Ntp Technical Report On The Toxicology And Carcinogenesis Studies Of 2 Butoxyethanol Cas No 111 76 2 In F344 N Rats And B6c3f1 Mice Inhalation Studies

Methylene Blue Trihydrate (MBT) has a variety of biomedical and biologically therapeutic applications. MBT was nominated by the Nat. Cancer Inst. for carcinogenecity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of MBT, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered MBT in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using ¿Salmonella typhimurium,¿ ¿Escherichia coli,¿ cultured Chinese hamster ovary cells, mouse bone marrow cells, and mouse peripheral blood erythrocytes. Illustrations.

a-Methylstyrene is used to make heat-resistant acrylonitrile-butadiene-styrene resins & polymers. This report studies the effects of a-methylstyrene on male & female rats & mice to identify potential toxic or cancer-related hazards. It concludes that exposure to a-methylstyrene in the air caused kidney tumors, & possibly mononuclear cell leukemia, in male rats. It concludes that a-methylstyrene caused liver cancer in female mice, & also possibly in male mice. Charts, tables, graphs & plates.