Neuro Gastroenterology

Covers the pathophysiology, diagnosis, and management of the full range of clinical disorders involving both the nervous system and the gastrointestinal system.

This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.

Clinical and Basic Neurogastroenterology and Motility is a state-of-the-art, lucidly written, generously illustrated, landmark publication that comprehensively addresses the underlying mechanisms and management of common adult and pediatric motility disorders. These problems affect 50% of the population and include conditions such as dysphagia, achalasia, gastroesophageal reflux disease, gastroparesis, irritable bowel syndrome (IBS), gas and bloating, SIBO, constipation and fecal incontinence. The book brings together international experts and clinician scientists, epitomizing their years of wisdom into a concise yet practical text that is delivered in two distinct sections, basic and clinical. It fulfills a large unmet need, and bridges a long-awaited knowledge gap among trainees, clinicians, scientists, nurses and technicians, earnestly engaged in this field. First of its kind text that covers both basic and clinical aspects, bridging the knowledge gap, and providing a bench to bedside approach for management of common disorders Discusses the latest concepts and basic principles of neurogastroenterology and motility, and how the gut and brain interact in the genesis of functional gastrointestinal and motility disorders Provides an illustrated and practical text on hot topics written by leading adult and pediatric gastroenterology experts across the globe Includes an accompanying more detailed web version of the text with free access to future podcasts

This volume provides a comprehensive and up-to-date theoretical review and practical guide on pediatric gastrointestinal motility and functional disorders. The latest edition includes extensively revised and new chapters to reflect the rapidly growing field of pediatric neurogastroenterology. New topics covered include neurobiology of pain in children, functional oropharyngoesophageal assessment, dysautonomia, and psychotropic drugs. The text also features instructive illustrations, photographs, and tables. Written by world-renown experts in the field, Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children, Second Edition is a valuable resource for pediatric gastroenterologists, adult gastroenterologists, pediatricians, and all professionals involved in the treatment and management of children with such disorders.

"Studying rare genetic and molecular diseases of gut motility provides an understanding of their underlying mechanisms and may provide insights on the mechanisms or management of more common illnesses. For example, constipation affects 1 in 5 people 65 years or older and 1 in 10 people younger than 65 years, and slow-transit constipation or colonic inertia is responsible for approximately 10% of referrals of patients with constipation to gastroenterologists and, among all patients with constipation, is the cause in probably 1%. Insights on the pathophysiology and mechanisms of constipation are provided by studying Hirschsprung disease, mitochondrial cytopathy, or multiple endocrine neoplasia type 2B. These diseases are used to illustrate the congenital diseases of the enteric neuromuscular apparatus"--

Neurogastroenterology is devoted to "study the interface of all aspects of the digestive system with the different branches of the nervous system". Over the past 15 years advances in this field has greatly improved our understanding in primary functional and motility disorders in children. Neurogastroenterology has also begun to revolutionize our vision of "organic" diseases like inflammatory bowel disease, obesity, diabetes as well as microbial-host interactions. Major advances have also been achieved during these years in the knowledge of mechanisms of development of the enteric nervous system at the molecular level allowing a better understanding of diseases related to developmental anomalies and opening perspectives to new treatments with stem cells. Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children is dedicated to report the most accurate and recent knowledge in the field. Written by the world-renown experts, the book covers the field by providing a comprehensive and up-to-date review and practical guide to pediatric gastrointestinal motility and functional disorders for pediatricians, pediatric gastroenterologists, adult gastroenterologists and all professionals involved in the treatment of children with such disorders.

This third edition brings together the latest in research and clinical practice of the expanding field of pediatric neurogastroenterology. In addition to a comprehensive review of the current state of the art, many chapters have been significant revised and updated, covering the latest discoveries of the delicate and detailed mechanisms of the neuroenteric system as well as relationships of the latter with microbiota and metabolites produced by resident intestinal bacteria. The book also covers rapidly-changing techniques to assess clinical problems, along with international diagnostic criteria and recommendations and guidelines for clinical management. The content is supported by ample figures, photographs and selected video segments. Remaining the gold standard text in this up-and-coming field, Pediatric Neurogastroenterology 3e is dedicated to reporting the most accurate and recent knowledge available. Written by international experts in the field, the book is a comprehensive and up-to-date theoretical review and practical guide to pediatric gastrointestinal motility and functional disorders to pediatricians, pediatric gastroenterologists and all professionals involved in the treatment of children with such disorders.