Myocardial Preservation

Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.

This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.

THE LANDMARK GUIDE TO ADULT CARDIAC, CONGENITAL CARDIAC, AND GENERAL THORACIC SURGERY--COMPLETELY UPDATED AND REVISED IN FULL COLOR An essential guide for daily clinical practice and a thorough review for the cardiothoracic boards, Johns Hopkins Textbook of Cardiothoracic Surgery is filled with authoritative guidance on surgical techniques and pre- and postoperative strategies for managing cardiothoracic disease. The content of this trusted classic reflects the rapidly changing field of cardiothoracic surgery. In addition to the basic curriculum required for certification, you will find coverage of advanced concepts, controversial issues, and new technologies. Johns Hopkins Textbook of Cardiothoracic Surgery provides an in-depth look at the full-spectrum of disorders and their surgical and medical management options, including congenital, acquired, and neoplastic diseases. Supporting this detailed coverage is an easy-to-navigate design and step-by-step explanations of the most complex operations. THE SECOND EDITION IS HIGHLIGHTED BY: NEW board review Q&A Ten NEW chapters including: Surgical Therapies for Atrial Fibrillation, Management of Adults with Congenital Heart Disease, and Stem Cells for Cardiac Surgical Disease NEW full-color illustrations An increased number of decision-making flow charts that will prove valuable when preparing for cases and examinations Key Concepts that highlight epidemiology, pathophysiology, clinical features, diagnostic and treatment strategies, and outcomes for each topic NOTE: This book was previously known as the Johns Hopkins Manual of Cardiothoracic Surgery but the second edition has been renamed to better reflect its scope and comprehensive nature.

Over the past ?fty years, advanced techniques and strategies have arisen in the ?eld of myocardial protection. Meticulous trials, focusing on pulmonary protection during heart surgery requiring cardiopulmonary bypass (CPB), have been missing. This te- book is intended to serve as a useful tool to spread information on strategies for lung protection during heart surgery with CPB. Emphasis on pulmonary protection will be turned to lung perfusion as an adjunct for minimizing the deleterious effects of pulmonary ischemia-reperfusion injury in heart surgery. Many renowned authors have contributed by presenting their expe- ence on lung perfusion in basic research and clinical trials. Furthermore, they have enlightened the quality of this textbook with new ideas, concepts, and future perspectives. The scope of this textbook is of interest to different professionals, such as card- vascular surgeons, pulmonary surgeons, transplantation physicians, cardiothoracic anesthesiologists, intensive care physicians, cardiothoracic fellows, radiologists, basic sciences physicians, cardiologists, pulmonary medicine physicians, perfusi- ists, nurses, students, and researchers. This textbook has 7 sections, aimed at addressing general and speci?c aspects of pulmonary protection during heart surgery with CPB. The ?rst section on general concepts provides information about anatomic, physiologic, histologic, molecular, and radiologic considerations regarding the lungs. The second section focuses on ischemia-reperfusion injury and is composed of several interesting chapters, addressing the basic science aspects of pulmonary p- tection, as well as experimental and clinical experiences from different heart surgery centers worldwide.

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses. The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases. Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.

In this volume, basic scientists, cardiologists and cardiac surgeons discuss all that is known about preconditioning/adaptation and how this state-of-the-art technique compares with conventional techniques of myocardial preservation, unveiling its mechanism of protection and potential clinical application.

A complete clinically orientated guide to cardiopulmonary bypass and extracorporeal support for trainee medical and technical personnel in cardiac surgery.