Natural Products In Medicinal Chemistry
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Natural Products in Medicinal Chemistry
Author | : Stephen Hanessian |
Publsiher | : John Wiley & Sons |
Total Pages | : 652 |
Release | : 2013-12-18 |
Genre | : Medical |
ISBN | : 9783527676552 |
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The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer
Medicinal Natural Products
Author | : Paul M. Dewick |
Publsiher | : John Wiley & Sons |
Total Pages | : 524 |
Release | : 2002-01-03 |
Genre | : Medical |
ISBN | : 0471496413 |
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This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
Natural Products in Medicinal Chemistry
Author | : Stephen Hanessian |
Publsiher | : John Wiley & Sons |
Total Pages | : 800 |
Release | : 2013-12-18 |
Genre | : Medical |
ISBN | : 9783527676569 |
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The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer
Natural Products Chemistry
Author | : Raymond Cooper,George Nicola |
Publsiher | : CRC Press |
Total Pages | : 210 |
Release | : 2014-07-29 |
Genre | : Medical |
ISBN | : 9781466567610 |
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Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and Structures presents a practical guide to sourcing, isolating, and discovering new compounds from nature many of which become pharmaceutical drugs. This book emphasizes the challenges and advantages of products acquired from nature, compared to those obtained from combinatorial chemistry. A basic introduction, the book describes the whole cycle from farm to final compound, backed up by case studies drawn from industry and research applications. It broadens the scope of applications and draws upon examples from various sources. Natural products chemistry, as taught today, draws its examples mainly from marine chemistry or plant chemistry; however, there is also a fascinating and rich world of fermented (microbial and algal) products leading to complex structures. Thus, the book draws upon examples from the microbial world and from insects too. Therefore, this is a source of bioactive metabolites, not traditionally available in academic settings, more the mainstay of the pharmaceutical industry. Providing a roadmap of the process of collecting a compound from nature, isolating the active ingredient, and determining the chemical structure, this book provides a unique approach to the world of natural products.
Natural Products Pharmacology and Phytochemicals for Health Care
Author | : Debarshi Kar Mahapatra,Cristóbal Noé Aguilar,A. K. Haghi |
Publsiher | : Apple Academic Press |
Total Pages | : 258 |
Release | : 2021 |
Genre | : Business & Economics |
ISBN | : 1003057934 |
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"Medicinal chemistry and pharmacology are closely associated fields, and the use of natural products for their medicinal properties is ever-growing. The study of drugs from natural products and their effects on the living body are explored in this volume. The book looks into the research, discovery and characterization of the chemicals that exhibit biological effects. Providing an informative compilation of research, valuable case studies, and review of existing literature in the area, the book focuses on the ethnobotanical uses of natural products and phytochemicals for health care, including applications for diabeties, ulcers, wound healing, managing chronic alcoholism, hemorrhoidal treatment, cancer mitigation, pain management, immunotherapy, and more. The book briefly describes bioinformatics, artificial intelligence, machine learning, innovations, and societal applications. Natural Products Pharmacology and Phytochemicals for Health Care: Methods and Principles in Medicinal Chemistry provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. This volume provides new coverage of some of the latest technologies and approaches in drug discovery"--
Medicinal Chemistry of Bioactive Natural Products
Author | : Xiao-Tian Liang,Wei-Shuo Fang |
Publsiher | : John Wiley & Sons |
Total Pages | : 482 |
Release | : 2006-03-17 |
Genre | : Science |
ISBN | : 9780471739333 |
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Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents. Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research. Enhanced by examples with updated research results, the discussion covers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and its analogs * The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer's disease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIV agents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and their structurally modified mimics
Bioactive Natural Products
Author | : Goutam Brahmachari |
Publsiher | : World Scientific |
Total Pages | : 695 |
Release | : 2012 |
Genre | : Science |
ISBN | : 9789814335379 |
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Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.
Pharmaceutical Medicinal and Natural Product Chemistry
Author | : P. S. Kalsi,Sangeeta Jagtap |
Publsiher | : Alpha Science International, Limited |
Total Pages | : 0 |
Release | : 2013 |
Genre | : Chemistry, Organic |
ISBN | : 1842655981 |
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The modern approach to teaching and practice of organic chemistry represents the integration of traditional principles with molecular biology. The new emphasis firmly demands the study of organic chemistry teaching from its application to biochemical aspects, drug development and pharmaceutical aspects. The proposed organizational approach of the book will build from the principles of organic chemistry for example study of functional groups metabolic reactions, functionalization reactions, applications of spectroscopy, reactions and reagents and chemistry of natural products to their integration into pharmaceutical and medicinal chemistry. The proposed book in likely to be modern, readable and an interesting blend of organic and pharmaceutical chemistry, and would be useful for graduate students of both organic and pharmaceutical chemistry. The book has four principal aims: * Explains the principles of organic chemistry using biologically important molecules * Studies the chemistry of Natural products laying emphasis on general methods of structure elucidation, structure, synthesis and biogenesis from different classes of compounds * Useful for students of pharmacy covering the organic chemistry component * To face and excel in interview/selection committee in the subject of organic and pharmaceutical chemistry