Neurogenic Inflammation In Health And Disease

Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain. Neurogenic inflammation in historical perspective Cardiac protection by nociceptive afferents Molecular mechanisms of nociception Sensory mechanisms in migraine pathophysiology Vagal signaling of visceral inflammation Neurogenic mechanisms in arthritis Therapeutic implications of vanilloid-type compounds

Take advantage of this unique book - the first single-volume resource to explore all important aspects of neurogenic inflammation. An unrivaled compilation of up-to-date information, Neurogenic Inflammation contains chapters written by recognized authorities in their areas of expertise. It covers the basic mechanisms and the pathophysiological implications of neurogenic inflammatory processes and points to novel therapeutic strategies in the field of inflammatory and related diseases. The book highlights the many systems and mechanisms involved in neurogenic inflammation, including vasodilatation, plasma extravasation, leukocyte adhesion, smooth muscle contraction, exocrine gland secretion, and recruitment of inflammatory cells. The authors discuss the contribution of neurogenic inflammation to human diseases, such as migraine, asthma, arthritis, and inflammatory bowel disease, linked to the ubiquitous distribution of sensory nerves to organs and tissues at both the somatic and visceral level. Neurogenic Inflammation is the clear choice for a one-step, authoritative guide to the latest developments in this dynamic field.

Offers coverage of practical and theoretical implications of current research into mast cell biology, emphasizing the role of the mast cell in human diseases. The text covers all aspects of the mast cell from growth and differentiation to its function in such conditions as asthma and skin disease.

Frontiers in Clinical Drug Research - Anti-Allergy Agents is an exciting eBook series comprising a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs. The second volume of this series brings 7 reviews which cover neuro- and immunomodulating therapies for asthma and COPD, antioxidant therapies for allergies, allergic rhinitis medications and more. Frontiers in Clinical Drug Research - Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms. Provides information on the importance and applicability of the field of neuroimmunology Describes subjects that have shown significant recent developments Introduces a whole new dimension to neuroimmunology by discussing Epigenetic Immunoregulation Investigates the mechanisms and functions of the Neuroimmune Regulatory Supersystem Promotes translational research in the field of neuroimmune biology Covers challenges, such as dealing with problems of e.g., hypothalamic regulation of immune functions, interrelationships of stress and disease, epigenetic immunoregulation, neuroprotection, and neuroimmune regulation in pregnancy.

The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation