Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma
Author: Michael Fehlings,Brian Kwon,Alexander R. Vaccaro,F. Cumhur Oner
Publsiher: Academic Press
Total Pages: 646
Release: 2022-02-17
Genre: Medical
ISBN: 9780128198360

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Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

Spinal Cord Injury SCI Repair Strategies

Spinal Cord Injury  SCI  Repair Strategies
Author: Giuseppe Perale,Filippo Rossi
Publsiher: Woodhead Publishing
Total Pages: 346
Release: 2019-10-30
Genre: Medical
ISBN: 9780081028087

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Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Indwelling Neural Implants

Indwelling Neural Implants
Author: William M. Reichert
Publsiher: CRC Press
Total Pages: 296
Release: 2007-12-17
Genre: Science
ISBN: 1420009303

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Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.

Spinal Cord Injury

Spinal Cord Injury
Author: Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Spinal Cord Injury
Publsiher: National Academies Press
Total Pages: 360
Release: 2005-07-27
Genre: Medical
ISBN: 9780309165204

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An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex. Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine's panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.

AOSpine Masters Series Volume 7 Spinal Cord Injury and Regeneration

AOSpine Masters Series  Volume 7  Spinal Cord Injury and Regeneration
Author: Michael G. Fehlings,Norbert Weidner
Publsiher: Thieme
Total Pages: 291
Release: 2016-09-15
Genre: Medical
ISBN: 9781638531579

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World-renowned experts share the latest updates in translational research as well as surgical and nonsurgical strategies for treating spinal cord injury Spinal cord injury (SCI) is a devastating, clinically challenging injury, leading to varying degrees of neurological function impairment and paralysis. Underlying biological mechanisms either inhibit or promote new growth in the spinal cord. Researchers have been making important discoveries about how neurons and their axons grow in the central nervous system and why they fail to regenerate after SCI. Although progress has been steady, there remains an urgent need to address issues in acute management such as early decompression and the use of biologics, as well as potential solutions for regeneration. Written by renowned experts in the ever-evolving field of SCI research and clinical practice, the 7th volume in the AOSpine Masters series is a state-of-the-art compendium on the latest in SCI diagnosis, spine surgery interventions, and long-term management. Each chapter contains pearls from leading spine specialists gleaned from the research laboratory and years of hands-on experience treating SCI patients in the emergency setting and long term. Key Features: Pathobiology, assessment, and diagnostic considerations The use of biomarkers as predictors of functional recovery Surgical and nonsurgical interventions for traumatic SCI The role of neural stem cells and biologics in spinal cord repair Functional and epidural stimulation and brain-computer interfaces The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This essential textbook delivers invaluable insights to spine surgeons, spinal cord injury clinicians and researchers and trainees, from translational researchers to experienced researchers and clinicians experienced in the operative and non-operative management of spinal cord injury.

Recovery of Motor Function Following Spinal Cord Injury

Recovery of Motor Function Following Spinal Cord Injury
Author: Heidi Fuller,Monte Gates
Publsiher: BoD – Books on Demand
Total Pages: 332
Release: 2016-08-17
Genre: Medical
ISBN: 9789535124979

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Restoration of motor function following spinal cord injury is a complex and challenging task. By reviewing emerging cellular, pharmacological, rehabilitative, as well as surgical approaches, this book seeks to highlight promising therapeutic strategies for the repair and regeneration of motor circuitry. The multidisciplinary nature of these approaches illustrates various routes to bridging the gap between the bench and the bedside and to identify the challenges that must be overcome in order to bring about a viable therapeutic strategy for spinal cord injury patients.

Spinal Cord Trauma Regeneration Neural Repair and Functional Recovery

Spinal Cord Trauma  Regeneration  Neural Repair and Functional Recovery
Author: L. McKerracher,G. Doucet,S. Rossignol
Publsiher: Unknown
Total Pages: 470
Release: 2002
Genre: Electronic Book
ISBN: 0444801049

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Textbook of Neural Repair and Rehabilitation

Textbook of Neural Repair and Rehabilitation
Author: Michael Selzer,Stephanie Clarke,Leonardo Cohen,Gert Kwakkel,Robert Miller
Publsiher: Cambridge University Press
Total Pages: 693
Release: 2014-04-24
Genre: Medical
ISBN: 9781107011670

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Volume 1 of the Textbook of Neural Repair and Rehabilitation covers the basic sciences relevant to recovery of function following injury to the nervous system.