Notes On The Heart

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.

#1 NEW YORK TIMES BESTSELLER • In her latest book, Brené Brown writes, “If we want to find the way back to ourselves and one another, we need language and the grounded confidence to both tell our stories and be stewards of the stories that we hear. This is the framework for meaningful connection.” Don’t miss the five-part HBO Max docuseries Brené Brown: Atlas of the Heart! In Atlas of the Heart, Brown takes us on a journey through eighty-seven of the emotions and experiences that define what it means to be human. As she maps the necessary skills and an actionable framework for meaningful connection, she gives us the language and tools to access a universe of new choices and second chances—a universe where we can share and steward the stories of our bravest and most heartbreaking moments with one another in a way that builds connection. Over the past two decades, Brown’s extensive research into the experiences that make us who we are has shaped the cultural conversation and helped define what it means to be courageous with our lives. Atlas of the Heart draws on this research, as well as on Brown’s singular skills as a storyteller, to show us how accurately naming an experience doesn’t give the experience more power—it gives us the power of understanding, meaning, and choice. Brown shares, “I want this book to be an atlas for all of us, because I believe that, with an adventurous heart and the right maps, we can travel anywhere and never fear losing ourselves.”

Heart of Darkness is often considered the world’s best short novel. The book serves as a bridge between the 19th century and modernism, an adventure tale revolving around the ambiguity of themes such as truth, morality, and evil. Joseph Conrad witnessed the European exploitation of the Congo with his own eyes. He once sailed up the Congo River himself to locate a countryman at a trading station deep within the country – even though this man wasn't named Kurtz. The goal and enigma of the journey have become synonymous with this name, one of the most unforgettable fictional characters of our time. JOSEPH CONRAD [1857–1924] was born in Ukraine to Polish parents, went to sea at the age of seventeen, and ended his career as a captain in the English merchant navy. His most famous work is the novella Heart of Darkness [1899], adapted into a film by Francis Ford Coppola in 1979 as Apocalypse Now.

A complete guide to the tools and techniques for modeling, simulating, and optimizing SSFE processes and phenomena In Modeling, Simulation, and Optimization of Supercritical and Subcritical Fluid Extraction Processes, a team of expert chemical engineers delivers a comprehensive guide to the tools and techniques used to model supercritical and subcritical fluid extraction (SSFE) processes and phenomena. The book offers details on SSFE experiment management, as well as modeling and optimization of SSFE. The authors begin with a discussion of the fundamentals of SSFE and the necessary experimental techniques to validate the models. They also discuss process simulators, conventional optimization techniques, and state-of-the-art genetic algorithm methods. Several practical examples and case studies on SSFE modeling and optimization techniques are provided. Additionally, detailed thermodynamic modeling with and without co-solvent and non-equilibrium system modeling are covered. Readers will also find: A detailed overview of the field of supercritical and subcritical fluid extraction and their importance to the food, cosmetics, and pharmaceutical industries Explorations of the concepts and methodologies for modeling, simulation, and optimization of SSFE, including conservation laws related to SSFE traditional first principle modeling Practical discussions of the characteristics and physical properties of palm oil as a solute and descriptions of some existing palm oil industrial processes An examination of first principle methodology as applied to the modeling of the properties of palm oil components and mixtures Perfect for researchers, scientists, technologists, and engineers working in food science and the pharmaceutical, cosmetic, and agricultural industries, Modeling, Simulation, and Optimization of Supercritical and Subcritical Fluid Extraction Processes is also a must-read for those working with process design, development, quality control, and improvement in the chemical industries.

Do you dread writing notes to say "Thank you," "I'm sorry," or "Congratulations"? When's the last time you sent a handwritten letter to a faraway friend, just to catch up? What should you write to a grieving friend or colleague? How do you let friends know you're getting a divorce? As our lives get busier and faster-paced, the old-fashioned art of personal correspondence is becoming sadly lost. In this upbeat, wise, and witty guide, journalist and lifestyle expert Sandra Lamb offers a wealth of advice, inspiration, and examples for anyone who wants to add flair, voice, and plain old fun to their letters and notes---as well as anyone who wants to know the etiquette of when and what to write. Using colorful examples and practical advice, the book covers thank yous, congratulations, engagements and weddings, birthdays and anniversaries, births and adoptions, appreciation, love notes, illness and accidents, divorce, condolence, regrets, apologies, and forgiveness. This delightful, indispensable guide helps us rediscover the joy of connecting with others through the simple act of putting pen to paper.