagnostics and biomarker discovery, the application of precision medicine has emerged to improve clinical outcomes. New antineoplastic therapy development is a timely topic in light of the recent development of precision medicine. New biotherapies aim to inhibit or regulate different targets, which are thought to be functionally selective or overexpressed in some types of tumors. In particular, progress has been made to understand the molecular biology of gastrointestinal cancer, resulting in the discovery of various molecular targets, such as KRAS, PD-1, PD-L1, EGFR, HER2 and VEGF. Moreover, anticancer agents, such as pembrolizumab, olaparib, trastuzumab, bevacizumab, either as single agents or in combination with conventional chemotherapy, have become part of the standard of care for treatment of advanced gastroesophageal cancer. This Research Topic provides a platform for recent studies on novel molecular targets and treatments for gastroesophageal cancer. Both Original Research articles and Reviews are welcome. Subjects may include but are not limited to: 1) Oncogenes and tumor suppressors; 2) Drug sensitivity/resistance; 3) Tumor metastasis and tumor microenvironment; 4) Biomarker discovery and epigenetic regulation.

The publication of the extensive seven-volume work Comprehensive Molecular Insect Science provided a complete reference encompassing important developments and achievements in modern insect science. One of the most swiftly moving areas in entomological and comparative research is molecular biology, and this volume, Insect Molecular Biology and Biochemistry, is designed for those who desire a comprehensive yet concise work on important aspects of this topic. This volume contains ten fully revised or rewritten chapters from the original series as well as five completely new chapters on topics such as insect immunology, insect genomics, RNAi, and molecular biology of circadian rhythms and circadian behavior. The topics included are key to an understanding of insect development, with emphasis on the cuticle, digestive properties, and the transport of lipids; extensive and integrated chapters on cytochrome P450s; and the role of transposable elements in the developmental processes as well as programmed cell death. This volume will be of great value to senior investigators, graduate students, post-doctoral fellows and advanced undergraduate research students. It can also be used as a reference for graduate courses and seminars on the topic. Chapters will also be valuable to the applied biologist or entomologist, providing the requisite understanding necessary for probing the more applied research areas related to insect control. Topics specially selected by the editor-in-chief of the original major reference work Fully revised and new contributions bring together the latest research in the rapidly moving fields of insect molecular biology and insect biochemistry, including coverage of development, physiology, immunity and proteomics Full-color provides readers with clear, useful illustrations to highlight important research findings

Lippincott® Illustrated Reviews: Immunology, 3rd Edition, offers an engaging, vividly illustrated presentation and all of the popular learning features of the Lippincott® Illustrated Review series to reinforce essential immunology concepts and connect basic science to real-life clinical situations. Like other titles in this series, this dynamic resource follows an intuitive outline organization and boasts a wealth of vibrant illustrations and study aids that clarify complex information and ensure retention. Whether used as a review text for a short immunology course or paired with Lippincott® Illustrated Reviews: Microbiology for a combined microbiology/immunology course, this revised and updated edition familiarizes readers with the latest practices in immunology and emphasizes clinical application to deliver unparalleled preparation for exams and clinical practice.