Monoclonal Antibodies In Headache

Intended to promote a more appropriate and modern therapeutic approach to migraine management, this book is the first to deal with monoclonal antibodies in this context. Authored by the most respected migraine experts from around the globe and drawing on the lessons learned in both clinical trials and clinical practice, it reviews the current state of knowledge on this important therapeutic innovation, which has produced impressive data in randomized controlled trials, and the efficacy and safety of which have been confirmed in day-to-day real-world use. Given its scope, the book will appeal to a broad range of specialists, including pharmacologists, clinical pharmacologists, neurologists and internists, but also to residents and medical students.

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

'A fantastic and much needed resource for all those suffering. Dr Katy Munro's experience and knowledge through this book will help all those who read it' Dr Rupy Aujla, The Doctor's Kitchen 'Dr Katy Munro is the single best migraine expert our family have ever met [...] This book brings hope to every migraineur' Miranda Sawyer, Guardian & Observer Journalist ***** Despite being one of the most common and debilitating conditions in the world, migraine is still widely misunderstood, stigmatised and misdiagnosed. Migraine is much more than 'just a headache', it's a genetic, neurological brain disorder, and it's time patients got the healp they really need. Managing Your Migraine is the practical go-to guide for understanding and treating migraine. In the book, headache Specialist and GP Dr Katy Munro will give you expert advice on: · Understanding your migraine phases and triggers · The impact of food, exercise and sleep on migraine · Rescue plans for acute attacks · Migraine preventers · Migraine in children · Managing your mental health with migraine If you're a person with migraine, or know someone struggling, this book will provide helpful strategies for alleviating your symptoms and managing your migraine. Drawing on her medical expertise, her own personal experience with migraine and the stories of her patients, Dr Munro will empower you to get to know your own migraine and build an effective treatment plan that will help you live your life more fully. Part of the Penguin Life Experts series.

A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.

A practical approach to the recognition and management of all aspects of migraine Migraine, characterized by periodic bursts of severe debilitating headache, is increasingly recognized as being not only a disease in its own right, but as a disorder that co-occurs with other disorders. Comorbidity in Migraine presents a clinically-oriented, comprehensive treatment approach to migraine. The international collection of authors cover: Migraine and Psychiatric Disorders Migraine and Vascular disorders Migraine and Epilepsy Migraine and other Pain Disorders Migraine and Medication Overuse Case vignettes and management algorithms enhance the clinical utility of the book.Comorbidity in Migraine enhances your ability to treat your migraine patients effectively to improve their quality of life. Titles of Related Interest Pediatric Headaches in Clinical Practice Hershey, Powers, Winner, Kabbouche (eds); ISBN 978-0-470-51273-9 Handbook of Epilepsy Treatment, 3e Shorvon; ISBN 978-1-4051-9818-9 Neurology: A Queen Square Textbook Clarke, Howard, Rossor, Shorvon (eds); ISBN 978-1-4051-3443-9

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