Mutant

“It will be a dangerous mission. I don’t expect that any of us will survive. But it’s a chance to save mankind, to save our world. Maybe the last chance.” By the end of the twenty-third century, Earth is a plague-ridden, war-ravaged cesspool dominated by megacorporations whose ruthless armies fight one another for power and for the very scarce resources there are left. Capitol fighters Mitch Hunter and Nathan Rooker are battling the opposing forces of the Bauhaus corporation when a cannon blast exposes and destroys an ancient stone seal in the ground. From the bowels of the Earth crawl hordes of necromutants with razorlike boneblades for arms, hideous humanoids that thrive and multiply by commandeering the bodies of dying soldiers. Mitch barely escapes– only to discover that both the rise of the mutants and the “Deliverer” who will save humanity have been prophesied. Unless Mitch and a group of warriors from each of the megacorporations succeed in reaching the hidden horrors and wiping out the mutant scourge, ouir world will literally become a hell on Earth. Now a major motion picture

This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors Encompasses the current state of affairs in clinical trials to address resistance

Stepping effortlessly from myth to cutting-edge science, "Mutants" gives a brilliant narrative account of man's genetic code and the captivating people whose bodies have revealed it.

The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.

This comprehensive book covers the underlying scientific principles, state-of-the-art technologies and methodologies of plant mutagenesis. It covers historical development and commonly used terminologies, chemical and physical mutagenesis, mutation induction, mutation breeding and mutations in functional genomics research. Suitable both as a manual for professionals and a resource for students in plant breeding and research, the book includes exemplary cases of practical applications and an appendix of recommended doses of gamma and fast neutron irradiation for almost 200 plant species. It is

ER doctor Richard Steele is recruited into an anti-bioengineering movement which gathers steam at an explosive genetics conference in Hawaii. Activists warn that breakthroughs to create disease-resistant crops using new DNA strains will wreak havoc on the environment. But no one suspects the controversy could lead to the deadliest weapon of mass destruction ever unleashed upon the world. (May) Copyright © Libri GmbH. All rights reserved.

The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...