Multiscale Modeling In Biomechanics And Mechanobiology

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

This volume covers aspects of multiscale modeling of the mechanics and mechanobiology of soft biological tissues. The individual contributions focus on the constitutive modeling from the micro to the macro level in addition to computational modeling and simulation. It consists of peer-reviewed papers written by leading international authorities and will serve as a major state-of-the-art source of reference for the next few years. It includes both review articles and original articles. Previously published in the Journal of Elasticity, Volume 129, Issue 1-2, December 2017.

Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.

This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

MULTISCALE BIOMECHANICS Model biomechanical problems at multiple scales with this cutting-edge technology Multiscale modelling is the set of techniques used to solve physical problems which exist at multiple scales either in space or time. It has been shown to have significant applications in biomechanics, the study of biological systems and their structures, which exist at scales from the macroscopic to the microscopic and beyond, and which produce a myriad of overlapping problems. The next generation of biomechanical researchers therefore has need of the latest multiscale modelling techniques. Multiscale Biomechanics offers a comprehensive introduction to these techniques and their biomechanical applications. It includes both the theory of multiscale biomechanical modelling and its practice, incorporating some of the latest research and surveying a wide range of multiscale methods. The result is a thorough yet accessible resource for researchers looking to gain an edge in their biomechanical modelling. Multiscale Biomechanics readers will find: Practical biomechanical applications for a variety of multiscale methods Detailed discussion of soft and hard tissues, and more An introduction to analysis of advanced topics ranging from stenting, drug delivery systems, and artificial intelligence in biomechanics Multiscale Biomechanics is a useful reference for researchers and scientists in any of the life sciences with an interest in biomechanics, as well as for graduate students in mechanical, biomechanical, biomedical, civil, material, and aerospace engineering.

Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels. Presents concepts in a theoretical and thermodynamic framework for each length scale Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems