Neuroendocrine Tumors In Real Life

This book on neuroendocrine tumors (NETs) aims to present, in a clear and innovative manner, a broad topic that is still unevenly and in some respects poorly delineated. The novel feature is the nature of the focus on the principles of prognosis, diagnosis, and therapy, which are outlined on the basis of well-defined clinical scenarios described with the aid of high-quality images and illustrations. The salient observations to emerge from the reported clinical cases are clearly summarized, taking into account evidence from the literature and the available guidelines. All of the significant prognostic factors – histopathological, molecular, and imaging – and current diagnostic and therapeutic strategies for the major NETs (stomach, pancreas, ileum, appendix, bronchus) are covered. In addition, in the introductory part of the book the reader will find information on basic aspects including epidemiology, classification, and underlying biological mechanisms. Neuroendocrine Tumors in Real Life will be of interest to all specialists involved in the management of NETs; it will provide the experienced with important updates and equip trainees and students with a firm understanding of key concepts.

This book is a timely textbook that covers all aspects of neuroendocrine tumors (NET) from epidemiology, pathological classification and evaluation and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies. The various types of NET are individually discussed, including carcinoid tumors, insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, medullary thyroid carcinomas, adrenocortical cancer, pheochromocytomas, paragangliomas and non-functioning pancreatic NETs. The contributing authors are internationally recognized experts who bring a wealth of experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists and pathologists and also trainees.

This comprehensive subspecialty reference book on NeuroEndocrine Tumor (NET) pathology brings together the diagnostic and clinical expertise of an outstanding team of practicing neuroendocrine pathologists and oncologists. In addition to in-depth coverage of clinico-pathologic aspects of NETs of the various organ systems, the recent histological grading and staging schemes proposed by the North American and European NeuroEndocrine Tumor Societies (NANETS, ENETS), the World Health Organization (WHO) and the American Joint Committee on Cancer (AJCC), this book also focuses on the recent molecular and therapeutic advances in the field of NET pathology and oncology. Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances will be an essential reference book for anatomic pathology (histopathology) residents, fellows, surgical pathologists, researchers, oncologists, surgeons and other medical professionals practicing advanced NET Pathology and Oncology in academia, community, private practice and research settings.

The term ‘carcinoid’ entered medical literature over 100 years ago to describe a peculiar intestinal epithelial neoplasm. Since then, a large body of literature has expanded the concept of carcinoid, later replaced by the term ‘NeuroEndocrine Tumor’ (NET), defining a wide spectrum of peculiar tumors, potentially affecting all organs and tissues, originating from neuroendocrine cells, sharing, but, at the same time, keeping, pathognomonic pathological, radiological and clinical features. This book provides an authoritative overview of the epidemiological, clinical, genetic, molecular and pathological characteristics of NETs and highlights the most relevant controversial issues in the classification, diagnosis and therapy. Furthermore the new frontiers in the field of medical therapies are presented, through a multidisciplinary and translational approach. Considering the fact that NETs have been recently demonstrated less rare as considered so far, 'Neuroendocrine Tumors: A Multidisciplinary Approach' is a must read for endocrinologists, gastroenterologists, endocrine surgeons, as well as pathologists, nuclear medicine physicians and radiologists focused on NET.

This issue of Endocrinology and Metabolism Clinics, edited by Dr. Ashley Grossman, will focus on Innovations in the Management of Neuroendocrine Tumors. Topics include, but are not limited to, Molecular targeted therapy of NETs – State of the art; Surgical approaches to the management of liver metastases; Liquid biopsies for NETs – circulating tumour cells and DNA; Novel functional imaging of NETs; The problem of appendiceal carcinoids; Peptide radioreceptor therapy comes of age; Current chemotherapy use in NETs; The problem of grade 3 NETs; Molecular genetic studies of pancreatic neuroendocrine tumours reveal new therapeutic approaches; The new WHO classification; Gastrinomas – medical or surgical treatment; When and how to use somatostatin analogues; The NETest as the way forward; Lung and thymic carcinoids; Carcinoid heart disease; Gastric carcinoids; New treatments for the carcinoid syndrome; and The genesis of the NETs concept – From Oberdorfer to 2018.

Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions. The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.

This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.