Neurovirology

The plethora of miscommunication and disinformation about how SARS-CoV-2 (COVID-19) spreads suggests a widespread misunderstanding of how viruses work. This book will focus on the interpretation of scientific and medical results, giving the reader guidance on interpreting virological data, including the concepts of 'live' versus infectious virus. The first section covers the background of virology and immunology, introducing the reader to the science of virology (using COVID-19 as an illustration) and considers the measurement of infectious disease, using polymerase chain reaction (PCR), molecular biology and the immune system. The second section looks at clinical virology and neurovirology. Taking a novel perspective on how viruses may play a role in evolution, this book discusses antivirals and how autoimmune disorders may be caused or triggered by viruses. Concise and practical, this is a key resource for those working in neurology, infectious disease and virology.

This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology. Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere. Detailed coverage of neurovirology from the basic science to clinical presentation Covers advances in neurovirology via polymerase chain reaction (PCR) and MRI technology Covers emerging and re-emerging diseases including HIV/AIDS, Nipah encephalitis, and the appearance of West Nile encephalitis in the western hemisphere

This volume is the first in a planned series of thematic volumes for Advances in Virus Research. It covers the etiology, pathogenetic mechanisms, and clincial consequences of human neurotropic viruses. Buchmeier is a virologist, Campbell an immunologist, and both are extremely well known in their fields. Numerous illustrations including colour Knowledgeable discussion of the potential role of viral infections in teratogenic and developmental disorders Frank discussion of the role of stress in disease Behavioural consequences of chronic CNS infection

The plethora of miscommunication and disinformation about how SARS-CoV-2 (COVID-19) spreads suggests a widespread misunderstanding of how viruses work. This book will focus on the interpretation of scientific and medical results, giving the reader guidance on interpreting virological data, including the concepts of 'live' versus infectious virus. The first section covers the background of virology and immunology, introducing the reader to the science of virology (using COVID-19 as an illustration) and considers the measurement of infectious disease, using polymerase chain reaction (PCR), molecular biology and the immune system. The second section looks at clinical virology and neurovirology. Taking a novel perspective on how viruses may play a role in evolution, this book discusses antivirals and how autoimmune disorders may be caused or triggered by viruses. Concise and practical, this is a key resource for those working in neurology, infectious disease and virology.

This is a comprehensive reference that includes the basic science, clinical features, imaging, pathology and treatment of specific viral entities affecting the central nervous system (CNS). It will assist professionals in their attempt to identify, examine and manage viral CNS infections and unravel the therapeutic and diagnostic challenges associated with viral CNS disorders. Key Features Features MRI scans, histopathology and lined diagrams showing pathophysiology Much has happened in our understanding of CNS infections in recent years and a comprehensive book that covers the entire subject is much needed. There is ongoing interest in infectious disease. The increasing globalization of medicine is putting demands on many more people to become familiar with issues from around that world that they did not see in training.

Neurovirology, the study of viral infection of the ner vous system, has evolved at the interface of three of the most rapidly unfolding fields of investigation-neurobiology, vi rology, and immunology. In all three, increasing knowledge about the molecular structure of surface receptors, how in tracellular messages are transmitted, and how diversity is regulated genetically is provided, along with the techniques of molecular biology. This promises to give us knowledge not only about the process of infection and the complex host and viral determinants of neuroinvasiveness and neurovirulence, but eventually it will provide the background from which to engineer vaccines and to devise novel therapeutic agents. Animal virology and molecular biology developed quite independently from different origins. Animal virology was originally the province of the pathologists, and by clinical observation and histological preparations, they tried to ex plain the incubation period, the pathways of virus spread, and the mechanisms of disease. Molecular virology grew out of biochemistry, particularly through studies of bacterio phage, with emphasis on the physical and chemical structure of viruses and the sequences of biochemical events during the replicative cycle in cells.

This comprehensive and up-to-date reference reviews the fundamental ideas and terminology used to evaluate viral and immune-mediated diseases and details the taxonomy, pathogenesis, epidemiology, immunology, clinical and differential diagnosis, and treatment of viral and virus-induced immune-mediated diseases of the nervous system. Uniting the clinical aspects and the basic biology of virus infections of the nervous system, the Handbook of Neurovirology examines all aspects of the immune response to virus infection, including cellular and humoral immunity as well as interferon and cytokine responses investigates the new concept of molecular mimicry analyzes cerebrospinal fluid abnormalities associated with viral and immune-mediated syndromes describes both RNA and DNA viruses and their diseases covers virus classification, virion structure and structural proteins, viral genome structure, and viral gene regulation and replication discusses selected animal models of viral infections that have been especially useful in delineating the pathogenesis of viral infections in man and more!

Neurovirology, the study of viral infection of the ner vous system, has evolved at the interface of three of the most rapidly unfolding fields of investigation-neurobiology, vi rology, and immunology. In all three, increasing knowledge about the molecular structure of surface receptors, how in tracellular messages are transmitted, and how diversity is regulated genetically is provided, along with the techniques of molecular biology. This promises to give us knowledge not only about the process of infection and the complex host and viral determinants of neuroinvasiveness and neurovirulence, but eventually it will provide the background from which to engineer vaccines and to devise novel therapeutic agents. Animal virology and molecular biology developed quite independently from different origins. Animal virology was originally the province of the pathologists, and by clinical observation and histological preparations, they tried to ex plain the incubation period, the pathways of virus spread, and the mechanisms of disease. Molecular virology grew out of biochemistry, particularly through studies of bacterio phage, with emphasis on the physical and chemical structure of viruses and the sequences of biochemical events during the replicative cycle in cells.