Multiple Sclerosis Bench To Bedside

Multiple Sclerosis (MS) is one of the main causes of disability in young adult population. The estimated burden of the disease worldwide is about three million people. The pathogenic mechanism of MS involves both auto immune and degenerative processes. These two mechanisms are thought to determine a combination of events leading to several clinical pattern of disease onset and course. Multiple Sclerosis: Bench to Bedside provides the most up-to-date and concise reviews on the critical issues of multiple sclerosis from around the world. This book is written by leaders and experts in the field of multiple sclerosis research and is divided into easy to read sections. Section I focuses on basic science aspects of Multiple Sclerosis, including potential biomarkers, molecular biology, heat shock proteins, oxidative stress, genetic and epigenetics. Section II focuses on clinical and epidemiological aspects of Multiple Sclerosis, including remyelination therapy, neuroplasticity-based technologies and interventions. This is an important reference book and a must-read for Postgraduate Medical Scholars, Basic Science Researchers and Neurologists in Clinical Practice.

Research and advances in the treatment of Multiple Sclerosis (MS) is a story of growing success. Great progress has been made in identifying the molecular mechanisms that can be utilized to develop highly efficacious treatments for MS patients. Since the middle of the last century, when studies using an inflammatory autoimmune model of MS i.e. experimental autoimmune encephalitis (EAE) were initiated, research on MS has since led to an enormous growth of knowledge. The limitations arising from these animal models have been partially compensated by insights generated from histopathological, immunological, genetic, imaging and clinical studies of MS. The importance of T cells and, recently of B cells, in MS has been elucidated and the significance of CNS resident cells, particularly in the progressive course of MS has been highlighted. The importance of environmental factors and genetic predisposition have also been recognized and the interaction between th e individual and its environment seems to play key roles in the pathogenesis of this disease. However, definite causative agent(s) or single gene(s) involved in MS still remain unidentified. A deeper understanding of the immunological pathways involved goes hand in hand with further improving therapy for MS. Focal inflammation in MS, caused by de novo CNS infiltration, can be prevented effectively using peripherally-acting drugs. However, diffuse CNS intrinsic inflammation and neurodegeneration are not targeted by the current arsenal of therapeutics and patients with progressive disease courses remain difficult to treat. Generating insights into pathophysiological processes and the clinical translation of this knowledge have been a formula of success for treating inflammatory diseases. The future will show whether this will hold true for CNS-trapped inflammation and neurodegeneration and whether the ultimate goal - truly curing MS - will be possible.

This text provides a comprehensive overview of the clinical and basic science aspects of MS. It is designed to be of practical use to clinical neurologists, and addresses all of the major issues that may occur in the management of persons with MS.

Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Provides an introduction on multiple sclerosis as an autoimmune disease, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Shows the changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Recent rapid changes in the field of multiple sclerosis management have made the task of staying well-informed a challenge for neurologists, and even more so for other healthcare practitioners who are involved in symptom evaluation and treatment. Multiple Sclerosis for the Non-Neurologist is an up-to-date resource for physicians, residents, fellows, and others who care for patients with MS. It contains authoritative information on all aspects of this complex disease, including monitoring requirements for patients with MS, potential risks and adverse events of disease modifying or symptomatic therapies, and possible drug interactions and contraindications of medications.

Multiple Sclerosis (MS) is an inflammatory, often progressive, and potentially disabling disease of the central nervous system. Onset of disease is usually between the ages of 15 and 50, with the incidence nearly twice as high in women. While the cause of MS is still unknown, the predominant theory is that it is an autoimmune disease, triggered by an unknown environmental factor that results in both loss of central nervous system myelin and degeneration of axons and neurons. Although there have been a number of publications addressing different aspects of MS treatment in the neurological literature, there is a dearth of material on MS designed for internists and primary care physicians, who are often the first to see patients presenting with symptoms of MS. Therefore, this concise, clinically focused volume will serve as a valuable resource tailored to the specific needs of internists and primary care physicians. Part of the Oxford Neurology Library, this highly practical pocketbook covers current approaches and new developments in the diagnosis, treatment and management of MS, including both early and advanced stages of the disease. The book offers in-depth coverage of special populations, as well as the more unusual manifestations of MS, which are less familiar to the internal medicine audience. It will also address the role of imaging studies in the diagnosis, differential diagnosis and monitoring of the progression of MS. In addition to providing up-to-date information on pharmacological therapies for MS, the book also describes an array of non-pharmacological treatment options.

Multiple sclerosis (MS) - a disease of the central nervous system - is the most common disabling neurological condition affecting young adults today. In her authoritative and inspiring book, Cynthia Benz demystifies the illness, explains its symptoms and patterns and offers a wealth of practical advice on coping with MS on a day-to-day basis. Including information on: - How to cope with stress and remain optimistic - Available therapies - from traditional drugs and physiotherapy to alternative treatments including acupuncture, homeopathy and massage - What help is on offer and where it can be found Revised and updated for the 21st century this is the essential handbook for people with MS, parents and carers alike.