Natural Killer Cells

Natural Killer Cells
Author: Michael T. Lotze,Angus W. Thomson
Publsiher: Academic Press
Total Pages: 660
Release: 2009-11-12
Genre: Medical
ISBN: 0080919294

Download Natural Killer Cells Book in PDF, Epub and Kindle

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells

Natural Killer Cells

Natural Killer Cells
Author: Eric Vivier,James Di Santo,Alessandro Moretta
Publsiher: Springer
Total Pages: 247
Release: 2016-02-15
Genre: Medical
ISBN: 9783319239163

Download Natural Killer Cells Book in PDF, Epub and Kindle

To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.

Natural Killer Cells

Natural Killer Cells
Author: Srinivas S. Somanchi
Publsiher: Humana Press
Total Pages: 365
Release: 2016-05-13
Genre: Medical
ISBN: 1493936824

Download Natural Killer Cells Book in PDF, Epub and Kindle

This volume contains collection of Natural Killer Cell methodologies relevant for both basic and translational research. These methodologies present new developments in the natural killer (NK) cell field, such as understanding the influence of NK cells metabolism on its function, identifying complexity of NK cell subsets through mass cytometry, and determining the emergence of memory NK cells in murine model of MCMV infection. Methods that study NK cell migration and cytotoxicity through endpoint analysis or live single cell imaging are also discussed. Chapters also describe methods pertaining to translational application of NK cells, such as ex vivo expansion of NK cells on K562 cell lines genetically modified to express either membrane bound IL-15 or membrane bound IL-21, large scale NK cell culture, current techniques for engineering NK cells to express chimeric antigen receptors or chemokine receptors using retroviral vectors, electroporation of mRNA, and the natural phenomenon of trogocytosis. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy applications.

Natural Killer Cells

Natural Killer Cells
Author: Jacques Zimmer
Publsiher: Springer Science & Business Media
Total Pages: 428
Release: 2010-01-12
Genre: Medical
ISBN: 9783642023095

Download Natural Killer Cells Book in PDF, Epub and Kindle

Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.

Natural Killer Cell Protocols

Natural Killer Cell Protocols
Author: Kerry S. Campbell,Marco Colonna
Publsiher: Springer Science & Business Media
Total Pages: 394
Release: 2008-02-03
Genre: Medical
ISBN: 9781592590445

Download Natural Killer Cell Protocols Book in PDF, Epub and Kindle

In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial migration, in vivo detection of cells migrating into tumors, immunofluorescence staining of intracellular cytokines, and in vitro NK cell development. Valuable techniques for specific applications include vaccinia virus protein expression, soluble KIR-Fc fusions for HLA class I binding assays, calcium mobilization in cell conjugates, and identification of heterodimeric receptor complexes using cDNA library expression cloning. No less important are accounts of such classic methods as hybrid resistance, ADCC, viral defense, target cell cytotoxicity assays, cloning and culturing, tumor immunotherapy, and generation of HLA class I transfected target cells. Natural Killer Cell Protocols: Cellular and Molecular Methods offers immunologists, cancer researchers, virologists, and cell biologists today's most comprehensive collection of both established and cutting-edge techniques, methods that will contribute significantly to advancing our understanding of this fascinating and critically important class of cells.

Natural Killer

Natural Killer
Author: Harriet Alida Lye
Publsiher: McClelland & Stewart
Total Pages: 304
Release: 2020-12-29
Genre: Biography & Autobiography
ISBN: 9780771049248

Download Natural Killer Book in PDF, Epub and Kindle

"I need people to know that I exist, that their experiment worked, that by some combination of luck and science, I'm alive." In this harrowing and intimate memoir, Harriet Alida Lye explores how, at just fifteen years old, she was diagnosed with a form of leukemia called Natural Killer, named "the rarest and worst malignancy." The average survival time of patients with this diagnosis is fifty-eight days. There are no known survivors. There were no known survivors. Fifteen years after Harriet's diagnosis, she became pregnant, despite having been told that her chemotherapy treatment would likely make conception impossible. To be a mother is to make a death, as death is bound up in life. She knew her body had the ability to create death. She never trusted, was told to not even imagine, that it also had the power, that magical banality, to create life. Weaving in source material from the year she spent in hospital, written by both of her parents and her teenage self, this personal reflection is told through a seamless blend of narrative, snapshots, journal entries, and blog updates posted for friends and family. With probing lyricism and searing honesty, Natural Killer explores what it's like to live with a life-threatening illness and survive it; what it means for a body to turn against itself, to self-destruct from within; and what it takes to regain trust in a body that has committed the ultimate betrayal.

Innate Lymphoid Cells

Innate Lymphoid Cells
Author: Shoba Amarnath
Publsiher: Humana
Total Pages: 0
Release: 2020-03-09
Genre: Medical
ISBN: 107160337X

Download Innate Lymphoid Cells Book in PDF, Epub and Kindle

This volume explores the latest techniques used to characterize murine and human Innate Lymphoid Cells (ILC) subsets. This book also aims to discuss useful phenotypical and functional assays that may be relevant for studying ILC function in mice and humans. Chapters cover topics such as methods to study microbiome and enteroid cultures; characterizing ILC precursors; and cellular engineering of ILCs for therapeutic use. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Innate Lymphoid Cells: Methods and Protocols is a valuable research tool for anyone interested in ILC biology, and those interested in fundamental immunology, cellular engineering, cell signaling, and clinician scientists.

Antibody Fc

Antibody Fc
Author: Margaret Ackerman,Falk Nimmerjahn
Publsiher: Academic Press
Total Pages: 358
Release: 2013-08-06
Genre: Medical
ISBN: 9780123948182

Download Antibody Fc Book in PDF, Epub and Kindle

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system