Optimizing Ace King

Ace King is a massively profitable hand. In fact, AK is in the top-5% of winning hands and accounts for a good chunk of your winrate. But despite that fact, many players are confused about how to approach this hand. Should you 3bet it preflop, or just call it? Should you play the suited and offsuit versions the same, or differently? Should you c-bet with air, or check instead? And how many streets of value is top pair really worth?Most players struggle with AK due to small leaks in their strategy. So Optimizing Ace King (OAK) doesn't look to give you a bunch of memorized plays and tactics. Instead, OAK shows you how AK fits within your strategy and ranges. This prepares you for playing AK, among other hands, in a variety of spots and under a variety of conditions.James "SplitSuit" Sweeney and Adam "W34Z3L" Jones co-wrote this book to take an in-depth look at poker strategy through the lens of a single hand. Concepts include 3betting, 4betting, cbetting, barreling, GTO vs. exploitative play, and deducing lines from GTO solver output. You will play AK 99.9% of the time you are dealt it, and since it makes up such a large chunk of your winrate, doesn't it make sense to strengthen your approach with it? Each chapter builds upon the last, walking you through preflop play, flop play (when you hit, miss, and flop draws), and turn + river play. Plus there is an entire chapter full of examples and a chapter dedicated strictly to tournaments. If your winrate with AK could use a boost, invest a few chips and see the ROI in no time at all!(The foreword is written by legendary poker author Ed Miller)

The first volume in a series, the book reviews a collection of poker hands played from the button, cutoff, and hijack positions which illustrate concepts to help improve the reader's poker game.

This poker workbook has one goal: to help you actually improve between sessions. By learning powerful concepts and drilling through exercises, your ability to calculate accurately and quickly at the tables improves. Your time at the tables shouldn't be spent trying to calculate pot odds of a call or the breakeven-% of your bluffs. Calculations like these should be automatic, giving you extra time and brainpower to find ways to optimize your edge during a hand. Now you can practice the math that underlies all aspects of your poker strategy. Drill through the technical side of your preflop playbook. And start putting a bigger gap between your winrate and the regs in your game. This workbook teaches you the formulas and lays out practice exercises for concepts like: Equity Range Building/Hand Reading Combos & Blockers Pot Odds Implied Odds Breakeven % & Auto-Profit Expected Value (EV) Open-Raising 3Betting & 4Betting Preflop All-Ins By learning these simple formulas and practicing them at your own pace, you'll find poker math getting far easier. You don't need an IQ of 175 to master poker math - you just need some guidance, some shortcuts, and some in-depth training. Complete just a few pages per day, and you'll see serious improvement in the next month. And the best news is that these concepts come into play in every single session, at every single level, and wherever you happen to play poker. So the examples in this book range from live cash games to online tournaments - without bogging you down with confusing variables that will never apply to the poker games you play. The Answer Key Based upon feedback from previous workbooks, there is an included answer key so you can double-check your answers at any point. There is a link on Page #246 so you can download the answer key OR use the online version that will get lifetime updates. This key also includes all of the range strands, making it easy to copy ranges from the workbook and paste them directly into your poker software. Is This Workbook For You? We all have to start somewhere, and no one is born with technical poker knowledge imprinted in their brain. So truthfully answer each of these: Can you look at a range and correctly estimate its %-form and number of combos? If not, then this book is for you. Do you know how often a player would fold if you 3bet or squeezed them? If not, this book is for you. Do you know how many combos of AQ a player can have on AQ4 when you hold AKs? If not, this book is for you. Do you know how much extra money you need to make when you have 15% equity and are getting 3:1 on a turn call? If not, then this book is for you. Do you know how often you can expect both the blinds to fold when you raise from the button? If not, this book is for you. Do you know how much equity AKs has against a range of QQ+/AK? If not, this book is for you. Are you 100% confident in your poker math skills yet? If not, then this book is for you. No more excuses. No more confusion when it comes to the core poker math. And no more reasons for skipping another study session. Pick up the Preflop & Math Poker Workbook and start seeing your strategy the right way. Good luck! The spiral design on the cover/back is purely decoration. Unfortunately, spiralbound printing is not an available option at this time.

Why do some poker players become immensely successful while others fall by the wayside?What is it that separates the successes from the failures?Is there a magic formula? Over the last 12 years, Lance Bradley has been one of poker’s leading journalists and now finds himself at the helm of PocketFives.com as President and Editor-in-Chief. During his time covering the poker world, Bradley has interviewed hundreds, if not thousands, of the world’s best players. This experience has revealed one fascinating trend; contrary to what might be expected, there is no single guaranteed path to success. Each and every poker player featured in The Pursuit of Poker Success has taken their own route to becoming one of the world’s best players. The players interviewed for this book include World Series of Poker bracelet winners, World Poker Tour champions, online poker wizards and some of the best cash game players on the planet. Bradley spoke to each player about the way in which they found success in a game that can be humbling for so many. What worked for them can work for you.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Modern Poker Theory is a comprehensive, rigorous guide to the most important aspects of No-Limit Hold’em. It is based around an in-depth examination of what is meant by game theory optimal play (GTO) and how it can be applied at the table. Understanding GTO is fundamental to being able to make accurate poker decisions and being able to exploit players who don’t. Modern Poker Theory uses modern poker tools to develop a systematic approach to the analysis of GTO. It organizes the ideas and concepts in an intuitive manner that is totally focused to practical applications. Next time you are at a table some of the players will have studied Modern Poker Theory and some won’t. The players who have studied Modern Poker Theory will, without doubt, have a better theoretical and practical understanding of No-Limit Hold’em. They will be the favourites in the game. Make sure you are one of them. Michael Acevedo, one of the world’s leading poker theorists, is a game theory expert who is renowned for creating cutting-edge content for the world’s leading players. The production of Modern Poker Theory is the culmination of many thousands of hours of his research work with the most advanced poker software tools available. It is poker theory for the 21st century.

The significantly expanded and updated new edition of a widely used text on reinforcement learning, one of the most active research areas in artificial intelligence. Reinforcement learning, one of the most active research areas in artificial intelligence, is a computational approach to learning whereby an agent tries to maximize the total amount of reward it receives while interacting with a complex, uncertain environment. In Reinforcement Learning, Richard Sutton and Andrew Barto provide a clear and simple account of the field's key ideas and algorithms. This second edition has been significantly expanded and updated, presenting new topics and updating coverage of other topics. Like the first edition, this second edition focuses on core online learning algorithms, with the more mathematical material set off in shaded boxes. Part I covers as much of reinforcement learning as possible without going beyond the tabular case for which exact solutions can be found. Many algorithms presented in this part are new to the second edition, including UCB, Expected Sarsa, and Double Learning. Part II extends these ideas to function approximation, with new sections on such topics as artificial neural networks and the Fourier basis, and offers expanded treatment of off-policy learning and policy-gradient methods. Part III has new chapters on reinforcement learning's relationships to psychology and neuroscience, as well as an updated case-studies chapter including AlphaGo and AlphaGo Zero, Atari game playing, and IBM Watson's wagering strategy. The final chapter discusses the future societal impacts of reinforcement learning.