New Directions For Chemoprevention Research At The National Cancer Institute

This volume offers a broad overview of topics related to cancer chemoprevention. It provides a review of topics ranging from basic research arenas to clinical trial design, implementation, and interpretation. It covers all key areas necessary for understanding the field of cancer chemoprevention for the interested reader, for individuals wishing to enter this area of investigation, and for individuals seeking guidance in particular areas of research, relating to agent identification, basic science investigations and clinical trials. The genesis of this book is based on the fact that cancer chemoprevention is a relatively new and rapidly evolving field spanning a wide array of disciplines, and forces researchers to address difficult and complex questions whose answers are not readily available. Cancer Chemoprevention provides a ready resource whose importance and intent lie in its ability to gather and solidify disparate data to explicitly outline areas of difficulty and to highlight future areas of important development. It provides broad outlines for current, ongoing and future directions in this area with various target organ sites, written by experts in their respective fields, whose primary research focuses upon that individual field.

The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.

Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.

Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.